Results 11 to 20 of about 1,803 (117)

New Diltiazem Potentiometric Membrane Sensor Stands on Theoretical Calculations as a Useful Device for Diltiazem Hydrochloride Analysis in Pharmaceutical Formulation and Urine

International Journal of Electrochemical Science, 2008
Diltiazem, belongs to the group of drugs known as benzothiazepines, which are a class of calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia.
Mohammad Reza Ganjali, Rassoul Dinarvand, Siavash Riahi   +2 more
exaly   +3 more sources

Employing intrinsic fluorone-dye fluorescence in a quenching-based (“on-off”) strategy for diltiazem determination in tablets and capsules [PDF]

BMC Chemistry
A novel green spectrofluorometric method was developed for the quantification of diltiazem hydrochloride (DLZ), a benzothiazepine-class calcium channel blocker with vasodilatory properties.
Ahmed A. Abu-hassan
doaj   +2 more sources

Development and evaluation of diltiazem hydrochloride controlled-release pellets by fluid bed coating process

Journal of Advanced Pharmaceutical Technology & Research, 2013
The aim of the present study was to develop controlled-release pellets of diltiazem HCl with ethyl cellulose and hydroxylpropyl methylcellulose phthalate as the release rate retarding polymers by fluid bed coating technique.
Mikkilineni Bhanu Prasad, Suryadevara Vidyadhara, Reddyvalam Lankapalli C Sasidhar, Talamanchi Balakrishna, Pavuluri Trilochani   +4 more
doaj   +2 more sources

A Simple and Rapid Analytical Method to Detect and Quantify the N‐Nitroso Desmethyl Diltiazem Impurity by Liquid Chromatography‐Tandem Mass Spectrometry in Diltiazem Hydrochloride

Separation Science Plus
ABSTRACT N‐nitroso desmethyl diltiazem is a known genotoxic impurity in the cardiovascular drug product diltiazem hydrochloride, raising significant concerns due to its potential carcinogenicity. Detection of such impurities at trace levels is crucial to ensure drug safety and regulatory compliance.
Veeraswami Boddu
exaly   +2 more sources

In Vitro and In Vivo Evaluation of Oral Controlled Release Formulation of BCS Class I Drug Using Polymer Matrix System

Pharmaceuticals, 2021
Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high permeability and rapid metabolism
Mosab Arafat, Muhammad Sarfraz, Mohammad F. Bostanudin, Anna Esmaeil, Aisha Salam, Salahdein AbuRuz   +5 more
doaj   +1 more source

Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film

Indonesian Journal of Pharmacy, 2021
Diltiazem hydrochloride (HCl) is a category of calcium channel blocker used as an antihypertensive agent. Diltiazem HCl is a low bioavailable drug due to high first-pass metabolism and a short half-life (3-5 hours); hence mucoadhesive buccal film was ...
Lina Winarti, Bagus Tri Laksono, Lusia Oktora Ruma Kumala Sari   +2 more
doaj   +1 more source

Thermodynamics of clay–drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography

Journal of Pharmaceutical Analysis, 2020
An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance. Several characterisation techniques as well as isothermal calorimetry were utilized in investigating the ...
Ana-Maria Totea, Juan Sabin, Irina Dorin, Karl Hemming, Peter R. Laity, Barbara R. Conway, Laura Waters, Kofi Asare-Addo   +7 more
doaj   +1 more source

Highly stretchable gelatin‐polyacrylamide hydrogel for potential transdermal drug release

Nano Select, 2021
Stretchable hydrogels have been used for a number of biomedical applications. This research focused on the study of a highly stretchable and tough hydrogel made of gelatin and polyacrylamide towards transdermal drug delivery applications.
Zhen Qiao, Long Tran, Jesse Parks, Yao Zhao, Nan Hai, Yinghui Zhong, Hai‐Feng Ji   +6 more
doaj   +1 more source

A novel stability-indicating method for known and unknown impurities profiling for diltiazem hydrochloride pharmaceutical dosage form (tablets)

Future Journal of Pharmaceutical Sciences, 2021
Background A novel gradient, high-sensitive and specific stability-indicating reverse-phase HPLC method was developed and validated for quantitative purpose of known, unknown and degradant impurities profiling for diltiazem hydrochloride tablets.
Nitin Mahajan, Suparna Deshmukh, Mazahar Farooqui   +2 more
doaj   +1 more source

An Expired Non-Toxic Diltiazem Hydrochloride as Corrosion Inhibitor for Cu in Nitric Acid Medium

International Journal of Electrochemical Science, 2017
The corrosion inhibition of Cu in 1 M HNO3 solution by expired Diltiazem Hydrochloride (HD) has been tested by Tafel polarization, electrical frequency modulation, electrical impedance spectroscopy, and mass loss method. The Diltiazem Hydrochloride gives
A.S. Fouda, S.M. Rashwan, M. Kamel, A.A. Badawy   +3 more
doaj   +1 more source