Release Characteristics of Diltiazem Hydrochloride Wax-Matrix Granules – Thermal Sintering Effect [PDF]
Journal of Applied Sciences and Environmental Management, 2011 The aim of this study was to investigate the release characteristics of matrix (non-disintegrating) granules consisting of diltiazem hydrochloride (model drug) and glyceryl behenate (a wax matrix forming polymer) for sustained release application using ...
MU Uhumwangho, RMKV Ramana
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Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules [PDF]
Química Nova, 2011 This work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.8 as the dissolution ...
Taciane Ferreira Mendonça +4 more
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Pharmacokinetics of diltiazem hydrochloride delay-onset sustained-release pellet capsules in healthy volunteers [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2013 The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not
Xi-Qing Yan +7 more
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Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film [PDF]
Indonesian Journal of Pharmacy, 2021 Diltiazem hydrochloride (HCl) is a category of calcium channel blocker used as an antihypertensive agent. Diltiazem HCl is a low bioavailable drug due to high first-pass metabolism and a short half-life (3-5 hours); hence mucoadhesive buccal film was ...
Lina Winarti +2 more
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Brazilian Journal of Pharmaceutical Sciences, 2011 Diltiazem hydrochloride is a calcium channel blocker generally indicated for the treatment of angina and hypertension, and it is extensively metabolized due to the hepatic metabolism.
Swati Changdeo Jagdale +3 more
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Employing intrinsic fluorone-dye fluorescence in a quenching-based (“on-off”) strategy for diltiazem determination in tablets and capsules [PDF]
BMC ChemistryA novel green spectrofluorometric method was developed for the quantification of diltiazem hydrochloride (DLZ), a benzothiazepine-class calcium channel blocker with vasodilatory properties.
Ahmed A. Abu-hassan
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Pharmaceuticals, 2021 Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high permeability and rapid metabolism
Mosab Arafat +5 more
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Diltiazem-tetraiodide bismuthate (III) based PVC membrane for selective determination of diltiazem hydrochloride [PDF]
, 2023 A new coated-wire electrode based on PVC membrane plasticized with dioctyl phthalate (DOP) and containing the diltiazem-tetraiodido bismuthate (III) ion association coated on a silver wire was constructed and used for potentiometric determination of ...
Kassab, Ryad, Aboudan, Mahmoud
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FORMULA OPTIMIZATION AND IN VITRO RELEASE KINETIC STUDIES OF DILTIAZEM HYDROCHLORIDE MUCOADHESIVE BILAYER BUCCAL FILM [PDF]
, 2021 Objective: This research aims to determine the amount of hydroxypropyl methylcellulose (HPMC) and chitosan, which can produce the optimum buccal film formula and to determine the release kinetics of diltiazem hydrochloride in vitro. Methods: The film was
WINARTI, LINA +7 more
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Journal of Pharmaceutical Analysis, 2020 An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance. Several characterisation techniques as well as isothermal calorimetry were utilized in investigating the ...
Ana-Maria Totea +7 more
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