Results 51 to 60 of about 2,210 (158)

A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats

The Scientific World Journal, 2014
Jia-wei-xiao-yao-san (JWXYS) is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders. Only a few of the hepatoprotective effects of JWXYS have been studied.
Shu-Chen Chien, Wei-Chiao Chang, Pu-Hua Lin, Wei-Pin Chang, Shih-Chung Hsu, Jung-Chen Chang, Ya-Chieh Wu, Jin-Kuo Pei, Chia-Hsien Lin   +8 more
doaj   +1 more source

Hepatoprotective effect of genistein against dimethylnitrosamine-induced liver fibrosis in rats by regulating macrophage functional properties and inhibiting the JAK2/STAT3/SOCS3 signaling pathway

Frontiers in Bioscience-Landmark, 2021
Background: Liver fibrosis is a dysregulated wound-healing process in response to diverse liver injuries, and an effective drug therapy is not yet available.
Ying Xu, Dingqi Zhang, Hailin Yang, Yu Liu, Linzhang Zhang, Congcong Zhang, Gaofeng Chen, Yonghong Hu, Jiamei Chen, Hua Zhang, Yongping Mu, Ping Liu, Wei Liu   +12 more
doaj   +1 more source

MiR-21 simultaneously regulates ERK1 signaling in HSC activation and hepatocyte EMT in hepatic fibrosis. [PDF]

PLoS ONE, 2014
BACKGROUND:MicroRNA-21 (miR-21) plays an important role in the pathogenesis and progression of liver fibrosis. Here, we determined the serum and hepatic content of miR-21 in patients with liver cirrhosis and rats with dimethylnitrosamine-induced hepatic ...
Juan Zhao, Nan Tang, Kaiming Wu, Weiping Dai, Changhong Ye, Jian Shi, Junping Zhang, Beifang Ning, Xin Zeng, Yong Lin   +9 more
doaj   +1 more source

Continuous Intravenous Infusion of Hepatocyte Growth Factor Promotes the Development of a Fibrolytic Phenotype in Hepatic Macrophages and Stellate Cells in a Rat Model of Bile Duct Ligation

Hepatology Research, Volume 55, Issue 9, Page 1307-1319, September 2025.
This study demonstrates that continuous intravenous infusion of hepatocyte growth factor can significantly reduce liver fibrosis in rats. This treatment promotes hepatocyte regeneration and reduces harmful inflammation, offering promising potential as a therapy for liver cirrhosis in humans. ABSTRACT Aim Liver cirrhosis is a severe condition that often
Oki Taniyama, Kotaro Kumagai, Shuji Kanmura, Yuko Nakamura, Hiromi Eguchi, Miho Uehara, Kyoko Meguro, Ai Toyodome, Sho Ijuin, Haruka Sakae, Kazuaki Tabu, Kohei Oda, Seiichi Mawatari, Keisuke Yano, Satoshi Ieiri, Akio Ido   +15 more
wiley   +1 more source

Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro. [PDF]

PLoS ONE, 2013
BACKGROUND: Graptopetalum paraguayense (GP) is a folk herbal medicine with hepatoprotective effects that is used in Taiwan. The aim of this study was to evaluate the hepatoprotective and antifibrotic effects of GP on experimental hepatic fibrosis in both
Li-Jen Su, Chia-Chuan Chang, Chih-Hsueh Yang, Shur-Jong Hsieh, Yi-Chin Wu, Jin-Mei Lai, Tzu-Ling Tseng, Chi-Ying F Huang, Shih-Lan Hsu   +8 more
doaj   +1 more source

Evaluating the Effectiveness of Pegbelfermin in MASH‐Associated Hepatic Fibrosis A Meta‐Analysis and Systematic Review of Randomized Controlled Trials

JGH Open, Volume 9, Issue 3, March 2025.
ABSTRACT Introduction Metabolic dysfunction‐associated steatohepatitis (MASH), an advanced form of fatty liver disease, is characterized by liver inflammation and fibrosis, with an emerging interest in fibroblast growth factor (FGF)‐21 analogs, particularly pegbelfermin (PGBF).
Muhammad Shahzil, Fariha Hasan, Syeda Kanza Kazmi, Manesh Kumar Gangwani, UmmeSalma Shabbar, Ammad Javaid Chaudhary, Muhammad Ali Khaqan, Muhammad Saad Faisal, Kathy N. Williams, Babu P. Mohan, Christina Tofani   +10 more
wiley   +1 more source

Tramadol-induced hepato- and nephrotoxicity in rats: Role of Curcumin and Gallic acid as antioxidants. [PDF]

PLoS ONE, 2018
Tramadol is an analgesic used to treat moderate to severe pain caused by cancer, osteoarthritis, and other musculoskeletal diseases. Cytochrome P450 system metabolizes tramadol and induces oxidative stress in different organs.
Salah A Sheweita, Ainour A Almasmari, Sabah G El-Banna   +2 more
doaj   +1 more source

Phytotherapy for Liver Fibrosis: Insights From the Biology of Hepatic Stellate Cells—A Narrative Review

Liver International Communications, Volume 6, Issue 1, March 2025.
ABSTRACT Chronic liver diseases frequently progress to liver fibrosis, characterized by the accumulation of extracellular matrix (ECM) proteins and the formation of fibrous scars. This fibrous tissue disrupts normal liver architecture, impairing its physiological functions.
Sathish Kumar Mungamuri, Nabanita Chatterjee, Dilkash Ara   +2 more
wiley   +1 more source

The Status and Emerging Developments in Laboratory Animal Science in Asia since 9th AFLAS Congress (2023) until 10th AFLAS Congress (2025)

Animal Models and Experimental Medicine, Volume 8, Issue 12, Page 2157-2175, December 2025.
Asian Federation of Laboratory Animal Science Associations (AFLAS)
wiley   +1 more source

Sinapic Acid Attenuates Hypertrophic Scarring by Modulating the TGF‐β1/Smad Pathway: An In Vivo and In Vitro Investigation

International Journal of Clinical Practice, Volume 2025, Issue 1, 2025.
Rationale Hypertrophic scars are formed as a result of excess collagen and fibroblast activity during the tissue healing process and can result in loss of function. Sinapic acid (SA) is a naturally occurring phenolic compound with antifibrotic, anti‐inflammatory, and antioxidant properties. Aims and Objectives This study aims to evaluate the ability of
Zhe Jin, Libo Yin, Zhiguang Huang, Suraiya Saleem   +3 more
wiley   +1 more source