Results 41 to 50 of about 5,295 (204)

Niacin-induced clotting factor synthesis deficiency with coagulopathy [PDF]

, 1992
Although coagulopathy is a well-known complication of severe niacin- induced hepatotoxic reaction, it is not found in patients with minimal aminotransferase level elevations.
Dearing, Brian D., Genton, Edward, Lavie, Carl J., Lohmann, Thomas P.   +3 more
core   +1 more source

A prospective randomized trial of fk506 versus cyclosporine after human pulmonary transplantation [PDF]

, 1994
We have conducted a unique prospective randomized study to compare the effect of PK506 and cyclosporine (CsA) as the principal immunosuppressive agents after pulmonary transplantation.
Armitage, JM, Bando, KO, Fung, JJ, Griffith, BP, Hardesty, RL, Keenan, RJ, Komatsu, K, Konishi, H, Paradis, IL, Pham, SM, Starzl, TE, Yousem, SA   +11 more
core   +1 more source

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

Improved crystal structure solution from powder diffraction data by the use of conformational information [PDF]

, 2017
The effect of introducing conformational information to the DASH implementation of crystal structure determination from powder diffraction data is investigated using 51 crystal structures, with the aim of allowing increasingly complex crystal structures ...
Adrian C. Williams, Allen, Bauer, Bekö, Borea, Bortolotti, Boultif, Bruno, Bruno, Burley, Burley, Bushmarinov, Carpy, Chernyshev, Chernyshev, Cole, David, David, DiMaio, Dinnebier, Donaldson, Dorokhov, Elena A. Kabova, Fernandes, Fernandes, Fernandes, Florence, Florence, Florence, Freer, Gadret, Griffin, Groom, Helmholdt, Ivashevskaya, Jason C. Cole, Johnston, Kennedy, Kenneth Shankland, Kojicprodic, Lefebvre, Llinàs, Maccaroni, Macrae, Majumder, Middleton, Nishibori, Noguchi, Nowell, Oliver Korb, Rukiah, Scapin, Shankland, Shin, Sorrenti, Streek, Yatsenko   +56 more
core   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Hypertension and sudden death disparate effects of calcium entry blocker and diuretic therapy on cardiac dysrhythmias [PDF]

, 1989
This study was designed to evaluate the impact of antihypertensive therapy on cardiac dysrhythmias in 13 hypertensive patients who received calcium entry blockers and in 10 hypertensive patients who received hydrochlorothiazide.
Garavaglia, Guillermo E., Messerli, Franz H., Nunez, Boris D., Nunez, Mireya M., Schmieder, Roland E., Ventura, Hector O.   +5 more
core   +1 more source

Development and validation of a stability indicating HPLC method to determine diltiazem hydrochloride in tablets and compounded capsules

Brazilian Journal of Pharmaceutical Sciences, 2017
A stability indicating HPLC method to determine diltiazem hydrochloride (DTZ) in tablets and compounded capsules was developed and validated according to Brazilian and the International Conference on Harmonization (ICH) guidelines.
Mateus Araújo Castro e Souza, Carlos Eduardo de Oliveira Pereira, Fernando Henrique Andrade Nogueira, Gerson Antônio Pianetti   +3 more
doaj   +1 more source

Landiolol hydrochloride ameliorates acute lung injury in a rat model of early sepsis through the suppression of elevated levels of pulmonary endothelin-1 [PDF]

, 2016
Among the dysfunctions and pathologies associated with sepsis, the underlying molecular mechanisms of sepsis-induced acute lung injury (ALI) are poorly understood.
Akhtar Shila, Hideaki Sakuramoto, Hizawa Nobuyuki, Inoue Yoshiaki, Jesmin Subrina, Kawano Satoru, Khatun Tanzila, Kiwamoto Takumi, Matsuishi Yujiro, Mizutani Taro, Mowa Chishimba Nathan, Shimojo Nobutake, Tsunoda Yoshiya, Zaedi Sohel, 下條 信威, 井上 貴昭, 松石 雄二朗, 檜澤 伸之, 水谷 太郎, 河野 了, 際本 拓未   +20 more
core   +1 more source

Aortic Stiffness in L-NAME Treated C57Bl/6 Mice Displays a Shift From Early Endothelial Dysfunction to Late-Term Vascular Smooth Muscle Cell Dysfunction

Frontiers in Physiology, 2022
Introduction and Aims: Endothelial dysfunction is recognized as a cardiovascular aging hallmark. Administration of nitric oxide synthase blocker N-Ω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) constitutes a well-known small animal model of ...
Sofie De Moudt, Jhana O. Hendrickx, Cédric Neutel, Dorien De Munck, Arthur Leloup, Guido R.Y. De Meyer, Wim Martinet, Paul Fransen   +7 more
doaj   +1 more source

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source