Results 61 to 70 of about 28,189 (202)

Multi-heme Cytochromes in Shewanella oneidensis MR-1:Structures, functions and opportunities [PDF]

, 2015
Multi-heme cytochromes are employed by a range of microorganisms to transport electrons over distances of up to tens of nanometers. Perhaps the most spectacular utilization of these proteins is in the reduction of extracellular solid substrates ...
Brown JP, Collins MJ, Coursolle D, Fonseca BM, Jochen Blumberger, Julea N. Butt, Kevin M. Rosso, Marian Breuer, Song Y, Teixeira M   +9 more
core   +1 more source

Block Copolymers: Emerging Building Blocks for Additive Manufacturing

Advanced Functional Materials, EarlyView.
This review addresses how block copolymer (BCP) physics and rheology have led to the widespread use of BCPs in advanced additive manufacturing techniques, with particular emphasis on the untapped potential of these nanostructured materials toward achieving multi‐scale architected materials with unique, programmable material properties.
Alice S. Fergerson, Hemish B. Thakkar, Jiaen Wu, Emily C. Davidson   +3 more
wiley   +1 more source

Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro

Journal of Pharmacological Sciences, 2018
Chemotherapy agents such as oxaliplatin, cisplatin, paclitaxel, and bortezomib frequently cause severe peripheral neuropathy and there is currently no effective strategy to prevent this.
Takehiro Kawashiri, Anna Miyagi, Shiori Shimizu, Nao Shigematsu, Daisuke Kobayashi, Takao Shimazoe   +5 more
doaj   +1 more source

Cascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition. [PDF]

, 2016
Simple haloaldehydes, including enolisable aldehydes, were found to be suitable for the formation of cyclic products by cascade (domino) condensation, cyclisation, dipolar cycloaddition chemistry.
Aasen, Ali, Ali, Burdisso, Burdisso, Burrell, Burrell, Burrell, Burrell, Coldham, Coldham, Coldham, Coldham, Coldham, Coldham, Davison, Denmark, Deno, Flick, Grashey, Grigg, Ha, Harry Adams, Heather E. Holberry, Huisgen, Hélène D. S. Guerrand, Iain Coldham, Ito, Jonathan R. Shewring, Laemmerhold, LeBel, Ma, Mulzer, Page, Pandey, Peng, Rachel C. Furnival, Revuelta, Rungroj Saruengkhanphasit, Rüeger, Sarkar, Sengoku, Shono, Siriwardena, Stockman, Suneel Kumar, Tufariello, Wilson, Yamato   +48 more
core   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Incidence of type 2 diabetes, cardiovascular disease and chronic kidney disease in patients with multiple sclerosis initiating disease-modifying therapies: Retrospective cohort study using a frequentist model averaging statistical framework.

PLoS ONE
Researchers are increasingly using insights derived from large-scale, electronic healthcare data to inform drug development and provide human validation of novel treatment pathways and aid in drug repurposing/repositioning.
Alan J M Brnabic, Sarah E Curtis, Joseph A Johnston, Albert Lo, Anthony J Zagar, Ilya Lipkovich, Zbigniew Kadziola, Megan H Murray, Timothy Ryan   +8 more
doaj   +1 more source

Alopecia in Multiple Sclerosis Patients Treated with Disease Modifying Therapies

Journal of Central Nervous System Disease, 2022
BACKGROUND There is currently limited literature addressing the reporting of alopecia in multiple sclerosis (MS) patients treated with disease-modifying therapies (DMTs).
Mokshal H. Porwal, Amber Salter, Dhruvkumar Patel, Ahmed Z. Obeidat   +3 more
doaj   +1 more source

Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure

iScience, 2021
Summary: Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In this
Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay   +17 more
doaj   +1 more source

Relapsing-remitting multiple sclerosis: advances in disease-modifying therapies [PDF]

, 2015
Multiple sclerosis is a demyelinating disease affecting the central nervous system. It is the most prevalent disabling neurological condition among young adults, with onset typically between 20 and 40 years of age. Infiltrating immune cells and microglia
Kay, Kathleen Alexandra
core   +1 more source

Post-polymerisation modification of bio-derived unsaturated polyester resins via Michael additions of 1,3-dicarbonyls [PDF]

, 2016
Post-polymerisation modification of α,β-unsaturated polyesters (UPEs) is useful to deliver polymers with tuneable properties and applications different from their parent backbone.
Castle, R. L., Clark, J. H., Farmer, T. J., Macquarrie, D. J., Ogunjobi, J. K.   +4 more
core   +1 more source