Results 21 to 30 of about 5,306 (202)

Experimental Approval of the Efficacy of the Combined Composition Rectal Cream New Test-samples in the Conditions of Acute Complicated Anal Fissure in Rats [PDF]

, 2019
Anal fissure (AF) is one of the most common anorectal problems. The severity of the disease, the chronicity of the pathological process and frequent complications lead to a sharp deterioration in the quality of life of patients. An important place in the
Stakhorska, M. (Marina), Zaychenko, G. (Ganna)   +1 more
core   +3 more sources

A survey of Top 200 Drugs—Inconsistent Practice of Drug Strength Expression for Drugs Containing Salt Forms [PDF]

, 2012
Many ionizable drugs are developed and marketed as salt forms. However, there are no clear US regulatory guidelines on drug strength labeling for salts. The strengths of some drugs are expressed as salts and some as free acids/bases.
Prohotsky, Daniel, Zhao, Fang
core   +2 more sources

Release Characteristics of Diltiazem Hydrochloride Wax-Matrix Granules – Thermal Sintering Effect

Journal of Applied Sciences and Environmental Management, 2011
The aim of this study was to investigate the release characteristics of matrix (non-disintegrating) granules consisting of diltiazem hydrochloride (model drug) and glyceryl behenate (a wax matrix forming polymer) for sustained release application using ...
MU Uhumwangho, RMKV Ramana
doaj   +1 more source

Impacts of compound properties and sediment characteristics on the sorption behaviour of pharmaceuticals in aquatic systems [PDF]

, 2016
Sorption is a key factor in determining the persistence, attenuation and bioavailability of sediment-associated contaminants. However, our understanding of the sorption behaviour of pharmaceuticals in sediments is poor. In this study, we investigated the
Al-Khazrajy, Omar S A, Boxall, Alistair B A   +1 more
core   +1 more source

Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules

Química Nova, 2011
This work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.8 as the dissolution ...
Taciane Ferreira Mendonça, Eliézer Giannini de Barros, Gislaine Ribeiro Pereira, Magali Benjamim de Araújo, Rudy Bonfilio   +4 more
doaj   +1 more source

Toxicological and ecotoxicological risk‐based prioritization of pharmaceuticals in the natural environment [PDF]

, 2016
Approximately 1500 active pharmaceutical ingredients are currently in use; however, the environmental occurrence and impacts of only a small proportion of these have been investigated.
Agerstrand, Ashton, Boxall, Boxall, Capleton, Carter, Cooper, Crane, Dong, Drillia, Escher, Fick, Franco, Fu, Halling-Sorensen, Hirsch, Kidd, Kim, Kolpin, Kostich, Lahnsteiner, Laville, Monteiro, Niemuth, Ramirez, Roberts, Rocco, Roos, Sanderson, Santos, Schwab, Schwaiger, Sinclair, Triebskorn, Triebskorn, Wang, Webb, Zha   +37 more
core   +1 more source

Aptamer-based cocaine assay using a nanohybrid composed of ZnS/Ag2Se quantum dots, graphene oxide and gold nanoparticles as a fluorescent probe [PDF]

, 2020
Authors report on a new fluoro-graphene-plasmonic nanohybrid aptamer-based fluorescent nanoprobe for cocaine. To construct the nanoprobe, newly synthesized glutathione-capped ZnS/Ag 2Se quantum dots (QDs) were first conjugated to graphene oxide (GO) to ...
Abdolvand, Amin, Adegoke, Oluwasesan, Nic Daeid, Niamh, Pereira-Barros, Magda A., Zolotovskaya, Svetlana   +4 more
core   +2 more sources

Development of a Halothane-Adrenaline Arrhythmia Model Using In Vivo Guinea Pigs

Journal of Pharmacological Sciences, 2004
In vivo antiarrhythmic effects of diltiazem hydrochloride and nifekalant hydrochloride, a pure class III antiarrhythmic drug (Vaughan Williams’ classification), on adrenaline induced ventricular arrhythmias were examined in halothane anesthetized guinea ...
Yoshiaki Noda, Keitaro Hashimoto
doaj   +1 more source

Vegetable proteins in microencapsulation: a review of recent interventions and their effectiveness [PDF]

, 2013
Proteins from vegetable seeds are interesting for research at present because they are an abundant alternative to animal-based sources of proteins and petroleum-derived polymers.
Alric, Isabelle, Durrieu, Vanessa, Nesterenko, Alla, Silvestre, Françoise   +3 more
core   +1 more source

Neuron-non-neuron electrical coupling networks are involved in chronic stress-induced electrophysiological changes in lateral habenular neurons. [PDF]

J Physiol
Abstract figure legend We investigated electrophysiological changes in lateral habenula (LHb) neurons induced by chronic social defeat stress in mice. LHb neurons exhibited short (<400 ms) rebound depolarizing potentials (short‐RDPs) or long‐RDPs (order of seconds) (long‐RDPs) after the offset of hyperpolarization. The incidence of long‐RDP neurons was
Yamaoka K, Nozaki K, Zhu M, Terai H, Kobayashi K, Ito H, Matsumata M, Takemoto H, Ikeda S, Sotomaru Y, Mori T, Aizawa H, Hashimoto K.   +12 more
europepmc   +2 more sources