Results 61 to 70 of about 5,306 (202)

A Simple and Rapid Analytical Method to Detect and Quantify the N‐Nitroso Desmethyl Diltiazem Impurity by Liquid Chromatography‐Tandem Mass Spectrometry in Diltiazem Hydrochloride

SEPARATION SCIENCE PLUS, Volume 8, Issue 5, May 2025.
ABSTRACT N‐nitroso desmethyl diltiazem is a known genotoxic impurity in the cardiovascular drug product diltiazem hydrochloride, raising significant concerns due to its potential carcinogenicity. Detection of such impurities at trace levels is crucial to ensure drug safety and regulatory compliance.
Manoj Kumar Mandapaka, Veeraswami Boddu
wiley   +1 more source

One of These Things Is Not Quite the Same: A Comparison of the Patent Doctrine of Equivalents with Suitability for Filing an Abbreviated New Drug Application [PDF]

, 2012
The doctrine of equivalents as applied to chemical patents is compared to the FDA’s findings of bioequivalence in reviewing suitability petitions for filing Abbreviated New Drug Applications (ANDAs).
Halstead, David P.
core  

Increase in systolic blood pressure during exercise testing after heart transplantation: correlation with the clinical condition and ventricular function assessed by dobutamine stress echocardiography [PDF]

, 2006
OBJECTIVE: Patients who underwent heart transplantation (HTX) experience a reduction in the elevation that is usual in systolic blood pressure during exercise testing. Of unknown origin, this phenomenon varies in frequency and intensity.
Almeida, Dirceu Rodrigues de, Carvalho, Antonio Carlos, Cordovil, Adriana, Leite, Wagner Aparecido, Machado, Cristiano Vieira, Moisés, Valdir Ambrósio, Oliveira Filho, Japy Angelini, Salles, Ana Fátima   +7 more
core   +4 more sources

Poly(ethylene-co-methyl acrylate)/poly(caprolactone) triol blends for drug delivery systems: characterization and drug release

Química Nova, 2012
Poly(ethylene-co-methyl acrylate) (EMA) and poly (caprolactone) triol (PCL-T) blends, a biodegradable aliphatic polyester with low molecular weight and moderate water solubility containing diltiazem hydrochloride (DZ) were studied in terms of the thermal
Luiz A. Kanis, Valdir Soldi
doaj   +1 more source

CARDIOVASCULAR EFFECTS OF DILTIAZEM IN THE DOG [PDF]

, 2017
SUMMARY The effects of two bolus injections (0.2 mg kg−1) and two infusion rates (0.2 mg min−1 and 0.4 mg min−1) ofdiltiazem on global and regional left (LV) and right ventricular (RV) performance (ultrasonic dimension technique), on coronary ...
PRIEBE, H.-J, SKARVAN, K.
core  

An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK [PDF]

, 2016
Background: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use.
Andreasson, Andreasson, Anyanwu, Arcasoy, Avlonitis, Avlonitis, Behrendt, Benden, Bjørk, Boffini, Boffini, Botha, Brazier, Briggs, Brown, Bury, Charmaz, Christie, Couraud, Curtis, Cypel, Cypel, Cypel, Cypel, Cypel, Cypel, De Perrot, Department of Health, Entwistle, Fielding, Fischer, Fisher, Fisher, Fisher, Fisher, Fisher, Fisher, Gibbs, Glaser, Great Britain, Haugh, Henriksen, Information Services Division, Ingemansson, International Society for Heart and Lung Transplantation, ISD Scotland, Itano, Jirsch, Joint Formulary Committee, Kaba, Kaneda, Kierans, Korovesi, Krutsinger, Lee, Littlefield, Long, Lowton, Lowton, Machuca, Martins, Mays, Moran, Naef, National Health Service, National Heart Lung and Blood Institute, National Institute for Health and Care Excellence, National Institute for Health Care Excellence, NHS Blood and Transplant, NHS Blood and Transplant, NHS Business Service Authority, Office for National Statistics, Okada, OPTUM, Orens, O’Grady, RAND Health, RAND Health Corporation, Renshaw, Roberts, Royal College of Surgeons, Sage, Sanchez, Sanchez, Schaeffer, Siebert, Steen, Steen, Taylor, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Tikkanen, TransMedics, TransMedics, UK Government Department of Constitutional Affairs, van Enckevort, Wallinder, Ware, Warnecke, Warnecke, Wierup, World Medical Organization, XVIVO Perfusion, Zych   +102 more
core   +4 more sources

Part 2: Drug Interactions Involving Cannabis Products in Persons Aged 18 and Over: A Summary of Published Case Reports and Analysis of the FDA Adverse Event Reporting System

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
ABSTRACT The increasing utilization of cannabis products combined with lack of data regarding potential cannabis–prescription drug interactions is concerning. This study aimed to review published case reports and FDA Adverse Event Reporting System (FAERS) spontaneous reports to assess cannabis–drug interactions in persons aged 18 and over. A literature
Maryann R. Chapin, Sandra L. Kane‐Gill, Xiaotong Li, Kojo Abanyie, Sanya B. Taneja, Susan Egbert, Mary F. Paine, Richard D. Boyce   +7 more
wiley   +1 more source

Litigating the Drug Price Competition and Patent Term Restoration Act of 1984 [PDF]

, 2012
The Drug Price Competition and Patent Term Restoration Act of 1984, also known as the Hatch-Waxman Act in honor of its sponsors Senator Orrin Hatch and Representative Henry Waxman, was enacted in an attempt to reconcile two seemingly contradictory policy
Reines, Emily B.
core  

Differential behavioral state-dependence in the burst properties of CA3 and CA1 neurons [PDF]

, 2006
Brief bursts of fast high-frequency action potentials are a signature characteristic of CA3 and CA1 pyramidal neurons. Understanding the factors determining burst and single spiking is potentially significant for sensory representation, synaptic ...
Chrobak, J. J., Markus, E. J., Oler, J. A., Quirk, M. C., Tropp Sneider, J.   +4 more
core   +1 more source

Association between chronic diseases and severe periodontal disease progression: A retrospective cohort study in a city of Japan

Journal of General and Family Medicine, Volume 26, Issue 1, Page 54-64, January 2025.
This manuscript is a study demonstrating the association between the progression of severe periodontal diseases and chronic diseases commonly addressed in primary care. We used claims data and defined the outcome as the “progression of severe periodontitis” and followed patients for 4 years.
Sayaka Nin, Yu Sun, Takami Maeno, Chihiro Nishiura, Kento Taira, Kenji Fujimoto, Jun Hamano, Sachiko Ozone, Tetsuhiro Maeno   +8 more
wiley   +1 more source