Results 161 to 170 of about 2,930 (198)
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N,N-Dimethyltryptamine: An Endogenous Hallucinogen
1981Publisher Summary This chapter reviews the biosynthesis, metabolism, pharmacology, and properties of N,N-dimethyltryptamine (DMT), leading to a conclusion that DMT may be a neurotransmitter in the mammalian brain. The identification of DMT and other hallucinogens in man explains the experience of hallucinatory phenomena in general.
S A, Barker, J A, Monti, S T, Christian
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In vivo metabolism of 5-methoxy-N, N-dimethyltryptamine and N,N-dimethyltryptamine in the rat
Biochemical Pharmacology, 1987Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N ...
B R, Sitaram +4 more
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A Dimethyltryptamine-Forming Enzyme in Human Blood
American Journal of Psychiatry, 1973An enzyme capable of forming the hallucinogen dimethyltryptamine was found in human red blood cells, plasma, and platelets. The enzyme activity in red blood cells and plasma was not significantly different in psychiatric patients from that in normal subjects.
R J, Wyatt, J M, Saavedra, J, Axelrod
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Urinary dimethyltryptamine and psychiatric symptomatology and classification
Psychological Medicine, 1977SynopsisThe excretion of dimethyltryptamine (DMT) was studied amongst 122 recently admitted psychiatric patients and 20 normal subjects. DMT was detected in the urine of 47% of those diagnosed by their psychiatrists as schizophrenic, 38% of those with other non-affective psychoses, 13% of those with affective psychoses, 19% of those with neurotic and ...
R, Rodnight +5 more
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Urinary Excretion of Dimethyltryptamine in Liver Disease
American Journal of Psychiatry, 1979The urinary excretion of N,N-dimethyltryptamine (DMT) was higher in patients with severe liver disease than in normal subjects. This difference remained significant when patients with all grades of hepatic encephalopathy were excluded. Patients with liver disease whose mental states were normal excreted amounts of DMT similar to those of patients with ...
S A, Checkley +5 more
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Human psychopharmacology of N,N-dimethyltryptamine
Behavioural Brain Research, 1995We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological and psychological outcome measures. Subjective responses were quantified with a new rating scale, the HRS, which provided better resolution of dose effects ...
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Persistent Tinnitus after Inhaled N,N-dimethyltryptamine (DMT)
Journal of Psychoactive Drugs, 2020This case report describes a 39-year-old male with remote history of polysubstance use disorder and depression who developed tinnitus after use of inhaled N,N-dimethyltryptamine (DMT). Although development of ear ringing was attributed to use on a single occasion, tinnitus occurred within the context of a larger self-experiment involving weekly ...
Heba Diab, Benjamin Malcolm
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A new metabolic pathway for N,N-dimethyltryptamine
Biological Psychiatry, 1986N,N-Dimethyltryptamine (DMT) undergoes a major structural alteration when added to whole human blood or its red blood cells in vitro. A new high-pressure liquid chromatography (HPLC) peak is present in extracts of these treated tissues. The compound responsible for this peak has been identified by ultraviolet spectrophotometry and by mass spectrometry ...
L M, Hryhorczuk +3 more
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Phytochemistry, 1972
Abstract The biosynthesis and turnover of N , N -dimethyltryptamine and 5-methoxy- N , N -dimethyltryptamine have been studied in the pasture grass Phalaris tuberosa by a combination of feeding and trapping experiments using radioisotopically labelled compounds. Their turnover has been demonstrated by feeding tryptophan and tryptamine.
Claire Baxter, M. Slaytor
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Abstract The biosynthesis and turnover of N , N -dimethyltryptamine and 5-methoxy- N , N -dimethyltryptamine have been studied in the pasture grass Phalaris tuberosa by a combination of feeding and trapping experiments using radioisotopically labelled compounds. Their turnover has been demonstrated by feeding tryptophan and tryptamine.
Claire Baxter, M. Slaytor
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Dimethyltryptamine, A Do-It-Yourself Hallucinogenic Drug
JAMA: The Journal of the American Medical Association, 1967To the Editor:— Almost immediately after the hallucinogenic effects of drugs such as mescaline, LSD, and peyote were made known, legal and medical restrictions were applied. Those nonmedical individuals who were determined to experience the hallucinatory effects sought illegal supply channels. As restrictions became more effective, the availability of
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