Results 61 to 70 of about 261 (135)

Novel 2,5-Diketopiperazines with In Vitro Activities against Protozoan Parasites of Tropical Diseases

Pharmaceuticals
Malaria, Chagas disease, and leishmaniasis are tropical diseases caused by protozoan parasites of the genera Plasmodium, Trypanosoma and Leishmania, respectively.
Isabela P. Ceravolo, Letícia F. Leoni, Antoniana U. Krettli, Silvane M. F. Murta, Daniela de M. Resende, Mariza G. F. de M. L. Cruz, Jodieh O. S. Varejão, Lorena L. Mendes, Eduardo V. V. Varejão, Markus Kohlhoff   +9 more
doaj   +1 more source

New Angucyclines and Antimicrobial Diketopiperazines from the Marine Mollusk-Derived Actinomycete An 113

Natural Product Communications, 2010
Two new angucyclines, saccharothrixmicines A ( 2 ) and B ( 3 ), together with three known diketopiperazines 4-6 were isolated from the actinomycete Saccharothrix espanaensis An 113 associated with the marine mollusk Anadara broughtoni.
Nataliya I. Kalinovskaya, Anatoly I. Kalinovsky, Lyudmila A. Romanenko, Pavel S. Dmitrenok, Tatyana A. Kuznetsova   +4 more
doaj   +1 more source

Diketopiperazines and arylethylamides produced by Schizophyllum commune, an endophytic fungus in Alchornea glandulosa

Eclética Química, 2019
Chemical investigation of the crude PDB extract obtained from the endophytic fungus Schizophyllum commune afforded the pure substances, cyclo(L-Pro-L-Val) (1), uracil (2), cyclo(Pro-Tyr) (3), p-hydroxybenzoic acid (4) and a mixture of Rel.cyclo(Pro-Phe) (
Carolina Rabal Biasetto, Andressa Somensi, Fernanda Sales Figueiro, Luiz Alberto Beraldo de Moraes, Geraldo Humberto Silva, Maria Claudia Marx Young, Vanderlan da Silva Bolzani, Angela Regina Araújo   +7 more
doaj   +1 more source

Structures and Absolute Configurations of Diketopiperazine Alkaloids Chrysopiperazines A–C from the Gorgonian-Derived Penicillium chrysogenum Fungus

Marine Drugs, 2019
Three new diketopiperazine alkaloids, including two oxepine-containing diketopiperazines, chrysopiperazines A and B (1 and 2), and one quinazoline-containing diketopiperazine, chrysopiperazine C (5), together with three known analogues (3, 4, and 6 ...
Wei-Feng Xu, Ning Mao, Xiao-Jia Xue, Yue-Xuan Qi, Mei-Yan Wei, Chang-Yun Wang, Chang-Lun Shao   +6 more
doaj   +1 more source

Chemical Constituents and Anticancer Activities of Marine-Derived Fungus Trichoderma lixii

Molecules
The fungal genus Trichoderma is a rich source of structurally diverse secondary metabolites with remarkable pharmaceutical properties. The chemical constituents and anticancer activities of the marine-derived fungus Trichoderma lixii have never been ...
Natchanun Sirimangkalakitti, Jianyu Lin, Kazuo Harada, Andi Setiawan, Mitsuhiro Arisawa, Masayoshi Arai   +5 more
doaj   +1 more source

Electron Transfer-Induced Coupling of Haloarenes to Styrenes and 1,1-Diphenylethenes Triggered by Diketopiperazines and Potassium tert-Butoxide

Molecules, 2015
The coupling of haloarenes to styrenes and 1,1-diarylethenes has been achieved with potassium tert-butoxide in the presence of N,N'-dialkyldiketopiperazines.
Eswararao Doni, Shengze Zhou, John A. Murphy   +2 more
doaj   +1 more source

A Metabolomic Study of the Variability of the Chemical Composition of Commonly Consumed Coffee Brews

Metabolites, 2019
Coffee drinking has been associated with a lower risk of certain chronic diseases and overall mortality. Its effects on disease risk may vary according to the type of coffee brew consumed and its chemical composition.
Joseph A. Rothwell, Erikka Loftfield, Roland Wedekind, Neal Freedman, Callie Kambanis, Augustin Scalbert, Rashmi Sinha   +6 more
doaj   +1 more source

Restraining Staphylococcus aureus Virulence Factors and Quorum Sensing through Lactic Acid Bacteria Supernatant Extracts

Antibiotics
The escalating prevalence of antibiotic-resistant bacteria poses a grave threat to human health, necessitating the exploration of novel alternatives to conventional antibiotics.
Myriam Anabel Díaz, Esteban Gabriel Vega-Hissi, María Amparo Blázquez, María Rosa Alberto, Mario Eduardo Arena   +4 more
doaj   +1 more source

Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins

Beilstein Journal of Organic Chemistry, 2018
A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary ...
Robby Vroemans, Fante Bamba, Jonas Winters, Joice Thomas, Jeroen Jacobs, Luc Van Meervelt, Jubi John, Wim Dehaen   +7 more
doaj   +1 more source

Four New Pairs of MetO-Containing Diketopiperazine Enantiomers: Isolation, Synthesis and Potential Anti-Parkinson’s Disease Activity

Marine Drugs
Four new methionine sulfoxide-containing diketopiperazines, (+)-dysidmetsulfoxide A [(+)-1], (+)-dysidmetsulfoxide B [(+)-2], (+)-dysidmetsulfoxide C [(+)-3] and (−)-dysidmetsulfoxide C [(−)-3], were isolated from the South China Sea sponge Dysidea sp ...
Yu Lei, Zhenyu Yang, Daichun Li, Xiaojian Liao, Chamari Hettiarachchi, Bingxin Zhao, Shihai Xu   +6 more
doaj   +1 more source