Results 21 to 30 of about 1,803 (117)
Release Characteristics of Diltiazem Hydrochloride Wax-Matrix Granules – Thermal Sintering Effect
Journal of Applied Sciences and Environmental Management, 2011 The aim of this study was to investigate the release characteristics of matrix (non-disintegrating) granules consisting of diltiazem hydrochloride (model drug) and glyceryl behenate (a wax matrix forming polymer) for sustained release application using ...
MU Uhumwangho, RMKV Ramana
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Química Nova, 2011 This work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.8 as the dissolution ...
Taciane Ferreira Mendonça +4 more
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Development of a Halothane-Adrenaline Arrhythmia Model Using In Vivo Guinea Pigs
Journal of Pharmacological Sciences, 2004 In vivo antiarrhythmic effects of diltiazem hydrochloride and nifekalant hydrochloride, a pure class III antiarrhythmic drug (Vaughan Williams’ classification), on adrenaline induced ventricular arrhythmias were examined in halothane anesthetized guinea ...
Yoshiaki Noda, Keitaro Hashimoto
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Psychiatry and Clinical Psychopharmacology, 2021 İn this study we investigated the effects of diltiazem alone or in combination with lithium on some behavioral param eters and serum sodium potassium and calcium levels in rats. 36 W istar Albino rats were divided into 4 groups and treated as follows, C
Göksel Şener +2 more
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Brazilian Journal of Pharmaceutical Sciences, 2011 Diltiazem hydrochloride is a calcium channel blocker generally indicated for the treatment of angina and hypertension, and it is extensively metabolized due to the hepatic metabolism.
Swati Changdeo Jagdale +3 more
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Cellular Physiology and Biochemistry, 2014 Aims: Effect and mechanism of Yulangsan flavonoid (YLSF) on rat myocardial ischemia/reperfusion injury (MI/RI) has been investigated. Methods: Sprague-Dawley (SD) rats were randomly divided into seven groups (sham group, model group and NS group: 2 mL of
Xudong Zhang +9 more
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Formulation and In-Vitro Evaluation of Mucoadhesive Diltiazem Hydrochloride Buccal Tablets
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2011 Mucoadhesive tablets for buccal administration of diltiazem hydrochloride were prepared as an alternative to available diltiazem HCl dosage forms. Two types of tablets were developed each containing two mucoadhesive components (hydroxypropylmethyl ...
Lubna A. Sabri
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Frontiers in Cardiovascular Medicine, 2022 BackgroundThe adverse effects of anticancer therapy in patients with malignancies and cardiovascular diseases are complicated. Oxaliplatin is one of the most commonly used chemotherapy drugs for gastric and colorectal cancers, and oxaliplatin-induced ...
Xi Chen +6 more
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The Journal of Physiology, EarlyView.Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite +9 more
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Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
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