Results 81 to 90 of about 5,306 (202)

Patterns of antihypertensive prescribing, discontinuation and switching among a Hong Kong Chinese population from over one million prescriptions [PDF]

, 2008
Hypertension is an alarming public health problem among Chinese. The present study evaluated the prescribing patterns, discontinuation and switching profiles of antihypertensive agents and their associated factors in one Hong Kong Chinese population ...
A Fretheim, A T Lam, BM Cheung, G Onder, H Fung, H Mori, J Ma, J Y Jiang, M C S Wong, MCS Wong, S Griffiths, S W Mercer, T Walley, YH Yuen, Z Kabir   +14 more
core   +1 more source

Evaluation of the drug–drug interaction potential of brigatinib using a physiologically‐based pharmacokinetic modeling approach

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 4, Page 624-637, April 2024.
Abstract Brigatinib is an oral anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment of ALK‐positive metastatic non‐small cell lung cancer. In vitro studies indicated that brigatinib is primarily metabolized by CYP2C8 and CYP3A4 and inhibits P‐gp, BCRP, OCT1, MATE1, and MATE2K.
Michael J. Hanley, Karen Rowland Yeo, Meera Tugnait, Shinji Iwasaki, Narayana Narasimhan, Pingkuan Zhang, Karthik Venkatakrishnan, Neeraj Gupta   +7 more
wiley   +1 more source

Effects of simulated weightlessness on regional blood flow specifically during cardiovascular stress [PDF]

Significant changes in the cardiovasular system of humans and animals have been observed following exposure to prolonged periods of weightlessness during space flight.
Harrison, D. C.
core   +1 more source

Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori [PDF]

, 2015
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection.
Adebisi, Adebisi, Adeola O. Adebisi, Ahuja, Akiyama, Bai, Bajpai, Barbara R. Conway, Batchelor, Bazzoli, Boddupalli, Cammarota, Castro, Chun, Desai, Dunn, Dupuy, Erah, Erah, Ernst, Gal, Georgopoulos, Gåserød, Higuchi, Hixson, Iijima, Ikeda, Ishak, Kawahara, Khanvilkar, Kohri, Korsmeyer, Lee, Lehmann, Malfertheiner, Miyazaki, Moore, Murata, Murray, Najib, Nakagawa, Nayak, Norris, Park, Pasparakis, Pereira, Peter R. Laity, Peterson, Rajinikanth, Romero, Rothenbacher, Singh, Smrdel, Stops, Suerbaum, Suzuki, Umamaheshwari, Varum, Whitehead, Østberg   +59 more
core   +1 more source

Health services research in the public healthcare system in Hong Kong: An analysis of over 1 million antihypertensive prescriptions between 2004-2007 as an example of the potential and pitfalls of using routinely collected electronic patient data [PDF]

, 2008
<b>Objectives</b> Increasing use is being made of routinely collected electronic patient data in health services research. The aim of the present study was to evaluate the potential usefulness of a comprehensive database used routinely in the
A McCormack, AL Nightingale, Augustine Lam, AW Hoes, DM Fleming, EE Degli, EPIC, F Trevisani, G Edgren, G Mazzaglia, GC Smith, GL Booth, H Ueshima, Hong Fung, I Nazareth, I Nazareth, InterASIA Collaborative group, J Hollowell, JA Cassell, JB Soriano, JE Hux, JI Williams, Jin-ling Tang, JK Jones, Johnny Y Jiang, JR Hardy, K Tu, KM Madsen, M Ezzati, Martin CS Wong, PM Kearney, R Gupta, R Jones, R Lawrenson, R Lawrenson, RB Singh, RB Singh, RG Gibbs, RJ Cruz-Correia, S Capewell, SS Soedamah-Muthu, Stewart W Mercer, T Karopka, T Walley, TA Burke, TM McKeever, TR Mikuls, TR Mikuls   +47 more
core   +4 more sources

Evaluation of gum mastic (Pistacia lentiscus) as a microencapsulating and matrix forming material for sustained drug release

Asian Journal of Pharmaceutical Sciences, 2017
In this study, a natural gum mastic was evaluated as a microencapsulating and matrix-forming material for sustained drug release. Mastic was characterized for its physicochemical properties.
Dinesh M. Morkhade
doaj   +1 more source

Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs [PDF]

, 2017
Background: Atrial tachycardia-induced remodeling promotes the occurrence and maintenance of atrial fibrillation (AF) and decreases L-type Ca2+ current. There is also a clinical suggestion that acute L-type Ca2 channel blockade can promote AF, consistent
Bénardeau, Agnès, Fareh, Samir, Nattel, Stanley   +2 more
core  

Herbal carrier-based floating microparticles of diltiazem hydrochloride for improved cardiac activity [PDF]

, 2017
Purpose: To formulate and characterize a gastroretentive floating drug delivery system for diltiazem hydrochloride using psyllium husk and sodium alginate as natural herbal carriers to improve the therapeutic effect of the drug in cardiac patients ...
Ren, Hong-Qiang, Yuan, Bai-Jing, Yuan, Jin-qi, Zhang, Min-Li, Zhao, Li, Zhao, Xin-Fang, Zhou, Yun   +6 more
core   +2 more sources

Formulation and Evaluation of Chitosan-Gellan Beads as Controlled Drug Delivery System of Antihypertensive Drug

Journal of Basic and Applied Research in Biomedicine, 2022
The use of natural polymers in the design of drug delivery formulation has received much attention due to their excellent biocompatibility and biodegradability.
Rohit Bhosale, Riyaz Ali Osmani, H Gangadharappa   +2 more
doaj   +2 more sources

Permeability studies of Damar Batu free films for transdermal application [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2009
Damar Batu (DB) looks like stone with black or dark brown color inside. Due to its film forming ability it is used in the manufacture of paper, wood, varnishes, lacquers, polishes and additives for beverages. In the present study the permeability of free
ATISH S. MUNDADA, JASMINE G. AVARI
doaj