Results 41 to 50 of about 386,611 (320)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

[1,2-Bis(diphenylphosphanyl)ethane-κ2P,P′]dichloridopalladium(II) dimethyl sulfoxide monosolvate

Acta Crystallographica Section E, 2012
In the title compound, [PdCl2(C26H24P2)]·C2H6OS, the PdII atom adopts a distorted cis-PdCl2P2 square-planar coordination geometry. The five-membered chelate ring adopts an envelope conformation with a methylene C atom in the flap position. The S
Ismail Warad, Abdullah S. Aldwayyan, Fahad M. Al-Jekhedab, M. Iqbal Choudhary, Sammer Yousuf   +4 more
doaj   +1 more source

Crystal structure of 4-chloro-<i>N</i>-{5-(4-meth-oxyphen-yl)-4-[(4-meth-oxy-phen-yl)amino]-6-sulfanyl-idene-1,2,5,6-tetra-hydro-1,3,5-triazin-2-yl-idene}benzene-sulfonamide dimethyl sulfoxide disolvate. [PDF]

Acta Crystallogr E Crystallogr Commun
Mohamed-Ezzat RA, Elgemeie GH, Jones PG.
europepmc   +3 more sources

Ambidentate coordination in hydrogen bonded dimethyl sulfoxide, (CH3)2SOH3O+, and in dichlorobis(dimethyl sulfoxide) palladium(II) and platinum(II) solid solvates, by vibrational and sulfur K-edge X-ray absorption spectroscopy [PDF]

, 2009
The strongly hydrogen bonded species (CH3)(2)SO center dot center dot center dot H3O+ formed in concentrated hydrochloric acid displays a new low energy feature in its sulfur K-edge X-ray absorption near edge structure (XANES) spectrum.
Abbasi, Alessio, Alessio, Alireza Abbasi, Bennett, Calligaris, Damian, Damian Risberg, Damian Risberg, Davies, Degen, Emiliana Damian Risberg, Goggin, Jaswal, Johnson, János Mink, Konovalov, Küchle, Laszló Hajba, Magnus Sandström, Mikhail Yu. Skripkin, Mink, Molla-Abbassi, Ohba, Patric Lindqvist-Reis, Pelissier, Shibaeva, Skripkin, Takazawa, Taylor, Tranquille, Tranquille, Éva Bencze   +32 more
core   +1 more source

Platelet Biochemistry and Morphology after Cryopreservation [PDF]

, 2020
Platelet cryopreservation has been investigated for several decades as an alternative to room temperature storage of platelet concentrates. The use of dimethylsulfoxide as a cryoprotectant has improved platelet storage and cryopreserved concentrates can ...
Compernolle, Veerle, Feys, Hendrik, Six, Katrijn   +2 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

trans-Bis(3-hydroxypyridine-&#954;N)diiodidoplatinum(II) dimethyl sulfoxide disolvate

Acta Crystallographica Section E, 2011
In the title compound, [PtI2(C5H5NO)2]&#183;2(CH3)2SO, the PtII ion lies on an inversion center and is coordinated in a slightly distorted square-planar environment by two trans iodide ligands and two pyridine N atoms.
Fazlul Huq, Muhammed Danish, Wojciech Starosta, Janusz Leciejewicz   +3 more
doaj   +1 more source

AFM study of oxygen reduction products on HOPG in the LiPF6–DMSO electrolyte [PDF]

, 2013
Ex situ atomic force microscopy (AFM) has been used to study the morphology of oxygen reduction products in the LiPF6–dimethyl sulfoxide (DMSO) electrolyte, i.e. Li2O2 on a highly oriented pyrolytic graphite (HOPG) surface.
Calvo, Ernesto Julio, Clarenc, Romain, Herrera, Santiago Esteban, Tesio, Alvaro Yamil   +3 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Dichlorido{N-[2-(diphenylphosphanyl)benzylidene]isopropylamine-&#954;2N,P}palladium(II) dimethyl sulfoxide monosolvate

Acta Crystallographica Section E, 2011
In the title PdII complex, [PdCl2(C22H22NP)]&#183;(CH3)2SO, the PdII atom is coordinated in an NPCl2 coordination sphere by the N(imino) and P(phosphane) atoms of the ligand and by two Cl&#8722; ions in a slightly distorted square-planar geometry
Haleden Chiririwa, Reinout Meijboom, Bernard Omondi   +2 more
doaj   +1 more source