Results 21 to 30 of about 2,210 (158)

Whole transcriptome analysis of chemically induced hepatocellular carcinoma using RNA‐sequencing analysis

FEBS Open Bio, 2019
RNA‐sequencing (RNA‐Seq) is a useful method to explore the molecular events in cells and tissues at the transcriptional level. However, comprehensive transcriptome analysis of hepatocarcinogenesis and progression is lacking.
Jie Sun, Jing Wang, Na Zhang, Renjun Yang, Keyang Chen, Derun Kong   +5 more
doaj   +1 more source

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

Molecules, 2018
In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis.
Shiow-Chyn Huang, Pei-Wen Wang, Ping-Chung Kuo, Hsin-Yi Hung, Tai-Long Pan   +4 more
doaj   +1 more source

Acute liver injury induced by low dose dimethylnitrosamine alters mediators of hepatic vascular flow

Toxicology Reports, 2014
Alterations in liver vascular tone play an important role in chronic liver disease. The hepatic stellate cell (HSC) and mediators such as nitric oxide (NO) and hydrogen sulfide (H2S) have been implicated in regulation of vascular tone and intra-hepatic ...
G. Jayakumar Amirtharaj, Kavitha R. Thangaraj, Archana Kini, Raghupathy V., Ashish Goel, Eapen C.E., Aparna Venkatraman, Anna B. Pulimood, Balasubramanian K.A., Anup Ramachandran   +9 more
doaj   +1 more source

Suppression of CB1 cannabinoid receptor by lentivirus mediated small interfering RNA ameliorates hepatic fibrosis in rats. [PDF]

PLoS ONE, 2012
It is recognized that endogenous cannabinoids, which signal through CB1 receptors in hepatic stellate cells (HSCs), exert a profibrotic effect on chronic liver diseases. In this study, we suppressed CB1 expression by lentivirus mediated small interfering
Si-Wen Chen, Ben-Yan Wu, Shi-Ping Xu, Ke-Xing Fan, Li Yan, Yuan Gong, Jun-Bao Wen, Dao-Hong Wu   +7 more
doaj   +1 more source

Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats

BMC Complementary and Alternative Medicine, 2012
Background Macrophages in other organs (e.g. kidneys, lungs, and spleen, et. al) have rarely been reported in the development of liver fibrosis. Therefore, it is important to investigate macrophage activation in the main organs in liver fibrosis.
Chen Xiaorong, Liu Cheng, Lu Yunfei, Yang Zongguo, Lv Zhen, Xu Qingnian, Pan Qi, Lu Lingqing   +7 more
doaj   +1 more source

Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents

Toxicology Reports, 2021
Introduction: Inflammation and oxidative stress are the main factors ascribed with interruption in the process of renal tissue impairment. The toxicity of different types of nitrosamine is well recognized in animals and humans.
Deepika Singh, Deepak Chaudhary, Vikas Kumar, Amita Verma   +3 more
doaj   +1 more source

Antioxidant, antiapoptotic and amino acid balance regulating activities of 1,7-dihydroxy-3,4,8-trimethoxyxanthone against dimethylnitrosamine-induced liver fibrosis. [PDF]

PLoS ONE, 2017
Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injury which could be caused by viral, autoimmune, drugs, and so on.
Xi-Yuan Zheng, Xin Zhao, Ying-Fan Yang, Han-Jie Jiang, Wan Li, Yi Sun, Xiao-Ping Pu   +6 more
doaj   +1 more source

Protective and therapeutic effects of cannabis plant extract on liver cancer induced by dimethylnitrosamine in mice

Alexandria Journal of Medicine, 2014
Hepatocellular carcinomas will emerge as a major form of malignancy in the coming decades. When these tumors are in advanced stages, few therapeutic options are available.
Neveen Abd El Moneim Hussein, Mervat Abd El-Fattah El-Toukhy, Amany Hussein Kazem, Mahmoud El-Said Ali, Mohammad Abd El-Rahman Ahmad, Hossam Mahmoud Rashad Ghazy, Ahmed Mohamed Gamal El-Din   +6 more
doaj   +1 more source

Can apricot kernels fatty acids delay the atrophied hepatocytes from progression to fibrosis in dimethylnitrosamine (DMN)-induced liver injury in rats?

Lipids in Health and Disease, 2011
Background and aims The present study was aimed to analyze the chemical composition of ground apricot kernel (GAK) and examine its effect on hepatic fibrosis in vivo induced by dimethylnitrosamine (DMN) in rats.
Abdel-Rahman Manal K
doaj   +1 more source

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2*

Journal of Lipid Research, 2009
Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P2) in hepatocytes in ...
Hitoshi Ikeda, Naoko Watanabe, Isao Ishii, Tatsuo Shimosawa, Yukio Kume, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Satoko Iitsuka, Ryoto Fujita, Masao Omata, Jerold Chun, Yutaka Yatomi   +14 more
doaj   +1 more source