Results 51 to 60 of about 15,827 (239)

Pharmacogenetic Testing as a Tool to Prevent Isoniazid-Induced Hepatotoxicity in Pulmonary Tuberculosis Therapy: A Case Report

Безопасность и риск фармакотерапии
INTRODUCTION. Hepatotoxicity is the leading cause of isoniazid discontinuation, significantly reducing the efficacy of antituberculosis therapy, increasing the risk of disease relapse, and contributing to secondary drug resistance in Mycobacterium ...
N. M. Krasnova, E. A. Emelyanova, A. A. Egorova, E. S. Prokopyev, A. I. Vengerovskii, D. A. Sychev   +5 more
doaj   +1 more source

Üniversitelerdeki Türk Dili Derslerinin Dünü, Bugünü, Yarını (Sorunlar-Çözüm Önerileri) Çalıştayı

Skad, 2023
Bu yazı Sakarya Üniversitesi Rektörlük-Türk Dili Bölümü tarafından 26 Eylül 2023 tarihinde yapılan "Üniversitelerdeki Türk Dili derslerinin Dünü, Bugünü, Yarını (Sorunlar-Çözüm Önerileri)" adlı çalıştayı konu almaktadır.
Hürdünya Şahan, Özlem Düzlü
doaj  

From politics to economics: The investigation of the determinants of local administrative hierarchy in the Tang–Song transition

Asia‐Pacific Economic History Review, Volume 65, Issue 1, Page 39-78, March 2025.
Abstract This study collects original data to examine the determinants of classification criteria of county hierarchy and its rank variations during the Tang–Song period. The results reveal that the county hierarchy was affected by both economic and political situations, with more emphasis on politics in Tang and economics in Song.
Nan Li, Heqi Cai
wiley   +1 more source

The Influence of Regional Government and Community Participation on the Development of Spiritual Tourism in Pante Makasar, Timor-Leste

International Journal of Home Economics, Hospitality and Allied Research
This study examines the role of government and community participation in the development of spiritual tourism in Pante Makassar, Oe-Cusse Municipality, Timor-Leste.
Cevat Tosun, Jacinto Colo, Helio Brites da Silva   +2 more
doaj   +1 more source

Combined analysis of 16S rDNA sequencing and metabolomics to find biomarkers of drug-induced liver injury

Scientific Reports, 2023
Drug induced liver injury (DILI) is a kind of liver dysfunction which caused by drugs, and gut microbiota could affect liver injury. However, the relationship between gut microbiota and its metabolites in DILI patients is not clear.
Kaini He, Mimi Liu, Qian Wang, Sijie Chen, Xiaoyan Guo   +4 more
doaj   +1 more source

Autoimmune Hepatitis: Histopathological Diversity and Its Clinical Implications

Hepatology Research, EarlyView.
ABSTRACT Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease characterized by diverse clinical and histological manifestations. Accurate histopathological evaluation plays a critical role in determining disease activity, guiding treatment strategies, and predicting prognosis.
Mina Komuta, Kenichi Harada
wiley   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

Multi-Stakeholder Engagement in Community-Based Tourism Development: Evidence from Pante Makassar, Timor-Leste

International Journal of Home Economics, Hospitality and Allied Research
This study examined the stakeholders' engagement in Community-Based Tourism (CBT) in Pante Makassar, Oe-Cusse, Timor-Leste. The stakeholders included the local community, the private sector, tourists, and the local government.
Cevat Tosun, Nicolao Salvador Marques, Helio Brites da Silva   +2 more
doaj   +1 more source

Short communication: Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA‐122 in hospital clinical laboratories

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 612-618, February 2026.
MicroRNA‐122 (miR‐122) is a sensitive biomarker for paracetamol‐induced liver injury. This study assessed the diagnostic performance of dynamic chemical labelling (DCL) combined with an immunoassay platform to quantify miR‐122 in human serum, as a proof‐of‐concept for hospital use.
Samar Alzeer, Antonio Marin‐Romero, Bárbara López‐Longarela, Juan J. Guardia‐Monteagudo, F. Javier Lopez‐Delgado, Salvatore Pernagallo, Juan J. Diaz‐Mochon, Mavys Tabraue‐Chavez, Kathleen Scullion, James W. Dear   +9 more
wiley   +1 more source

Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures

Frontiers in Pharmacology, 2020
Drug-induced liver injury (DILI) is one of the major reasons for termination of drug development. Due to the importance of predicting DILI in early phases of drug development, diverse in silico models have been developed to filter out DILI-causing ...
Hyun Kil Shin, Myung-Gyun Kang, Daeui Park, Daeui Park, Tamina Park, Tamina Park, Seokjoo Yoon, Seokjoo Yoon   +7 more
doaj   +1 more source