Comparative toxicity of dinophysistoxin-1 and okadaic acid in mice. [PDF]
J Vet Med Sci, 2018 The mouse bioassay for diarrhetic shellfish poisoning toxins has been used worldwide. In this study, dinophysistoxin-1 (DTX-1) and okadaic acid (OA) were compared for toxicity. The lethality rate increased and the median survival time decreased in a dose-dependent manner in both DTX-1 and OA. The median lethal dose value was 150.4 µg/kg (95% confidence
Suzuki H, Okada Y.
europepmc +5 more sources
Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin. [PDF]
Jpn J Cancer Res, 1988 Dinophysistoxin‐1, 35‐methylokadaic acid, is a causative agent of diarrhetic shellfish poisoning. The biological activities and tumor‐promoting activity of dinophysistoxin‐1 were studied together with those of okadaic acid and 7‐O‐palmitoyl okadaic acid.
Fujiki H +9 more
europepmc +5 more sources
Lipophilic Shellfish Poisoning Toxins in Marine Invertebrates from the Galician Coast [PDF]
Toxins, 2023 For the purpose of assessing human health exposure, it is necessary to characterize the toxins present in a given area and their potential impact on commercial species.
Araceli E. Rossignoli +7 more
doaj +2 more sources
Integrated Multi-Omics Analysis Reveals Complex Cytotoxicity-Associated Molecular Response Patterns of Representative Toxins from Four Classes of Lipophilic Algal Toxins in Neuro-2a Cells [PDF]
ToxinsLipophilic marine toxins (LMTs) are important toxic risk factors in marine ecosystems and seafood safety, yet the comparative cytotoxicity-associated molecular responses of different LMT classes remain unclear.
Xueru Wei +5 more
doaj +2 more sources
Co-occurrence of marine and freshwater phycotoxins in oysters, and analysis of possible predictors for management [PDF]
Toxicon: X, 2023 Oysters (Crassostrea virginica) were screened for 12 phycotoxins over two years in nearshore waters to collect baseline phycotoxin data and to determine prevalence of phycotoxin co-occurrence in the commercially and ecologically-relevant species.
Sarah K.D. Pease +12 more
doaj +2 more sources
Oxidative Stress Parameters and Morphological Changes in Japanese Medaka (Oryzias latipes) after Acute Exposure to OA-Group Toxins [PDF]
Life, 2022 Toxins of the OA-group (okadaic acid, OA; dinophysistoxin-1, DTX-1) are the most prevalent in the fjords of southern Chile, and are characterized by their potential harmful effects on aquatic organisms.
Diego Figueroa +5 more
doaj +2 more sources
Toxic Action Reevaluation of Okadaic Acid, Dinophysistoxin-1 and Dinophysistoxin-2: Toxicity Equivalency Factors Based on the Oral Toxicity Study [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Okadaic acid (OA) and the structurally related compounds dinophysistoxin-1 (DTX1) and dinophysistoxin-2 (DTX2) are marine phycotoxins that cause diarrheic shellfish poisoning (DSP) in humans due to ingestion of contaminated shellfish. In
Paula Abal +8 more
doaj +3 more sources
Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1. [PDF]
RSC Adv, 2020 For the first time, the aptamer of dinophysistoxin-1 was successfully obtained with high affinity and specificity by SELEX, and an aptasensor with a detection range from 40 to 600 nM was developed by biolayer interferometry.
Li Z +8 more
europepmc +4 more sources
The Benthic Dinoflagellate Coolia malayensis (Dinophyceae) Produces an Array of Compounds with Antineoplastic Activity in Cells of Tumor Origin [PDF]
Marine DrugsAmong aquatic organisms, marine dinoflagellates are essential sources of bioactive metabolites. The benthic dinoflagellate Coolia malayensis produces metabolites that have exhibited substantial and specific cytotoxicity on cancer cells; however ...
Itzel B. Morales-Montesinos +7 more
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Molecular Responses of Mussel Mytilus galloprovincialis Associated to Accumulation and Depuration of Marine Biotoxins Okadaic Acid and Dinophysistoxin-1 Revealed by Shotgun Proteomics [PDF]
Frontiers in Marine Science, 2020 The molecular pathways behind the toxicity of diarrheic shellfish toxins (DSTs) in bivalves have been scarcely studied. Thus, a shotgun proteomics approach was applied in this work to understand bivalves’ molecular responses to the dinoflagellate ...
José Carlos Martins +10 more
doaj +3 more sources