Results 11 to 20 of about 2,282 (176)

Alterations in Gut Microbiota and Metabolism in Cirrhotic Portal Hypertension: Implications for Disease Progression. [PDF]

Aliment Pharmacol Ther
In‐depth multiomics analyses revealed that the gut microbiota in patients with CPH is dysbiotic. Altered gut microbiota plays an important role in the progression of CPH and affects the host's arginine metabolism to promote arginine biosynthesis. The pro‐inflammatory effects of certain gut bacteria induce iNOS expression, which together act on the ...
Zhang Q, Cui J, Hou Y, Guo L, Li H, Zhou G, Wang X, Zhu B, Shi K, Zhang Y, Bi Y, Li Y, Sun L, Feng Y, Yuan J, Wang X.   +15 more
europepmc   +2 more sources

A <i>Lactiplantibacillus plantarum</i>AL6-1 Strain Isolated From Air-Dried Meat Mitigates N-Dimethylnitrosamine-Induced Hepatic Injury in Mice. [PDF]

Food Sci Nutr
Genome analysis identified genes associated with NDMA metabolism and antioxidation. L. plantarum AL6‐1 alleviates NDMA‐induced liver injury in mice. L. plantarum AL6‐1 regulates liver metabolic enzymes to reduce NDMA toxicity. ABSTRACT Excessive intake of N‐dimethylnitrosamine (NDMA) can lead to liver damage and carries a potential carcinogenic risk ...
Sun E, Sun X, Guo J, Sun L, Jin Y, Zhao L, Su L.   +6 more
europepmc   +2 more sources

Rodent monocyte-derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians. [PDF]

Dev Dyn
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Saito Y, Fujiwara Y, Yamaguchi YL, Tanaka SS, Miura K, Hizukuri Y, Yamashiro K, Hayashi Y, Nakashima Y, Komohara Y.   +9 more
europepmc   +2 more sources

Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats

Drug Delivery, 2022
Cranberry extract (CBE) is a major source of the antioxidant polyphenolics but suffers from limited bioavailability. The goal of this research was to encapsulate the nutraceutical (CBE), into bile salt augmented liposomes (BSALs) as a promising oral ...
Sara M. Soliman, Shaimaa Mosallam, Mohamed A. Mamdouh, Mohammed Abdalla Hussein, Shady M. Abd El-Halim   +4 more
doaj   +1 more source

PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1

Cell Reports, 2023
Summary: Pancreatic progenitor cell differentiation and proliferation factor (PPDPF) has been reported to play a role in tumorigenesis. However, its function in hepatocellular carcinoma (HCC) remains poorly understood. In this study, we report that PPDPF
Yi-Kang Wang, Ning Ma, Sheng Xu, Jing-Yi Huang, Qian-Zhi Ni, Hui-Jun Cao, Qian-Wen Zheng, Bing Zhu, Ji Xia, Feng-Kun Zhang, Xu-Fen Ding, Xiao-Song Qiu, Tian-Wei Chen, Kang Wang, Wei Chen, Zhi-Gang Li, Shu-Qun Cheng, Dong Xie, Jing-Jing Li   +18 more
doaj   +1 more source

Cnidoscolus aconitifolius leaf extract and ascorbate confer amelioration and protection against dimethyl nitrosamine-induced renal toxicity and testicular abnormalities in rats

Toxicology Reports, 2021
Extracts of Cnidoscolus aconitifolius (CA) have been reported to possess medicinal properties ranging from potential hepatoprotective, anti-diabetic, and anti-cardiovascular. In our previous study, gas chromatography mass spectroscopy check of CA extract
Oluwatobi T. Somade, Regina N. Ugbaja, Mopelola A. Idowu, Oluseyi A. Akinloye   +3 more
doaj   +1 more source

Transgenerational Reproductive and Developmental Toxicity Induced by N-Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster. [PDF]

J Appl Toxicol
ABSTRACT N‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as a potent hepatotoxin, promutagen, and probable human carcinogen; this is because of the metabolites associated with its biotransformation. The metabolism of NDMA produces formaldehyde, another alkylating agent and DBP. Both compounds are generated from
Tabares-Mosquera OE, Juárez-Díaz JA, Camacho-Carranza R, Ramos-Morales P.   +3 more
europepmc   +2 more sources

Cnidoscolus aconitifolius leaf extract exhibits comparable ameliorative potentials with ascorbate in dimethylnitrosamine-induced bone marrow clastogenicity and hepatotoxicity

Clinical Nutrition Experimental, 2020
Summary: Cnidoscolus aconitifolius (CA) is an edible perennial shrub with promising medicinal properties. We therefore investigated the ameliorative potentials of CA (400 mg/kg) by comparing with ascorbate (400 mg/kg) in dimethylnitrosamine (DMN)-induced
Oluwatobi T. Somade, Oluseyi A. Akinloye, Regina N. Ugbaja, Mopelola A. Idowu   +3 more
doaj   +1 more source

PRECLINICAL MODELS OF LIVER CÂNCER [PDF]

Arquivos de Gastroenterologia, 2023
Background: This manuscript provides an overview of liver carcinogenesis in murine models of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Objective: A review through MEDLINE and EMBASE was performed to assess articles until August 2022.
Flávio Henrique Ferreira GALVÃO, Maria Clara Camargo TRALDI, Renata Sandres Souza ARAÚJO, Jose Tadeu STEFANO, Luiz Augusto Carneiro D’ALBUQUERQUE, Claudia P OLIVEIRA   +5 more
doaj   +1 more source

NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats. [PDF]

PLoS ONE, 2011
Liver fibrosis is a worldwide clinical issue. It has been well established that activated hepatic stellate cells (HSCs) are responsible for excessive extracellular matrix (ECM) deposition in chronically damaged livers.
Jiandong Yang, Jin Zheng, Lin Wu, Ming Shi, Hongtao Zhang, Xing Wang, Ning Xia, Desheng Wang, Xinping Liu, Libo Yao, Yan Li, Kefeng Dou   +11 more
doaj   +1 more source