Results 11 to 20 of about 3,824 (213)

Antimicrobial and Biofilm Inhibiting Diketopiperazines [PDF]

Current Medicinal Chemistry, 2012
Diketopiperazines are the smallest cyclic peptides known. 90% of Gram-negative bacteria produce diketopiperazines and they have also been isolated from Gram-positive bacteria, fungi and higher organisms. Biosynthesis of cyclodipeptides can be achieved by dedicated nonribosomal peptide synthetases or by a novel type of synthetases named cyclopeptide ...
de Carvalho, M P, Abraham, Wolf-Rainer
core   +5 more sources

A Simple Defined Medium for the Production of True Diketopiperazines in Xylella fastidiosa and Their Identification by Ultra-Fast Liquid Chromatography-Electrospray Ionization Ion Trap Mass Spectrometry

Molecules, 2017
Diketopiperazines can be generated by non-enzymatic cyclization of linear dipeptides at extreme temperature or pH, and the complex medium used to culture bacteria and fungi including phytone peptone and trypticase peptone, can also produce cyclic ...
Michelli Massaroli da Silva, Moacir dos Santos Andrade, Anelize Bauermeister, Marcus Vinícius Merfa, Moacir Rossi Forim, João Batista Fernandes, Paulo Cezar Vieira, Maria Fátima das Graças Fernandes da Silva, Norberto Peporine Lopes, Marcos Antônio Machado, Alessandra Alves de Souza   +10 more
doaj   +2 more sources

One-Pot Ugi/Aza-Michael Synthesis of Highly Substituted 2,5-Diketopiperazines with Anti-Proliferative Properties

Molecules, 2012
The well-known Ugi reaction of aldehydes with amines, carboxylic acids and isocyanides leads to the formation of acyclic α-acylaminocarboxamides. Replacement of the carboxylic acid derivatives with β-acyl substituted acrylic acids gives
Ulrike Holzgrabe, Viktoria H. Gessner, Florian Seufert, Carsten Berges, Andreas Hartung   +4 more
doaj   +2 more sources

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines

The Journal of Organic Chemistry, 2017
Aza-diketopiperazines (aza-DKPs) represent an underprivileged motif obtained by scaffold hopping of 2,5-diketopiperazines (2,5-DKPs). Herein, we compare the synthesis and the structural and physicochemical properties of aza-DKP 4 vs 2,5-DKP 7. Thus, X-ray and 1H NMR studies show that aza-DKP 4 is a rigid and nonflat scaffold like the 2,5-DKP 7 ...
Regenass, Pierre, Bosc, Damien, Riché, Stéphanie, Gizzi, Patrick, Hibert, Marcel, Karmazin, Lydia, Ganesan, A., Bonnet, Dominique   +7 more
core   +7 more sources

Bioactive Indolyl Diketopiperazines from the Marine Derived Endophytic Aspergillus versicolor DY180635

Marine Drugs, 2020
Four new indolyl diketopiperazines, aspamides A–E (1–4) and two new diketopiperazines, aspamides F–G (5–6), along with 11 known diketopiperazines and intermediates were isolated from the solid culture of Aspergillus versicolor, which is an endophyte with
Yi Ding, Xiaojing Zhu, Liling Hao, Mengyao Zhao, Qiang Hua, Faliang An   +5 more
doaj   +2 more sources

Escherichia coli GutM4 produces 2,5-diketopiperazines and inhibits human pathogens in vitro

Electronic Journal of Biotechnology, 2017
Background: It has been a very common practice to use probiotics or their metabolites as alternative antimicrobial strategies for the treatment and prevention of infections as rampant and indiscriminate use of antibiotics causes the development of ...
Xichun Zhang, Junmin Du, Yu Wang, Shuming Chen, Yingli Wang   +4 more
doaj   +2 more sources

Bitter 2,5-Diketopiperazines From Cocoa Activate Human Bitter Taste Receptors. [PDF]

Mol Nutr Food Res
Thermal processing of protein‐containing food leads to the formation of cyclic dipeptides, called 2,5‐diketopiperazines (DKPs). These molecules often contribute to a bitter note in food. Despite the impact of DKPs on the taste of important food groups, their detection by human bitter taste receptors remained enigmatic.
Schaefer S, Luna A, Behrens M.
europepmc   +2 more sources

Nicotinamide and Sodium Butyrate Double the Pool of Treatment-Exclusive Metabolites in the Endophytic Fungus Curvularia sp. G6-32. [PDF]

Chem Biodivers
Epigenetic modulators nicotinamide and sodium butyrate reshape the chemical landscape of the endophytic fungus Curvularia sp. G6‐32. Combining the OSMAC strategy with UHPLC‐MS/MS metabolomics and molecular networking reveals a more than twofold rise in treatment‐exclusive metabolites, including diketopiperazines and potentially bioactive natural ...
Pega GEA, Nicchio LSP, Polli AD, Valeze FAP, Oliveira ÉL, Meurer EC, Baldoqui DC, Azevedo JL, Polonio JC.   +8 more
europepmc   +2 more sources

Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

Nature Communications, 2020
Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are bioactive natural products that are difficult to access chemically. Here, the authors identify a family of three related HTDKP-forming cytochrome P450s and engineer key amino ...
Chenghai Sun, Zhenyao Luo, Wenlu Zhang, Wenya Tian, Haidong Peng, Zhi Lin, Zixin Deng, Bostjan Kobe, Xinying Jia, Xudong Qu   +9 more
doaj   +1 more source

Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines

, 2022
Antimicrobial drug resistance is a looming health crisis facing us in the modern era, and new drugs are urgently needed to combat this growing problem. Synthetic mimics of antimicrobial peptides have recently emerged as a promising class of compounds for
Homayon J. Arabshahi (3809704), Sonya Mros (12354027), Johan Svenson, Thomas M. Grant (12354021), Alan Cameron (481829), Homayon J. Arabshahi, Patrick Cahill (346785), Johan Svenson (1744942), David Rennison (2338186), Thomas M. Grant, David Rennison, Scott A. Ferguson (6812180), Alexandra L. Krause, Sonya Mros, Margaret A. Brimble, Margaret A. Brimble (574926), Scott A. Ferguson, Gregory M. Cook, Alexandra L. Krause (12354024), Alan Cameron, Gregory M. Cook (7319351), Patrick Cahill   +21 more
core   +1 more source