Results 151 to 160 of about 4,480 (170)
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A Validated UV Spectroscopic method for Quantification of Lidocaine HCl and Diltiazem HCl
A Simple and routinely used UV- Spectroscopic technique has been developed for estimating Lidocaine hydrochloride and Diltiazem hydrochloride in bulk and combined dosage form. The simultaneous estimation using first- order derivative analysis was 0.1 M HCl solvent, with scanning at wavelengths of 223 nm and 250 nm for quantifying lidocaine HCl and ...Nirali Chaudhari +4 more
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In vivo performance of controlled release pellets of diltiazem HCl.
Pakistan journal of pharmaceutical sciences, 2006The test formulation of controlled release diltiazem pellets was evaluated in vivo, in comparison with Herbesser SR. Six healthy volunteers participated in the study, conducted according to a randomized, two-way crossover study design. The preparations were compared using the pharmacokinetic parameters plasma concentration-time curve (AUC(0- infinity)),
, Nisarur-ur-Rahman +2 more
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FORMULATION AND IN VITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF DILTIAZEM HCL
2023The present study involves in the formulation and evaluation of Controlled release tablets of Diltiazem HCl (100mg). The objective of the present study was to formulate Diltiazem hcl Controlled release tablets by Direct compression method by using HPMC K 15M, HPC 2M and HEC 2M.
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Drug Development and Industrial Pharmacy, 2015
In this work, aqueous diltiazem HCl and polyvinyl-pyrrolidone (PVP) solutions were mixed with Kollicoat SR 30D and spray dried to microparticles of different drug:excipient ratio and PVP content. Co-spray dried products and physical mixtures of drug, Kollidon SR and PVP were tableted.
Nizar, Al-Zoubi +3 more
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In this work, aqueous diltiazem HCl and polyvinyl-pyrrolidone (PVP) solutions were mixed with Kollicoat SR 30D and spray dried to microparticles of different drug:excipient ratio and PVP content. Co-spray dried products and physical mixtures of drug, Kollidon SR and PVP were tableted.
Nizar, Al-Zoubi +3 more
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Clinical therapeutics, 1994
The safety and efficacy of an extended-release form of diltiazem HCl (diltiazem XR) in patients 55 years or older with mild-to-moderate essential hypertension were examined in a multi-center, double-blind, randomized, placebo-controlled, parallel-group study involving 350 patients with supine diastolic blood pressure (DBP) between 95 mm Hg and 114 mm ...
R, Fiddes +7 more
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The safety and efficacy of an extended-release form of diltiazem HCl (diltiazem XR) in patients 55 years or older with mild-to-moderate essential hypertension were examined in a multi-center, double-blind, randomized, placebo-controlled, parallel-group study involving 350 patients with supine diastolic blood pressure (DBP) between 95 mm Hg and 114 mm ...
R, Fiddes +7 more
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Pharmaceutical Development and Technology
Modified released formulations of diltiazem were previously prepared using cation-exchange resins. However, multiple excipients were required to achieve the appropriate release rate. It was of interest to prepare a modified release dosage form of diltiazem using drug-resin complex alone.Adsorption experiments conducted using a rotating bottle apparatus.
Khouloud A, Alkhamis, Suhair S, Al-Nimry
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Modified released formulations of diltiazem were previously prepared using cation-exchange resins. However, multiple excipients were required to achieve the appropriate release rate. It was of interest to prepare a modified release dosage form of diltiazem using drug-resin complex alone.Adsorption experiments conducted using a rotating bottle apparatus.
Khouloud A, Alkhamis, Suhair S, Al-Nimry
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The Journal of Clinical Pharmacology, 1993
Calcium‐channel blockers are a safe and effective treatment modality and have been used extensively in the treatment of angina and hypertension. Dilacor™ XR capsules, a new extended‐release formulation of diltiazem, has been developed for the treatment of hypertension. Dilacor XR (Rhône‐Poulenc Rorer Pharmaceuticals Inc., Collegeville, PA) uses a novel
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Calcium‐channel blockers are a safe and effective treatment modality and have been used extensively in the treatment of angina and hypertension. Dilacor™ XR capsules, a new extended‐release formulation of diltiazem, has been developed for the treatment of hypertension. Dilacor XR (Rhône‐Poulenc Rorer Pharmaceuticals Inc., Collegeville, PA) uses a novel
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1993
The primary means of administration for the vast majority of therapeutic agents is via the oral route. Many of these oral dosage forms are designed to provide a rapid disintegration in the stomach, however, over the last 5–6 years there has been a growing trend within the pharmaceutical industry to develop complex pharmaceutical dosage forms designed ...
Donald L. Heald +2 more
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The primary means of administration for the vast majority of therapeutic agents is via the oral route. Many of these oral dosage forms are designed to provide a rapid disintegration in the stomach, however, over the last 5–6 years there has been a growing trend within the pharmaceutical industry to develop complex pharmaceutical dosage forms designed ...
Donald L. Heald +2 more
openaire +1 more source