Results 21 to 30 of about 2,282 (176)

Some Toxic Properties of Dimethylnitrosamine [PDF]

Occupational and Environmental Medicine, 1954
The appearance of two cases of cirrhosis of the liver among three men working in the research laboratory of a large industrial undertaking led to suspicion becoming attached to dimethylnitrosamine (D.M.N.) as the causative agent. Dimethylnitro samine had been introduced into the laboratory as a solvent about 10 months before the first case of cirrhosis
J M, BARNES, P N, MAGEE
openaire   +2 more sources

The morphofunctional and biochemical characteristics of opisthorchiasis-associated cholangiocarcinoma in a Syrian hamster model

Вавиловский журнал генетики и селекции, 2015
The validity of experimental models of pathologies is one of the key challenges in translational medicine. Cholangiocarcinoma, or bile duct cancer, ranks second among oncological diseases of the liver.
G. A. Maksimova, M. Y. Pakharukova, E. V. Kashina, N. A. Zhukova, M. N. Lvova, M. V. Khvostov, D. S. Baev, A. V. Katokhin, T. G. Tolstikova, V. A. Mordvinov   +9 more
doaj   +1 more source

Whole transcriptome analysis of chemically induced hepatocellular carcinoma using RNA‐sequencing analysis

FEBS Open Bio, 2019
RNA‐sequencing (RNA‐Seq) is a useful method to explore the molecular events in cells and tissues at the transcriptional level. However, comprehensive transcriptome analysis of hepatocarcinogenesis and progression is lacking.
Jie Sun, Jing Wang, Na Zhang, Renjun Yang, Keyang Chen, Derun Kong   +5 more
doaj   +1 more source

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

Molecules, 2018
In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis.
Shiow-Chyn Huang, Pei-Wen Wang, Ping-Chung Kuo, Hsin-Yi Hung, Tai-Long Pan   +4 more
doaj   +1 more source

Acute liver injury induced by low dose dimethylnitrosamine alters mediators of hepatic vascular flow

Toxicology Reports, 2014
Alterations in liver vascular tone play an important role in chronic liver disease. The hepatic stellate cell (HSC) and mediators such as nitric oxide (NO) and hydrogen sulfide (H2S) have been implicated in regulation of vascular tone and intra-hepatic ...
G. Jayakumar Amirtharaj, Kavitha R. Thangaraj, Archana Kini, Raghupathy V., Ashish Goel, Eapen C.E., Aparna Venkatraman, Anna B. Pulimood, Balasubramanian K.A., Anup Ramachandran   +9 more
doaj   +1 more source

Suppression of CB1 cannabinoid receptor by lentivirus mediated small interfering RNA ameliorates hepatic fibrosis in rats. [PDF]

PLoS ONE, 2012
It is recognized that endogenous cannabinoids, which signal through CB1 receptors in hepatic stellate cells (HSCs), exert a profibrotic effect on chronic liver diseases. In this study, we suppressed CB1 expression by lentivirus mediated small interfering
Si-Wen Chen, Ben-Yan Wu, Shi-Ping Xu, Ke-Xing Fan, Li Yan, Yuan Gong, Jun-Bao Wen, Dao-Hong Wu   +7 more
doaj   +1 more source

Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats

BMC Complementary and Alternative Medicine, 2012
Background Macrophages in other organs (e.g. kidneys, lungs, and spleen, et. al) have rarely been reported in the development of liver fibrosis. Therefore, it is important to investigate macrophage activation in the main organs in liver fibrosis.
Chen Xiaorong, Liu Cheng, Lu Yunfei, Yang Zongguo, Lv Zhen, Xu Qingnian, Pan Qi, Lu Lingqing   +7 more
doaj   +1 more source

A novel chronic cirrhosis TAA-induced model in rats

Brazilian Journal of Veterinary Pathology, 2010
Experimental models for hepatic lesions are necessary so the effectiveness of new drugs in reversing cirrhosis or fibrosis can be tested. This is the case of liver cirrhosis, which requires animal models.
Ricardo R. Guerra, Maurício R. Trotta, Thiago P. A. Aloia, Maria L. Z. Dagli, Francisco J. Hernandez-Blazquez   +4 more
doaj   +1 more source

Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents

Toxicology Reports, 2021
Introduction: Inflammation and oxidative stress are the main factors ascribed with interruption in the process of renal tissue impairment. The toxicity of different types of nitrosamine is well recognized in animals and humans.
Deepika Singh, Deepak Chaudhary, Vikas Kumar, Amita Verma   +3 more
doaj   +1 more source

Antioxidant, antiapoptotic and amino acid balance regulating activities of 1,7-dihydroxy-3,4,8-trimethoxyxanthone against dimethylnitrosamine-induced liver fibrosis. [PDF]

PLoS ONE, 2017
Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injury which could be caused by viral, autoimmune, drugs, and so on.
Xi-Yuan Zheng, Xin Zhao, Ying-Fan Yang, Han-Jie Jiang, Wan Li, Yi Sun, Xiao-Ping Pu   +6 more
doaj   +1 more source