Results 61 to 70 of about 2,282 (176)

Evaluating the Effectiveness of Pegbelfermin in MASH‐Associated Hepatic Fibrosis A Meta‐Analysis and Systematic Review of Randomized Controlled Trials

JGH Open, Volume 9, Issue 3, March 2025.
ABSTRACT Introduction Metabolic dysfunction‐associated steatohepatitis (MASH), an advanced form of fatty liver disease, is characterized by liver inflammation and fibrosis, with an emerging interest in fibroblast growth factor (FGF)‐21 analogs, particularly pegbelfermin (PGBF).
Muhammad Shahzil, Fariha Hasan, Syeda Kanza Kazmi, Manesh Kumar Gangwani, UmmeSalma Shabbar, Ammad Javaid Chaudhary, Muhammad Ali Khaqan, Muhammad Saad Faisal, Kathy N. Williams, Babu P. Mohan, Christina Tofani   +10 more
wiley   +1 more source

Biochemical and Molecular Mechanisms of Platelet-Rich Plasma in Ameliorating Liver Fibrosis Induced by Dimethylnitrosurea

Cellular Physiology and Biochemistry, 2018
Background/Aims: Hepatic fibrosis is a wound-healing process in the chronically injured liver. Clinical application of platelet-rich plasma (PRP) is of considerable interest for wound healing and regeneration.
Neveen A. Salem, Amal Hamza, Hanan Alnahdi, Najla Ayaz   +3 more
doaj   +1 more source

Phytotherapy for Liver Fibrosis: Insights From the Biology of Hepatic Stellate Cells—A Narrative Review

Liver International Communications, Volume 6, Issue 1, March 2025.
ABSTRACT Chronic liver diseases frequently progress to liver fibrosis, characterized by the accumulation of extracellular matrix (ECM) proteins and the formation of fibrous scars. This fibrous tissue disrupts normal liver architecture, impairing its physiological functions.
Sathish Kumar Mungamuri, Nabanita Chatterjee, Dilkash Ara   +2 more
wiley   +1 more source

Histopathological and biochemical effects of green tea and/or licorice aqueous extracts on thyroid functions in male albino rats intoxicated with dimethylnitrosamine

Nutrition & Metabolism, 2009
Objective To investigate histopathological and biochemical effects of green tea and/or licorice aqueous extracts in thyroid functions in male albino rats intoxicated with Dimethylnitrosamine. Methods 40 Male albino rats were divided into two main groups,
Mohamed U, Bstawi M, El Mgeed A Abd, Gabbar M Abdel   +3 more
doaj   +1 more source

Induction of Dimethylnitrosamine-demethylase by Polar Solvents

Experimental Biology and Medicine, 1980
SummaryThe polar compounds acetone, dioxane, tetrahydrofuran, di-methylsulfoxide, trioctanoin, and polyoxyethylene sorbitan monooleate (Tween 80) induce the activity of hepatic dimethylnitrosamine-demethylase I, a mixed-function oxidase repressed by typi-cal inducer agents such as 3-methylcholanthrene and phenobarbital. The highest activity was reached
M F, Argus, B J, Neuburger, S C, Myers, J C, Arcos   +3 more
openaire   +2 more sources

The Status and Emerging Developments in Laboratory Animal Science in Asia since 9th AFLAS Congress (2023) until 10th AFLAS Congress (2025)

Animal Models and Experimental Medicine, Volume 8, Issue 12, Page 2157-2175, December 2025.
Asian Federation of Laboratory Animal Science Associations (AFLAS)
wiley   +1 more source

Experimental models for induction of liver cirrhosis in animals: a review [PDF]

Biotemas, 2010
The liver plays a key role in the homeostatic balance of many biological processes. Cirrhosis is a syndrome in which chronic liver diseases converge, leading to hepatocellular injury, the exacerbated deposition of fibrous tissue, and eventually the ...
Cristiane Carlin Passos, Amanda Olivotti Ferreira, Francisco Javier Hernandez Blazquez, Ricardo Romão Guerra   +3 more
doaj  

Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells

Protein & Cell, 2016
Matrine (MT), the effective component of Sophora flavescens Ait, has been shown to have anti-inflammation, immune-suppressive, anti-tumor, and anti-hepatic fibrosis activities.
Yi Feng, Hai-yan Ying, Ying Qu, Xiao-bo Cai, Ming-yi Xu, Lun-gen Lu   +5 more
doaj   +1 more source

A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis

Journal of Translational Medicine, 2019
Background and aims Glutathione S-transferase A3 (GSTA3) is known as an antioxidative protease, however, the crucial role of GSTA3 in liver fibrosis remains unclear.
Haihua Chen, Qixin Gan, Congying Yang, Xiongqun Peng, Jiao Qin, Sisi Qiu, Yanzhi Jiang, Sha Tu, Ying He, Shenglan Li, Huixiang Yang, Lijian Tao, Yu Peng   +12 more
doaj   +1 more source

Characterization of the Roles of Vimentin in Regulating the Proliferation and Migration of HSCs during Hepatic Fibrogenesis

Cells, 2019
The activation of hepatic stellate cells (HSCs) manifested as proliferation and migration is the pivotal event involved in liver fibrogenesis. The vimentin network, an intermediate filament (IF) system, is one of the critical cascades by which the cell ...
Pei-Wen Wang, Tung-Ho Wu, Tung-Yi Lin, Mu-Hong Chen, Chau-Ting Yeh, Tai-Long Pan   +5 more
doaj   +1 more source