Results 31 to 40 of about 1,491 (156)

2,4-Dinitrophenol, the inferno drug: a netnographic study of user experiences in the quest for leanness. [PDF]

, 2016
Background: Despite not being licensed for human consumption, the Internet has triggered renewed, widespread interest and availability of 2,4-Dinitrophenol (DNP).
BBC, Cann H. M., Cullen P., Duchaine D., Evans-Brown M., Gillham B., Hamilton A., Hecht A., Jennifer Germain, Jim McVeigh, Kurt T. L., Le P., Llewellyn W., Marie Claire Van Hout, Matharu H., McFee R. B., Morris S, Reuter P., Rheingold H., Saba V. K., Sawer P., Wallendorf M., Wise J.   +22 more
core   +1 more source

Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Targeted protein degradation based on LYTAC technology has recently emerged as a research hotspot in various diseases. The membrane receptors recently utilized in LYTAC design are summarized in this article, with insights into current strategies, challenges, and prospects for LYTAC‐based technologies.
Lijian Shen, Ziyi Liang, Ying Zhang, Jing Wen, Jie Gao   +4 more
wiley   +1 more source

Antibody Polyreactivity: A Challenger of Immune Paradigms

Immunology, Volume 176, Issue 4, Page 421-437, December 2025.
This review article discusses the definition and functions of polyreactive antibodies, as well as their physiological roles. It also presents the concept of polyreactivity as a challenger of immunological dogmas. ABSTRACT Polyreactivity refers to the ability of antibodies to bind multiple unrelated antigens, encompassing polyspecificity and promiscuity.
Anastas D. Pashov, Jordan D. Dimitrov
wiley   +1 more source

Quantitative Structure-Permeation Relationships for Solute Transport Across Silicone Membranes [PDF]

, 2018
Purpose. The purpose of this work was to assess the molecular properties that influence solute permeation across silicone membranes and to compare the results with transport across human skin. Methods.
Boss, Gilles, Bunge, Annette, Carrupt, Pierre-Alain, Geinoz, Sandrine, Guy, Richard, Reist, Marianne, Rey, Sebastien, Testa, Bernard   +7 more
core  

Automated Analysis of Pollutants in Wastewater Using Atmospheric Pressure Gas Chromatography‐Tandem Quadrupole Mass Spectrometer With Robotic Autosampler and Solid Phase Micro Extraction

Journal of Separation Science, Volume 48, Issue 11, November 2025.
ABSTRACT The analysis of organic pollutants using gas chromatography coupled to mass spectrometer (GC‐MS) with electron impact (EI) ionization and liquid–liquid or solid‐phase extraction (LLE or SPE) often suffer from a limited selectivity and arduous sample preparation.
Dnyaneshwar Shinde, Urvikkumar Dhagat, Vijayakumar Murugan, Parth Gupta, Raghu Tadala, Bhaskar Karubothula, Chaitanya Devireddy, Edward Stanislaus, Samara Bin Salem, Wael Elamin, Grzegorz Brudecki   +10 more
wiley   +1 more source

In search of an optimal acid-base indicator for examining surfactant micelles:Spectrophotometric studies and molecular dynamics simulations [PDF]

, 2019
We report on combined experimental and theoretical investigations of the water/micelle interface of cationic, anionic, zwitterionic, and non-ionic surfactants using a new hydrophobic acid-base indicator 2,6-dinitro-4-n-dodecylphenol.
Cheipesh, Tatyana A., Farafonov, Vladimir S., Lebed, Alexander V., Mchedlov-Petrossyan, Nikolay O., Nerukh, Dmitry A., Shekhovtsov, Sergey V.   +5 more
core   +1 more source

Time Constraints Modulate the Effects of Predator Cues and a Metal Across Life Stages in a Damselfly

Evolutionary Applications, Volume 18, Issue 11, November 2025.
ABSTRACT Animals are increasingly exposed to multiple co‐occurring stressors. Environmental factors such as seasonal time constraints (TC), predation risk, and pollutants strongly influence fitness‐related traits in aquatic organisms. Yet, the interactive effects of such stressors, especially across life stages, remain unclear.
Nermeen R. Amer, Maria J. Golab, Robby Stoks, Guillaume Wos, Szymon Sniegula   +4 more
wiley   +1 more source

Acidity Controlled Formal Nucleophilic Substitution of Hydrofluoroolefin‐Based Iodonium Salt with O‐nucleophiles: Synthetic Application and Mechanistic Study

Chemistry – A European Journal, Volume 31, Issue 56, October 8, 2025.
A new method using hypervalent iodonium species derived from hydrofluoroolefin gas enables fast, mild, and efficient synthesis of fluoroalkyl ethers from phenols. Experimental and DFT mechanistic studies show that phenol acidity influences the reaction pathway.
János T. Csenki, Dóra F. Englert, Dániel Steinsits, Péter P. Fehér, András Stirling, Zoltán Novák   +5 more
wiley   +1 more source

Identifying Gene Predictors of Chemicals Linked With Breast Cancer: A Machine Learning Analysis of MCF7 Cellular Transcriptomic Screening Data

Environmental and Molecular Mutagenesis, Volume 66, Issue 8, Page 425-441, October 2025.
ABSTRACT Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing data from human breast cancer‐derived MCF7 cells exposed to hundreds of individual chemicals.
Lauren E. Koval, Richard Judson, Julia E. Rager   +2 more
wiley   +1 more source

Natural Mutation in Naked Mole‐Rat UCP1 Refutes Importance of the Histidine Pair Motif for Proton Conductance and Thermogenesis

Acta Physiologica, Volume 241, Issue 10, October 2025.
ABSTRACT Aim Uncoupling protein 1 (UCP1) is the crucial protein for non‐shivering thermogenesis in placental mammals, but the molecular mechanism of thermogenic proton transport is still unknown. Its histidine pair motif (H145 and H147) has been claimed as a critical element for proton translocation, leading to the paradigmatic “cofactor model” of the ...
Michael J. Gaudry, Amanda Bundgaard, Maria Kutschke, Klaudia Ostatek, Margeoux A. S. Dela Rosa, Paul G. Crichton, Jane Reznick, Martin Jastroch   +7 more
wiley   +1 more source