Results 51 to 60 of about 2,282 (176)

A combined “eat me/don’t eat me” strategy based on exosome for acute liver injury treatment

Cell Reports Medicine
Summary: Drug-induced liver injury (DILI) involves multifaceted pathogenesis, necessitating effective therapeutic strategies. Wnt2, secreted by liver sinusoidal endothelial cell (LSEC), activates the Wnt/β-catenin signaling pathway to promote hepatocyte ...
Wei Du, Chen Chen, YingYing Liu, Huiyi Quan, Ming Xu, JingJing Liu, Ping Song, ZhiQiang Fang, ZhenSheng Yue, Hao Xu, YuWei Ling, JuanLi Duan, Fei He, Lin Wang   +13 more
doaj   +1 more source

A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats

The Scientific World Journal, 2014
Jia-wei-xiao-yao-san (JWXYS) is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders. Only a few of the hepatoprotective effects of JWXYS have been studied.
Shu-Chen Chien, Wei-Chiao Chang, Pu-Hua Lin, Wei-Pin Chang, Shih-Chung Hsu, Jung-Chen Chang, Ya-Chieh Wu, Jin-Kuo Pei, Chia-Hsien Lin   +8 more
doaj   +1 more source

Study of the therapeutic effects of Lactobacillus and α-lipoic acid against dimethylnitrosamine-induced liver fibrosis in rats

Journal of Genetic Engineering and Biotechnology, 2014
Lactobacillus (LB) and α-lipoic acid (ALA) were investigated to compare their protective effects against dimethylnitrosamine (DMN)-induced liver fibrosis in rats. Animals were either injected intraperitoneally with DMN to induce hepatic fibrosis, or were
Khairy M.A. Zoheir, Amro A. Amara, S.F. Ahmad, Mahmoud A. Mohammad, Abdelkader E. Ashour, Gamaleldin I. Harisa, Adel R. Abd-Allah   +6 more
doaj   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, Volume 66, Issue S2, Page 101-120, December 2025.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Yinchenhao Decoction Alleviates Liver Fibrosis by Regulating Bile Acid Metabolism and TGF-β/Smad/ERK Signalling Pathway

Scientific Reports, 2018
Yinchenhao decoction (YCHD), comprising Yinchenhao (Artemisiae Scopariae Herba), Zhizi (Gardeniae Fructus) and Dahuang (Radix Rhei et Rhizoma), is widely used for treating various diseases.
Fei-Fei Cai, Rong Wu, Ya-Nan Song, Ai-Zhen Xiong, Xiao-Le Chen, Meng-Die Yang, Li Yang, Yuanjia Hu, Ming-Yu Sun, Shi-Bing Su   +9 more
doaj   +1 more source

MiR-21 simultaneously regulates ERK1 signaling in HSC activation and hepatocyte EMT in hepatic fibrosis. [PDF]

PLoS ONE, 2014
BACKGROUND:MicroRNA-21 (miR-21) plays an important role in the pathogenesis and progression of liver fibrosis. Here, we determined the serum and hepatic content of miR-21 in patients with liver cirrhosis and rats with dimethylnitrosamine-induced hepatic ...
Juan Zhao, Nan Tang, Kaiming Wu, Weiping Dai, Changhong Ye, Jian Shi, Junping Zhang, Beifang Ning, Xin Zeng, Yong Lin   +9 more
doaj   +1 more source

Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
In this review, we summarize cell–ECM interactions and delve into the complex mechanotransduction. We introduce advanced research methods and emerging clinical tools used to study cellular mechanical phenotypes, mechanotransduction, and disease progression. Additionally, we analyze the role of mechanical biomarkers in the development and progression of
Yicen Long, Peng Wang, Jiacheng Lei, Baihai Su, Qiang Wei, Xiaojing Liu   +5 more
wiley   +1 more source

Efferocytosis in Health and Disease

MedComm, Volume 6, Issue 12, December 2025.
Efferocytosis in health and disease. Efferocytosis integrates apoptotic cell recognition, engulfment, digestion, and reprogramming to link cell clearance with tissue repair. Molecular checkpoints balance “eat‐me” signals such as phosphatidylserine against inhibitory “don't‐eat‐me” cues like CD47, while TAM receptors, scavenger receptors, and integrins ...
Chaofu Li, Yukun Yang, Fating Zhou, Qiuyan Jiang, Yingying Jiang, Xuanjie Huang, Yiqiong Zhang, Zhengmeng Ye, Gang Xu, Guoying Kao, Ke Zhou, Fan Yang, Jun Xiao, Wei Wu, Chuanwei Li   +14 more
wiley   +1 more source

Graptopetalum paraguayense ameliorates chemical-induced rat hepatic fibrosis in vivo and inactivates stellate cells and Kupffer cells in vitro. [PDF]

PLoS ONE, 2013
BACKGROUND: Graptopetalum paraguayense (GP) is a folk herbal medicine with hepatoprotective effects that is used in Taiwan. The aim of this study was to evaluate the hepatoprotective and antifibrotic effects of GP on experimental hepatic fibrosis in both
Li-Jen Su, Chia-Chuan Chang, Chih-Hsueh Yang, Shur-Jong Hsieh, Yi-Chin Wu, Jin-Mei Lai, Tzu-Ling Tseng, Chi-Ying F Huang, Shih-Lan Hsu   +8 more
doaj   +1 more source

Continuous Intravenous Infusion of Hepatocyte Growth Factor Promotes the Development of a Fibrolytic Phenotype in Hepatic Macrophages and Stellate Cells in a Rat Model of Bile Duct Ligation

Hepatology Research, Volume 55, Issue 9, Page 1307-1319, September 2025.
This study demonstrates that continuous intravenous infusion of hepatocyte growth factor can significantly reduce liver fibrosis in rats. This treatment promotes hepatocyte regeneration and reduces harmful inflammation, offering promising potential as a therapy for liver cirrhosis in humans. ABSTRACT Aim Liver cirrhosis is a severe condition that often
Oki Taniyama, Kotaro Kumagai, Shuji Kanmura, Yuko Nakamura, Hiromi Eguchi, Miho Uehara, Kyoko Meguro, Ai Toyodome, Sho Ijuin, Haruka Sakae, Kazuaki Tabu, Kohei Oda, Seiichi Mawatari, Keisuke Yano, Satoshi Ieiri, Akio Ido   +15 more
wiley   +1 more source