Results 61 to 70 of about 5,295 (204)
ABSTRACT Objective We examined if exposure to experimental preeclampsia (ePE) impacts vascular permeability and reactivity of posterior cerebral arteries (PCAs) in adult offspring, and if maternal antioxidant treatment prevents these effects in adult male and female offspring. Methods Offspring (F1) from rats with Normal pregnancy (NormPreg_F1), ePE_F1
Milena Esposito +2 more
wiley +1 more source
Poly(ethylene-co-methyl acrylate) (EMA) and poly (caprolactone) triol (PCL-T) blends, a biodegradable aliphatic polyester with low molecular weight and moderate water solubility containing diltiazem hydrochloride (DZ) were studied in terms of the thermal
Luiz A. Kanis, Valdir Soldi
doaj +1 more source
Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs [PDF]
Background: Tachycardia-induced remodeling likely plays an important role in atrial fibrillation (AF) maintenance and recurrence after cardioversion, and Ca2+ overload may be an important mediator.
Bénardeau, Agnès +2 more
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The effects of buffer molarity, agitation rate and mesh size on verapamil release from modified release mini-tablets using USP Apparatus 3 [PDF]
The effects of agitation rate, buffer molarity,and mesh size on the dissolution rate of verapamil hydrochloride from sustained release matrix tablets were studied using USP Apparatus 3.
Khamanga, S M M, Walker, Roderick
core +2 more sources
ABSTRACT Background Nursing home (NH) residents are at increased risk of drug–drug interactions (DDIs) due to multimorbidity and polypharmacy. While prior research suggests that many DDIs lead to adverse drug events in older adults, the extent of exposure to potentially clinically relevant DDIs among United States (US) NH residents is largely unknown ...
Laura A. Reich +9 more
wiley +1 more source
Comparative study on the rheological properties and tablettability of various APIs and their composites with titanate nanotubes [PDF]
The present study aimed to investigate the processability of API-titanate nanotube composites into direct compressed tablets and therefore to reveal the benefits of the composite formation provided in tablet manufacturing.
Hódi Klára +4 more
core +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
CARDIOVASCULAR EFFECTS OF DILTIAZEM IN THE DOG [PDF]
SUMMARY The effects of two bolus injections (0.2 mg kg−1) and two infusion rates (0.2 mg min−1 and 0.4 mg min−1) ofdiltiazem on global and regional left (LV) and right ventricular (RV) performance (ultrasonic dimension technique), on coronary ...
PRIEBE, H.-J, SKARVAN, K.
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Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori [PDF]
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection.
Adebisi +59 more
core +1 more source
Litigating the Drug Price Competition and Patent Term Restoration Act of 1984 [PDF]
The Drug Price Competition and Patent Term Restoration Act of 1984, also known as the Hatch-Waxman Act in honor of its sponsors Senator Orrin Hatch and Representative Henry Waxman, was enacted in an attempt to reconcile two seemingly contradictory policy
Reines, Emily B.
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