Results 41 to 50 of about 261 (135)

Secondary Metabolites from Marine-Derived Fungi and Actinobacteria as Potential Sources of Novel Colorectal Cancer Drugs

Marine Drugs, 2022
Colorectal cancer is one of the most common cancers diagnosed in the world. Chemotheraphy is one of the most common methods used for the pharmacological treatment of this cancer patients.
Elin Julianti, Ikram Ammar Abrian, Marlia Singgih Wibowo, Muhammad Azhari, Nadya Tsurayya, Fauzia Izzati, Ario Betha Juanssilfero, Asep Bayu, Siti Irma Rahmawati, Masteria Yunovilsa Putra   +9 more
doaj   +1 more source

Conformationally Defined Alkaloidal Building Units for the Controlled Formation of Nanoscale Supramolecular Morphologies

Chemistry – An Asian Journal, Volume 21, Issue 10, 27 May 2026.
Structural and stereochemical modulation of diketopiperazine (DKP)–fused bispyrrolidinoindoline (BPI) building units enables precise control of conformation and intermolecular interactions, achieving well‐ordered nanoscale morphologies. Substituents and configuration variations control the morphology of BPI–DKP assemblies, producing block‐like or ...
Fumi Oki, Shunsuke Murakami, Tasuku Honda, Satoshi Yoshida, Saori Maki‐Yonekura, Jungmin Kang, Kensuke Tono, Koji Yonekura, Sota Sato, Hiroki Oguri   +9 more
wiley   +1 more source

Singlet Fission in Push–Pull Para‐Azaquinodimethane Films under the Gaze of Time Resolved Optical and Magnetic Spectroscopy

Angewandte Chemie, Volume 138, Issue 6, 2 February 2026.
New push–pull para‐azaquinodimethane derivatives were synthetized through a sustainable protocol. Transient absorption results showed ultrafast intermolecular singlet fission (SF) in film and demonstrated for AsOMe higher triplet energy than for literature SF materials, with intriguing perspectives for photovoltaics toward silicon matched SF.
Martina Alebardi, Angelo Carella, Alessandro Grasso, Enrico Sorbelli, Francesco Lazzarin, Cristina Munzone, Cosimo Gianluca Fortuna, Fausto Elisei, Anna Spalletti, Carmela Bonaccorso, Marilena Di Valentin, Benedetta Carlotti   +11 more
wiley   +2 more sources

Antimicrobial and Biofilm Inhibiting Diketopiperazines

Current Medicinal Chemistry, 2012
Diketopiperazines are the smallest cyclic peptides known. 90% of Gram-negative bacteria produce diketopiperazines and they have also been isolated from Gram-positive bacteria, fungi and higher organisms. Biosynthesis of cyclodipeptides can be achieved by dedicated nonribosomal peptide synthetases or by a novel type of synthetases named cyclopeptide ...
de Carvalho, M P, Abraham, Wolf-Rainer
openaire   +3 more sources

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

The Fluorescence of Tyrosyl and Tryptophanyl Diketopiperazines

Journal of Biological Chemistry, 1968
Abstract The influence of the peptide group on the quantum yield of phenol and indole has been evaluated from fluorescence measurements on the diketopiperazines of the two chromophores. Strong quenching of both groups occurs in water which is almost completely eliminated in dioxane and dimethyl sulfoxide.
H, Edelhoch, R S, Bernstein, M, Wilchek
openaire   +2 more sources

Safety of nonapeptide–pentapeptide mixture as a novel food pursuant to regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on a nonapeptide–pentapeptide mixture as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is a mixture composed of a 1:1 combination of nonapeptide and pentapeptide.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Thomas Frenzel, Francesca Marcon, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Alexandros Siskos, Marcello Laganaro, Irene Nuin Garciarena, Francesco Suriano, Areti Favata, Anna‐Maria Pieger, Francesca Seminati, Karen Ildico Hirsch‐Ernst   +28 more
wiley   +1 more source

In vivo characterization of the activities of novel cyclodipeptide oxidases: new tools for increasing chemical diversity of bioproduced 2,5-diketopiperazines in Escherichia coli

Microbial Cell Factories, 2020
Background Cyclodipeptide oxidases (CDOs) are enzymes involved in the biosynthesis of 2,5-diketopiperazines, a class of naturally occurring compounds with a large range of pharmaceutical activities. CDOs belong to cyclodipeptide synthase (CDPS)-dependent
Fabien Le Chevalier, Isabelle Correia, Lucrèce Matheron, Morgan Babin, Mireille Moutiez, Nicolas Canu, Muriel Gondry, Olivier Lequin, Pascal Belin   +8 more
doaj   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, Volume 38, Issue 22, 17 April 2026.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Prebiotic Organic Chemistry of Diketopiperazines

Asian Journal of Organic Chemistry, Volume 15, Issue 4, April 2026.
Diketopiperazines (DKPs) are considered essential in many life forms, but their prebiotic importance has not been fully understood. This review aims to discuss prebiotic organic chemistry for experimentally and computationally simulated reactions involving DKPs. ABSTRACT Even though the significance of amino acids and polypeptides is well recognized in
Jun Ohata
wiley   +1 more source