Results 141 to 150 of about 4,480 (170)

Rheological characterization of diltiazem HCl/cellulose wet masses using a mixer torque rheometer

International Journal of Pharmaceutics, 1998
Abstract The objective of the present investigations was to study the rheological behavior of wet powder masses containing two commonly used cellulose ethers, hydroxypropyl methylcellulose (HPMC) and hydroxyethyl cellulose (HEC), using a mixer torque rheometer.
Ramarao Chatlapalli, Bhagwan D. Rohera
exaly   +2 more sources

Modulation of Drug Release Rate of Diltiazem–HCl from Hydrogel Matrices of Succinic Acid-Treated Ispaghula Husk

Pharmaceutical Development and Technology, 2000
The feasibility of using succinic acid-treated ispaghula husk in matrix-based tablets of diltiazem-HCl was investigated. The sample prepared using 4:1 weight ratio of ispaghula husk to succinic acid showed improved swelling and gelling. A 3(2) factorial design was employed to investigate the effect of amount of succinic acid-treated ispaghula husk and ...
M C, Gohel, A F, Amin, M T, Chhabaria, M K, Panchal, A N, Lalwani   +4 more
exaly   +3 more sources

Development and Evaluation of Controlled-Release Diltiazem HCl Microparticles Using Cross-Linked Poly(Vinyl Alcohol)

Drug Development and Industrial Pharmacy, 1997
AbstractHydrogels of cross-linked poly (vinyl alcohol) (PVA) were developed and their properties were evaluated as a controlled-release oral solid dosage form. The concentration of glutaraldehyde involved in cross-linking is directly proportional to the compactness of the three-dimensional networks of the cross-linked PVA.
Dushyant Shah, Yamini Shah, Ram Pradhan
exaly   +2 more sources

Diltiazem HCl suppresses porcine reproductive and respiratory syndrome virus infection in susceptible cells and in swine

Veterinary Microbiology
Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen for swine, resulting in substantial economic losses to the swine industry. However, there has been little success in developing effective vaccines or drugs for PRRSV control. In the present study, we discovered that Diltiazem HCl, an inhibitor of L-type Ca2+ channel, effectively ...
Liangliang, Li, Jiayu, Wang, Li, Chen, Qinghai, Ren, Muhammad Faheem, Akhtar, Wenhua, Liu, Changfa, Wang, Shengliang, Cao, Wenqiang, Liu, Qin, Zhao, Yubao, Li, Tongtong, Wang   +11 more
exaly   +3 more sources

Liposomal diltiazem HCl as ocular drug delivery system for glaucoma

Drug Development and Industrial Pharmacy, 2013
In this study, unilamellar liposomal vesicles of diltiazem HCl (DH) were prepared using either reversed phase evaporation (REV) or proliposome methods. Soya phosphatidylcholine (SPC) was used for preparing the liposomes, and the vesicles were rigidified using cholesterol (Chol) or cetyl alcohol (CA) in different molarities.
Mahmoud, Mokhtar Ibrahim, Salma A H, Tawfique, Mahmoud M, Mahdy   +2 more
openaire   +2 more sources

Chronotherapy of Cardiac Diseases using Diltiazem HCl-A Review

Research Journal of Pharmacy and Technology, 2015
Hypertension is associated with increased cardio and cerebrovascular morbidity and mortality; antihypertensive drugs have been shown to reduce the risk of adverse cardio and cerebrovascular events. These events tend to be more common during the morning hours, a time when both normo and hypertensives show a circadian peak in blood pressure (BP ...
V. Kamalakkannan, K.S.G. Arul Kumaran, P. Meena Prabha, R. Sambathkumar   +3 more
openaire   +1 more source

Validation of manufacturing process of Diltiazem HCl tablets by NIR spectrophotometry (NIRS)

Journal of Pharmaceutical and Biomedical Analysis, 2007
The goal of this study was to apply the Process Analytical Technology FDA's initiative in pharmaceutical tablets manufacturing. Near Infrared Spectrophotometry (NIRS) was used as a non-destructive, very fast technique requiring no sample preparation. Direct compression powder blends containing Diltiazem HCl as a model drug were pressed into tablets for
Bodson, Cédric, Rozet, Eric, Ziemons, Eric, Evrard, Brigitte, Hubert, Philippe, Delattre, Luc   +5 more
openaire   +2 more sources

A combination of nonionic surfactants and iontophoresis to enhance the transdermal drug delivery of ondansetron HCl and diltiazem HCl

European Journal of Pharmaceutics and Biopharmaceutics, 2012
The present work reports the evaluation of three nonionic ether-monohydroxyl surfactants (C(12)E(1), C(12)E(5,) and C(12)E(8)) as skin permeation enhancers in the transdermal drug delivery of two drugs: ondansetron hydrochloride and diltiazem hydrochloride, formulated as hydrogels. The enhancers are used alone, or in combination with iontophoresis (0.3
Sérgio M C, Silva, Longsheng, Hu, João J S, Sousa, Alberto A C C, Pais, Bozena B, Michniak-Kohn   +4 more
openaire   +2 more sources

Development of Modified Release Diltiazem HCl Tablets Using Composite Index to Identify Optimal Formulation

Drug Development and Industrial Pharmacy, 2003
This article reports the preparation of tartaric acid treated ispaghula husk powder for the development of modified release tablets of diltiazem HCl by adopting direct compression technique and a 32 full factorial design. The modified ispaghula husk powder showed superior swelling and gelling as compared to untreated powder.
M C, Gohel, M M, Patel, A F, Amin
openaire   +2 more sources

[A comparison between diltiazem SR and diltiazem HCL in the treatment of angina pectoris].

Zhonghua nei ke za zhi, 1993
This study included 168 patients with angina pectoris, who were divided into two groups, the diltiazem SR (No. 88) group and diltiazem HCL (No. 80) group. The two groups were comparable in age and duration of coronary heart disease. The results were as follows: (1) The total clinical effect of diltiazem SR (94.3%) was slightly greater than that of ...
X S, Yang, Q L, Li, K, Rong
openaire   +1 more source