Results 81 to 90 of about 28,189 (202)

Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation

EJNMMI Research, 2022
Highlights In a focal rat DTH-EAE model of neuroinflammation, dimethyl fumarate decreases the uptake of TSPO PET tracer [18F]GE-180 in the short term. Long-term [18F]GE-180 follow-up did not indicate a treatment effect.
S. K. Vainio, A. M. Dickens, M. Matilainen, F. R. López-Picón, R. Aarnio, O. Eskola, O. Solin, D. C. Anthony, J. O. Rinne, L. Airas, M. Haaparanta-Solin   +10 more
doaj   +1 more source

Breaking the cycle: reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate [PDF]

, 2019
Objective To infer molecular effectors of therapeutic effects and adverse events for dimethyl fumarate (DMF) in relapsing-remitting MS patients (RRMS) using untargeted plasma metabolomics.
David, M. J., Gafson, A. R., Gomez-Romero, M., Heslegrave, A., Lewis, M. R., Matthews, P. M., Nicholas, R., Nicholson, J., Savva, C., Thorne, Tom, Zetterberg, H.   +10 more
core   +3 more sources

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro.

PLoS ONE, 2015
Delayed-release dimethyl fumarate (also known as gastro-resistant dimethyl fumarate), an oral therapeutic containing dimethyl fumarate (DMF) as the active ingredient, is currently approved for the treatment of relapsing multiple sclerosis.
Melanie S Brennan, Maria F Matos, Bing Li, Xiaoping Hronowski, Benbo Gao, Peter Juhasz, Kenneth J Rhodes, Robert H Scannevin   +7 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Phase 1 study of balinatunfib, an oral inhibitor of TNFR1 signal in mild‐to‐moderate psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Balinatunfib is the first oral, small molecule selective inhibitor of TNFR1 signaling. The results of this study indicate that balinatunfib treatment was tolerable with no serious or severe adverse events in patients with mild‐to‐moderate psoriasis and showed clinical responses.
Nassr Nassr, Ohn A. Chow, Mai Anh Nguyen, Laurent Perrin, Fabienne Schumacher, Frank‐Dietrich Wagner, Caroline Dreis, Amel Lahmar, Markus Kohlmann, Maria Wiekowski, Tiago R. Matos   +10 more
wiley   +1 more source

A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties [PDF]

, 2015
INTRODUCTION: Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis.
Gregory R. J. Thatcher, Irida Kastrati, Jonna Frasor, Manuel Alvarez, Shuangping Zhao, Vladislav A. Litosh   +5 more
core   +1 more source

Mitochondrial β‐carbonic anhydrase is a conserved metabolic rheostat for branched‐chain amino acid catabolism and metabolic flexibility

New Phytologist, EarlyView.
Summary Carbonic anhydrases (CAs) are ubiquitous metalloenzymes that catalyze the reversible hydration of CO2, enabling fundamental processes in organisms across all domains of life. Among all CAs, the role of mitochondrial βCA remains poorly understood. Here, we identify a mitochondrial βCA, βCA6, as a key regulator of branched‐chain amino acid (BCAA)
Naveen Sharma, Thomas D. Sharkey, Federica Brandizzi   +2 more
wiley   +1 more source

Advancement in Anaerobic Digestion for Scaling‐Up Biogas Production Through Food Waste Valorization

ChemBioEng Reviews, Volume 13, Issue 2, April 2026.
The review article begins with an introduction that covers the overview, food waste (FW) classification, and the steps involved in producing biogas through anaerobic digestion (AD). Following that, it describes the process for producing biogas, including single‐, two‐, and multistage systems, mesophilic and thermophilic digestion, and wet and dry ...
Poulami Chatterjee, Nabanita Saha, Petr Sáha   +2 more
wiley   +1 more source

Differential effects of disease modifying drugs on peripheral blood B cell subsets: A cross sectional study in multiple sclerosis patients treated with interferon-β, glatiramer acetate, dimethyl fumarate, fingolimod or natalizumab.

PLoS ONE, 2020
BackgroundSeveral disease modifying drugs (DMDs) have been approved for the treatment of multiple sclerosis (MS), however, little is known about their differential impact on peripheral blood (PB) B cell subsets.MethodsWe performed a cross sectional study
C L Kemmerer, V Pernpeintner, C Ruschil, A Abdelhak, M Scholl, U Ziemann, M Krumbholz, B Hemmer, M C Kowarik   +8 more
doaj   +1 more source