Results 41 to 50 of about 556,826 (407)

Electrochemical synthesis of methyl sulfoxides from thiophenols/thiols and dimethyl sulfoxide

, 2018
A new route for a one-pot synthesis of methyl sulfoxides from thiophenols/thiols and dimethyl sulfoxide using an electrochemical technique was developed. This protocol proceeded smoothly by employing electrons and hydrogen peroxide as clean oxidants, and
Ke-Si Du, Jing‐Mei Huang
semanticscholar   +1 more source

The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study

Theranostics, 2017
Rationale: Dimethyl sulfoxide (DMSO) is commonly used as a solvent for water-insoluble substances, a vehicle for drug therapy, and a cryoprotectant for cultured cells. DMSO induced embryonic defects and its mechanism of action remains unclear.
M. Kang, J. Das, Sangiliyandi Gurunathan, Hwan-Woo Park, Hyuk Song, Chankyu Park, Jin-Hoi Kim   +6 more
semanticscholar   +1 more source

Bis[4-hydroxy-N′-(4-methoxy-2-oxidobenzylidene-κO2)benzohydrazidato-κ2O,N′]cadmium(II) dimethyl sulfoxide disolvate

Acta Crystallographica Section E, 2009
The metal atom in the title compound, [Cd(C15H13N2O4)2]·2C2H6OS, is twice O,N,O′-chelated by two symmetry-related Schiff base ligands to define a trans-N2O4 octahedral geometry.
Nooraziah Mohd Lair, Seik Weng Ng, Hapipah Mohd Ali   +2 more
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

9-(5-Bromo-1H-indol-3-yl)-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione dimethyl sulfoxide monosolvate

Acta Crystallographica Section E, 2012
In the title compound, C21H19BrN2O2·C2H6OS, the indole ring system is essentially planar, with a maximum deviation of 0.050 (3) Å for the non-bridgehead C atom adjacent to the N atom.
Ahmed El-Khouly, Sema Öztürk Yildirim, Ray J. Butcher, Rahime Şimsek, Cihat Şafak   +4 more
doaj   +1 more source

Diclofenac solution (Pennsaid) in the management of osteoarthritis of the knee : Patient implications [PDF]

, 2009
Topical diclofenac sodium (pennsaid) is a non-steroidal-anti- inflammatory drug that is used to manage the recurrent pain and symptoms of osteoarthritis of the knee. Pennsaid is applied topically, absorbed cutaneously and concentrates locally at the site
Banning, M
core  

Synthesis and (spectro)electrochemistry of mixedvalent diferrocenyl–dihydrothiopyran derivatives [PDF]

, 2015
Three novel diferrocenyl complexes were prepared and characterised. 2,2-Diferrocenyl-4,5-dimethyl- 3,6-dihydro-2H-thiopyran (1, sulphide) was accessible by the hetero-Diels–Alder reaction of diferrocenyl thioketone with 2,3-dimethyl-1,3-butadiene ...
Aguirre-Etcheverry, Alexander Hildebrandt, Allen, Barlow, Barrière, Barrière, Becke, Bruno Therrien, Ceccon, Costuas, D'Alessandro, Delgado-Pena, Denifl, Diallo, Diallo, Dominique Miesel, Dong, Dong, Drabowicz, Duggan, Enders, Farrugia, Ferguson, Filipczyk, Fourie, Geiger, Geiger, Gericke, Glover, Gray, Gritzner, Grzegorz Mlostoń, Heinrich Lang, Hildebrandt, Hildebrandt, Hildebrandt, Hildebrandt, Hildebrandt, Hush, Inamoto, Jones, Kaleta, Kaleta, Kienz, Konrad Kowalski, Kotz, Kowalski, Kowalski, Krejcik, Lapinte, Larsen, Lee, Lehrich, Linseis, Lohan, Lohan, Miesel, Mücke, Nafady, Nemykin, Nemykin, O'Connor Salazar, Paul, Petrov, Petrov, Pfaff, Pfaff, Pfaff, Pfaff, Pichlmaier, Poppitz, Rafał Czerwieniec, Rafał Karpowicz, Ratner, Ribou, Robin, Rulkens, Sheldrick, Snyder, Speck, Speck, Swarts, Ward, Weeb, Winter, Xie, Xie, Yamaguchi   +87 more
core   +3 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Dichloridodi-μ2-hydroxido-di-μ3-oxido-octaphenyltetratin(IV) dimethyl sulfoxide disolvate

Acta Crystallographica Section E, 2013
In the centrosymmetric tetranuclear title molecule, [Sn4(C6H5)8Cl2O2(OH)2]·2C2H6OS, the two independent tinIV atoms show distorted trigonal–bipyramidal SnC2O3 and SnC2O2Cl coordination geometries.
Shahrbano Foladi, Parivash Khazaei, Jafar Attar Gharamaleki, Behrouz Notash, Mohammad Kazem Rofouei   +4 more
doaj   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source