Results 41 to 50 of about 3,824 (213)

Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups

Angewandte Chemie International Edition, EarlyView.
A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari, Leon F. Schwarz, Luca Schlautmann, Kai Schließmann, Christopher Slotman, Nina von Felten, Claus‐Michael Lehr, Rolf Müller, Alexander F. Kiefer, Jörn Piel, Florian Hubrich   +10 more
wiley   +1 more source

Antifungal activity of diketopiperazines.

, 2014
–no activity up to 1000 µg/ml.Antifungal activity of diketopiperazines.
Sreerag Ravikumar Sreekala (621798), Ruby John Anto (561071), Sasidharan Nishanth Kumar (621797), Bala Nambisan (621800), Dileep Chandrasekaran (621799)   +4 more
core   +1 more source

Antibiotic Activity of a Paraphaeosphaeria sporulosa-Produced Diketopiperazine against Salmonella enterica

Journal of Fungi, 2020
A diketopiperazine has been purified from a culture filtrate of the endophytic fungus Paraphaeosphaeria sporulosa, isolated from healthy tissues of strawberry plants in a survey of microbes as sources of anti-bacterial metabolites. Its structure has been
Raffaele Carrieri, Giorgia Borriello, Giulio Piccirillo, Ernesto Lahoz, Roberto Sorrentino, Michele Cermola, Sergio Bolletti Censi, Laura Grauso, Alfonso Mangoni, Francesco Vinale   +9 more
doaj   +1 more source

Dietary Artificial Sweeteners: From Chemical Transformation in Food to Gut Microbial Processing

ChemFoodChem, EarlyView.
This review article unites classical and recent findings on the stability of artificial sweeteners in food. The focus is on ten sweeteners approved in the European Union: their chemical stability during processing and storage, individual degradation products, and their interactions with the intestinal microbiota.
Jürgen Lassak, Michael Hellwig
wiley   +1 more source

Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines

, 2018
Herein, we report a convenient synthesis of unprecedented aza-diketopiperazines (aza-DKPs). The strategy is based on selective diversification of bicyclic aza-DKP scaffolds by click reaction, N-acylation, and/or N-alkylation.
Bonnet, Dominique, Florent Péron (2096215), Brigitte Lesur, Stéphanie Riché, Riché, Stéphanie, Girard, Nicolas, Philippe Breton (5949404), Nicolas Girard, Lesur, Brigitte, Marcel Hibert (236355), Philippe Breton, Dominique Bonnet (236351), Péron, Florent, Dominique Bonnet, Stéphanie Riché (1821982), Florent Péron, Jean-Marie Fourquez (2886854), Jean-Marie Fourquez, Fourquez, Jean-Marie, Marcel Hibert, Breton, Philippe, Brigitte Lesur (2640088), Nicolas Girard (321735), Hibert, Marcel   +23 more
core   +1 more source

In Silico Evaluation of Diketopiperazine (DPK) Derivatives as Potential Inhibitors for G-Protein-Coupled Receptors (GPCRs)

Medical Sciences Forum
G-protein-coupled receptors (GPCRs) are a group of various membrane proteins that mediate essential physiological processes by translating extracellular signals into intracellular responses.
Sepideh Jafari, Joanna Bojarska
doaj   +1 more source

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Convergent Synthesis of Complex Diketopiperazines Derived from Pipecolic Acid Scaffolds and Parallel Screening against GPCR Targets

, 2016
A convergent approach to highly functionalized diketopiperazines (DKPs) using enantioenriched pipecolic acids is described. Scandium triflate-catalyzed [4 + 2] aza-annulation was employed to produce stereochemically well-defined building blocks. A resin “
John A. Porco, (2496631), Ping Lan (652758), Aaron B. Beeler (1317585), Athier Abbas (2520337), Sivaraman Dandapani (1283295), Scott Beischel (2520340), James S. Panek (1323888), Bryan L. Roth (143613)   +7 more
core   +4 more sources