Results 11 to 20 of about 261 (135)
Molecules, 2017 Diketopiperazines can be generated by non-enzymatic cyclization of linear dipeptides at extreme temperature or pH, and the complex medium used to culture bacteria and fungi including phytone peptone and trypticase peptone, can also produce cyclic ...
Michelli Massaroli da Silva +10 more
doaj +1 more source
Marine Drugs, 2023 The fungal strain BC17 was isolated from sediments collected in the intertidal zone of the inner Bay of Cadiz and characterized as Emericellopsis maritima.
Jorge R. Virués-Segovia +10 more
doaj +1 more source
New Metabolites from the Marine Sponge Scopalina hapalia Collected in Mayotte Lagoon
Marine Drugs, 2022 The biological screening of 44 marine sponge extracts for the research of bioactive molecules, with potential application in the treatment of age-related diseases (cancer and Alzheimer’s disease) and skin aging, resulted in the selection of Scopalina ...
Charifat Saïd Hassane +13 more
doaj +1 more source
Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction. [PDF]
PLoS ONE, 2015 The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 mutations resulting in a loss of its function. In tumours that retain wild-type p53 function, p53 activity is down-regulated by MDM2 (human murine double ...
Mariell Pettersson +8 more
doaj +1 more source
Natural Product Communications, 2016 Diketopiperazines, natural products found in bacteria, fungi, marine sponges, gorgonian and red algae, are cyclic dipeptides possessing relatively simple and rigid structures with chiral nature and various side chains.
Hyukjae Choi, Sae-Kwang Ku, Jong-Sup Bae
doaj +1 more source
Molecules, 2012 The well-known Ugi reaction of aldehydes with amines, carboxylic acids and isocyanides leads to the formation of acyclic α-acylaminocarboxamides. Replacement of the carboxylic acid derivatives with β-acyl substituted acrylic acids gives
Ulrike Holzgrabe +4 more
doaj +1 more source
Marine Drugs, 2020 Four new indolyl diketopiperazines, aspamides A–E (1–4) and two new diketopiperazines, aspamides F–G (5–6), along with 11 known diketopiperazines and intermediates were isolated from the solid culture of Aspergillus versicolor, which is an endophyte with
Yi Ding +5 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Farnesol, a self-secreted quorum-sensing molecule (QSM) of Candida albicans, has been known to limit yeast-to-hyphal transition by blocking the RAS1–cAMP–PKA pathway.
Ravi Jothi +3 more
doaj +1 more source
Molecules, 2014 Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4'',3'':4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence.
Barbara Parrino +6 more
doaj +1 more source
Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
Molecules, 2021 Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide ...
Marco Scarel, Silvia Marchesan
doaj +1 more source