Results 61 to 70 of about 5,295 (204)

Maternal Apocynin During Experimental Preeclampsia Prevents BBB Permeability and Increased Vascular Tone of Cerebral Arteries in Male but Not Female Rat Adult Offspring

open access: yesMicrocirculation, Volume 33, Issue 1, January 2026.
ABSTRACT Objective We examined if exposure to experimental preeclampsia (ePE) impacts vascular permeability and reactivity of posterior cerebral arteries (PCAs) in adult offspring, and if maternal antioxidant treatment prevents these effects in adult male and female offspring. Methods Offspring (F1) from rats with Normal pregnancy (NormPreg_F1), ePE_F1
Milena Esposito   +2 more
wiley   +1 more source

Poly(ethylene-co-methyl acrylate)/poly(caprolactone) triol blends for drug delivery systems: characterization and drug release

open access: yesQuímica Nova, 2012
Poly(ethylene-co-methyl acrylate) (EMA) and poly (caprolactone) triol (PCL-T) blends, a biodegradable aliphatic polyester with low molecular weight and moderate water solubility containing diltiazem hydrochloride (DZ) were studied in terms of the thermal
Luiz A. Kanis, Valdir Soldi
doaj   +1 more source

Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs [PDF]

open access: yes, 2017
Background: Tachycardia-induced remodeling likely plays an important role in atrial fibrillation (AF) maintenance and recurrence after cardioversion, and Ca2+ overload may be an important mediator.
Bénardeau, Agnès   +2 more
core  

The effects of buffer molarity, agitation rate and mesh size on verapamil release from modified release mini-tablets using USP Apparatus 3 [PDF]

open access: yes, 2007
The effects of agitation rate, buffer molarity,and mesh size on the dissolution rate of verapamil hydrochloride from sustained release matrix tablets were studied using USP Apparatus 3.
Khamanga, S M M, Walker, Roderick
core   +2 more sources

Prevalence and Duration of Potential Drug–Drug Interactions Among US Nursing Home Residents, 2018–2020

open access: yesJournal of the American Geriatrics Society, Volume 73, Issue 12, Page 3766-3777, December 2025.
ABSTRACT Background Nursing home (NH) residents are at increased risk of drug–drug interactions (DDIs) due to multimorbidity and polypharmacy. While prior research suggests that many DDIs lead to adverse drug events in older adults, the extent of exposure to potentially clinically relevant DDIs among United States (US) NH residents is largely unknown ...
Laura A. Reich   +9 more
wiley   +1 more source

Comparative study on the rheological properties and tablettability of various APIs and their composites with titanate nanotubes [PDF]

open access: yes, 2017
The present study aimed to investigate the processability of API-titanate nanotube composites into direct compressed tablets and therefore to reveal the benefits of the composite formation provided in tablet manufacturing.
Hódi Klára   +4 more
core   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

open access: yesAdvanced Functional Materials, Volume 35, Issue 35, August 28, 2025.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan   +4 more
wiley   +1 more source

CARDIOVASCULAR EFFECTS OF DILTIAZEM IN THE DOG [PDF]

open access: yes, 2017
SUMMARY The effects of two bolus injections (0.2 mg kg−1) and two infusion rates (0.2 mg min−1 and 0.4 mg min−1) ofdiltiazem on global and regional left (LV) and right ventricular (RV) performance (ultrasonic dimension technique), on coronary ...
PRIEBE, H.-J, SKARVAN, K.
core  

Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori [PDF]

open access: yes, 2015
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection.
Adebisi   +59 more
core   +1 more source

Litigating the Drug Price Competition and Patent Term Restoration Act of 1984 [PDF]

open access: yes, 2012
The Drug Price Competition and Patent Term Restoration Act of 1984, also known as the Hatch-Waxman Act in honor of its sponsors Senator Orrin Hatch and Representative Henry Waxman, was enacted in an attempt to reconcile two seemingly contradictory policy
Reines, Emily B.
core  

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