Results 21 to 30 of about 20,405 (323)

Silk/Natural Rubber (NR) and 3,4-Dihydroxyphenylalanine (DOPA)-Modified Silk/NR Composites: Synthesis, Secondary Structure, and Mechanical Properties

Molecules, 2020
Silk composites with natural rubber (NR) were prepared by mixing degummed silk and NR latex solutions. A significant enhancement of the mechanical properties was confirmed for silk/NR composites compared to a NR-only product, indicating that silk can be ...
Hiromitsu Sogawa, Treratanakulwongs Korawit, Hiroyasu Masunaga, Keiji Numata   +3 more
doaj   +1 more source

Impairment of Serotonergic Transmission by the Antiparkinsonian Drug L-DOPA: Mechanisms and Clinical Implications [PDF]

, 2017
The link between the anti-Parkinsonian drug L-3,4-dihydroxyphenylalanine (L-DOPA) and the serotonergic (5-HT) system has been long established and has received increased attention during the last decade.
Benazzouz, Abdelhamid, De Deurwaerdère, Philippe, Miguélez Palomo, Cristina, Ugedo Urruela, Luisa   +3 more
core   +2 more sources

Effect of Selective Serotonin Reuptake Inhibitors via 5-HT1A Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model

Journal of Pharmacological Sciences, 2012
l-Dihydroxyphenylalanine (l-DOPA) is considered the gold standard for the treatment of Parkinson’s disease (PD). However, long-term administration of l-DOPA can induce abnormal side effects.
Masatoshi Inden, Mari Abe, Hideaki Minamino, Kazuyuki Takata, Kanji Yoshimoto, Ikuo Tooyama, Yoshihisa Kitamura   +6 more
doaj   +1 more source

Synthesis of the Isodityrosine Moiety of Seongsanamide A–D and Its Derivatives

Marine Drugs, 2023
The concise and highly convergent synthesis of the isodityrosine unit of seongsanamide A–D and its derivatives bearing a diaryl ether moiety is described.
Yang Xie, Zhou Xu, Pei Hu, Xiao-Ting Tian, Yi-Hong Lu, Hao-Dong Jiang, Cheng-Gang Huang, Zhi-Cai Shang   +7 more
doaj   +1 more source

Cholinergic modulation of dopamine overflow in the rat neostriatum: A fast cyclic voltammetric study in vitro [PDF]

, 1994
Stimulus-evoked dopamine overflow in rat neostriatal slices was determined using fast cyclic voltammetry. The dopamine efflux induced by intrastriatal stimulation increased with stimulus intensity and was found to be enhanced by more than 100% upon ...
Kudernatsch, Martina, Sutor, Bernd
core   +1 more source

The Use of the Calcitonin Minimal Recognition Module for the Design of DOPA-Containing Fibrillar Assemblies

Nanomaterials, 2014
Amyloid deposits are insoluble fibrous protein aggregates, identified in numerous diseases, which self-assemble through molecular recognition. This process is facilitated by short amino acid sequences, identified as minimal modules.
Galit Fichman, Tom Guterman, Lihi Adler-Abramovich, Ehud Gazit   +3 more
doaj   +1 more source

Principles of personalized medicine and modern pharmaceutical technologies to optimize levodopa therapy of Parkinson's disease

Анналы клинической и экспериментальной неврологии, 2021
Levodopa (3-hydroxy-L-tyrosine, the levorotatory isomerof 3,4-dihydroxyphenylalanine) is a biological precursor of the neurotransmitter dopamine and has been the "gold standard" in the treatment of Parkinsons disease for over 50 years. The widespread use
Denis А. Abaimov, Ekaterina Yu. Fedotova, Vsevolod V. Poleshchuk, Maksim N. Andreev, Oxana P. Trifonova, Petr G. Lokhov, Sergey N. Illarioshkin   +6 more
doaj   +1 more source

Studies on the growth hormone of plants. VI. The distribution of the growth substance in plant tissues [PDF]

, 1934
1. It is shown that when plant tissues are ground with water the growth substance contained therein is inactivated by the oxidizing enzymes. 2.
Thimann, Kenneth V.
core   +2 more sources

l-3,4-Dihydroxyphenylalanine induces ptosis through a GPR143-independent mechanism in mice

Journal of Pharmacological Sciences, 2016
Through its conversion to dopamine by aromatic l-amino acid decarboxylase (AADC), l-3,4-dihydroxyphenylalanine (l-DOPA) replenishes depleted brain dopamine in Parkinson's disease patients. We recently identified GPR143 as a candidate receptor for l-DOPA.
Suguru Ueda, Daiki Masukawa, Motokazu Koga, Yoshio Goshima   +3 more
doaj   +1 more source

A systematic review of biomarkers for disease progression in Parkinson's disease [PDF]

, 2013
Peer reviewedPublisher ...
A Winogrodzka, AJ Hughes, Biomarkers Definitions Working Group, C Huang, Carl E Counsell, CE Clarke, CE Clarke, CG Goetz, Consensus report of the Working Group on, D Twelves, David E Wright, David JM McGhee, DB Calne, DG Altman, DJ Brooks, DJ Gelb, H Brown, JC Hobart, John P Zajicek, KS Taylor, LM McShane, M Roth, M Yamamoto, MF Folstein, MJ Firbank, O Rascol, Pamela L Royle, Parkinson Study Group, Paul A Thompson, RJ Temple, S Fahn, SJ Huber, V Bewick, WJ Weiner   +33 more
core   +2 more sources