A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties [PDF]
, 2015 INTRODUCTION: Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis.
Gregory R. J. Thatcher +5 more
core +1 more source
Dimethyl Fumarate Attenuates Methotrexate Hepatotoxicity in Mice Via the Nrf2/HO-1/Anti-Apoptotic Signaling Pathway [PDF]
, 2023 Mohammad Ali Karimi +5 more
openalex +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common non‐Hodgkin lymphoma and is an aggressive and highly heterogeneous tumor. Kaempferitrin (KPF) is a natural flavonoid glycoside that exerts a protective role in multiple human tumors. However, the impact of KPF on DLBCL remains unclear.
Han‐Shuo Zhang +3 more
wiley +1 more source
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases [PDF]
, 2019 The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), are critical in the maintenance of redox, metabolic and protein ...
Attucks, Otis C. +10 more
core +2 more sources
The Journal of Pathology, EarlyView.Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou +3 more
wiley +1 more source
New insights in the targets of action of dimethyl fumarate in endothelial cells: effects on energetic metabolism and serine synthesis [PDF]
, 2022 Ma Carmen Ocaña +8 more
openalex +1 more source
Protective Role for Itaconate During Inhaled Allergen Challenge
Allergy, EarlyView.Itaconate levels decrease in sputum following allergen inhalation in mild asthmatics, suggesting a dynamic metabolic response to airway challenge. Genetic deletion of Acod1 in mice did not alter airway inflammation or remodelling in response to chronic HDM exposure.
Gesa J. Albers +16 more
wiley +1 more source
The FEBS Journal, EarlyView.A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner +17 more
wiley +1 more source
Desulfovibrio paquesii sp. nov., a hydrogenotrophic sulfate-reducing bacterium isolated from a synthesis-gas-fed bioreactor treating zinc- and sulfate-rich wastewater [PDF]
, 2009 A hydrogenotrophic, sulfate-reducing bacterium, designated strain SB1(T), was isolated from sulfidogenic sludge of a full-scale synthesis-gas-fed bioreactor used to remediate wastewater from a zinc smelter. Strain SB1(T) was found to be an abundant micro-
Doesburg, W., van +5 more
core +2 more sources
Evaluation of the effect of dimethyl fumarate on human bone marrow-derived mesenchymal stem cells using bottom-up proteomics [PDF]
, 2023 Maryam Adelipour +6 more
openalex +1 more source