Results 41 to 50 of about 58,398 (178)

Development and validation of a stability indicating HPLC method to determine diltiazem hydrochloride in tablets and compounded capsules

Brazilian Journal of Pharmaceutical Sciences, 2017
A stability indicating HPLC method to determine diltiazem hydrochloride (DTZ) in tablets and compounded capsules was developed and validated according to Brazilian and the International Conference on Harmonization (ICH) guidelines.
Mateus Araújo Castro e Souza, Carlos Eduardo de Oliveira Pereira, Fernando Henrique Andrade Nogueira, Gerson Antônio Pianetti   +3 more
doaj   +1 more source

Coronary arterial spasm detected by coronary computed tomography angiography and confirmed by intravascular ultrasound

Radiology Case Reports, 2018
A 40-year-old man was admitted to our hospital for chest pain after smoking. Coronary computed tomography angiography showed severe stenosis in the left anterior descending artery.
Masafumi Nakayama, MD, Masaharu Hirano, MD, Sonoka Goto, MD, Akifumi Watanabe, MD, Takashi Uchiyama, MD   +4 more
doaj   +1 more source

Development of sustained-release floating tablets of diltiazem hydrochloride

Vietnam Journal of Science, Technology and Engineering
Diltiazem hydrochloride (DTZ), utilised for cardiovascular conditions, possesses a short half-life, necessitating frequent dosing. To enhance compliance, sustainedrelease (SR) floating tablets were developed using a Quality by Design (QbD) approach ...
Hung Pham Van, Tung Nguyen Thanh, Nhat Hoang Thi Anh, Hieu Bui Trung, Uyen Dinh Thi Thu, Duyen Nguyen Thi Thanh   +5 more
doaj   +3 more sources

Aortic Stiffness in L-NAME Treated C57Bl/6 Mice Displays a Shift From Early Endothelial Dysfunction to Late-Term Vascular Smooth Muscle Cell Dysfunction

Frontiers in Physiology, 2022
Introduction and Aims: Endothelial dysfunction is recognized as a cardiovascular aging hallmark. Administration of nitric oxide synthase blocker N-Ω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) constitutes a well-known small animal model of ...
Sofie De Moudt, Jhana O. Hendrickx, Cédric Neutel, Dorien De Munck, Arthur Leloup, Guido R.Y. De Meyer, Wim Martinet, Paul Fransen   +7 more
doaj   +1 more source

Critical insights into analytical methodologies for lidocaine hydrochloride and diltiazem hydrochloride: a comparative review

Future Journal of Pharmaceutical Sciences
Background This study focuses on a fixed-dose combination of lidocaine hydrochloride and diltiazem hydrochloride for the treatment of anal fissures, where lidocaine acts as an anesthetic and diltiazem serves as a slow calcium channel blocker.
Shivani Patel, Archita Patel, Chandni Chandarana, Bhavesh Patel, Mehul Patel, Umang Shah, Swayamprakash Patel, Nilay Solanki, Drashti Shah, Ashish Patel   +9 more
doaj   +1 more source

Poly(ethylene-co-methyl acrylate)/poly(caprolactone) triol blends for drug delivery systems: characterization and drug release

Química Nova, 2012
Poly(ethylene-co-methyl acrylate) (EMA) and poly (caprolactone) triol (PCL-T) blends, a biodegradable aliphatic polyester with low molecular weight and moderate water solubility containing diltiazem hydrochloride (DZ) were studied in terms of the thermal
Luiz A. Kanis, Valdir Soldi
doaj   +1 more source

Formulation Development and Evaluation of Mouth Dissolving Tablets of Diltiazem Hydrochloride by Direct Compression Method [PDF]

, 2018
In some cases of Hypertension Quick onset of action is desired, the Fast dissolving tablets plays a vital role. Fast dissolving tablets have much number of advantages over the conventional tablets like rapid disintegration, faster dissolution, Ease of ...
Saju, R
core  

Bioadhesive drug delivery system of diltiazem hydrochloride for improved bioavailability in cardiac therapy [PDF]

, 2016
Purpose: To prepare and evaluate bioadhesive buccal films of diltiazem  hydrochloride (a L-type calcium channel blocker) for overcoming the limitations of frequent dosing, low bioavailability and gastrointestinal discomfort of oral delivery.Methods ...
Lian, Zhe-Xun, Zhang, Lu, Wei, Wei, Chen, Mei-Na, Wang, Yong-Bin, Zhou, Chang-Yong   +5 more
core   +1 more source

Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride

Acta Pharmaceutica, 2014
Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL).
Yusif Rehab Mohammad, Hashim Irhan Ibrahim Abu, El-Dahan Marwa Salah   +2 more
doaj   +1 more source

Evaluation of the Efficacy and Safety of Diltiazem and Lidocaine Combination Gel in the Treatment of Anal Fissures: A Prospective, Randomized, and Comparative Study

Indian Journal of Colo-Rectal Surgery
Background: Anal fissure is a common and painful anorectal condition affecting across all age groups. Pharmacological management remains the preferred first-line treatment due to its noninvasive nature and effectiveness in reducing pain, sphincter ...
Jaya Maheshwari
doaj   +1 more source