Results 61 to 70 of about 30,023 (217)

Alopecia in Multiple Sclerosis Patients Treated with Disease Modifying Therapies

Journal of Central Nervous System Disease, 2022
BACKGROUND There is currently limited literature addressing the reporting of alopecia in multiple sclerosis (MS) patients treated with disease-modifying therapies (DMTs).
Mokshal H. Porwal, Amber Salter, Dhruvkumar Patel, Ahmed Z. Obeidat   +3 more
doaj   +1 more source

Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis [PDF]

, 2015
Different therapeutic strategies are available for the treatment of people with relapsing-remitting multiple sclerosis (RRMS), including immunomodulators, immunosuppressants and biologics.
D'Amico, Roberto, Del Giovane, Cinzia, Filippini, Graziella, Salanti, Georgia, Tramacere, Irene   +4 more
core   +1 more source

Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress [PDF]

, 2021
Kejun Zhou, Mengyi Xie, Shuli Yi, Yun Tang, Haojun Luo, Qiong Xiao, Jun Xiao, Yi Li   +7 more
openalex   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Incidence of type 2 diabetes, cardiovascular disease and chronic kidney disease in patients with multiple sclerosis initiating disease-modifying therapies: Retrospective cohort study using a frequentist model averaging statistical framework.

PLoS ONE
Researchers are increasingly using insights derived from large-scale, electronic healthcare data to inform drug development and provide human validation of novel treatment pathways and aid in drug repurposing/repositioning.
Alan J M Brnabic, Sarah E Curtis, Joseph A Johnston, Albert Lo, Anthony J Zagar, Ilya Lipkovich, Zbigniew Kadziola, Megan H Murray, Timothy Ryan   +8 more
doaj   +1 more source

Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure

iScience, 2021
Summary: Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In this
Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay   +17 more
doaj   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Mononuclear cell transcriptome changes associated with dimethyl fumarate in MS. [PDF]

, 2018
ObjectiveTo identify short-term changes in gene expression in peripheral blood mononuclear cells (PBMCs) associated with treatment response to dimethyl fumarate (DMF, Tecfidera) in patients with relapsing-remitting MS (RRMS).MethodsBlood samples were ...
Baranzini, Sergio E, Cencioni, Maria T, Gafson, Arie R, Kim, Kicheol, Matthews, Paul M, Nicholas, Richard, van Hecke, Wim   +6 more
core  

Post-polymerisation modification of bio-derived unsaturated polyester resins via Michael additions of 1,3-dicarbonyls [PDF]

, 2016
Post-polymerisation modification of α,β-unsaturated polyesters (UPEs) is useful to deliver polymers with tuneable properties and applications different from their parent backbone.
Castle, R. L., Clark, J. H., Farmer, T. J., Macquarrie, D. J., Ogunjobi, J. K.   +4 more
core   +1 more source

Dimethyl fumarate-related immune and transcriptional signature is associated with clinical response in multiple sclerosis-treated patients [PDF]

, 2023
Alicia Sánchez-Sanz, Santiago García‐Martín, Julia Sabín-Muñoz, Irene Moreno‐Torres, V́ıctor Elvira, Fátima Al‐Shahrour, Aránzazu García‐Grande, Elvira Ramil, Ofir Rodríguez-De la Fuente, Beatriz Brea-Álvarez, Ruth García-Hernández, Antonio Garcı́a-Merino, Antonio Sánchez   +12 more
openalex   +1 more source