Results 21 to 30 of about 3,824 (213)
Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
Molecules, 2021 Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide ...
Marco Scarel, Silvia Marchesan
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Biomolecules, 2021 Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of peptides widespread in nature, are unsurpassed in their structural and bio-functional diversity. DKPs, especially those containing proline, due to their unique features
Joanna Bojarska +11 more
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Probing Anti-Leukemic Metabolites from Marine-Derived Streptomyces sp. LY1209
Metabolites, 2022 The unmet need for specific anti-leukemic agents for the treatment of acute lymphoblastic leukemia led us to screen a variety of marine-derived bacteria. The fermentation broth extract of Streptomyces sp.
You-Ying Chen +11 more
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Marine Drugs, 2022 Three new tripeptide derivatives asterripeptides A–C (1–3) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques.
Elena V. Girich +9 more
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Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction. [PDF]
PLoS ONE, 2015 The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 mutations resulting in a loss of its function. In tumours that retain wild-type p53 function, p53 activity is down-regulated by MDM2 (human murine double ...
Mariell Pettersson +8 more
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Molecules, 2022 An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields.
Parul Sahrawat +6 more
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Natural Product Communications, 2016 Diketopiperazines, natural products found in bacteria, fungi, marine sponges, gorgonian and red algae, are cyclic dipeptides possessing relatively simple and rigid structures with chiral nature and various side chains.
Hyukjae Choi, Sae-Kwang Ku, Jong-Sup Bae
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Marine Drugs, 2023 The fungal strain BC17 was isolated from sediments collected in the intertidal zone of the inner Bay of Cadiz and characterized as Emericellopsis maritima.
Jorge R. Virués-Segovia +10 more
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New Metabolites from the Marine Sponge Scopalina hapalia Collected in Mayotte Lagoon
Marine Drugs, 2022 The biological screening of 44 marine sponge extracts for the research of bioactive molecules, with potential application in the treatment of age-related diseases (cancer and Alzheimer’s disease) and skin aging, resulted in the selection of Scopalina ...
Charifat Saïd Hassane +13 more
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Molecules, 2014 Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4'',3'':4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence.
Barbara Parrino +6 more
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