Results 151 to 160 of about 888 (178)
Some of the next articles are maybe not open access.
Bioorganic & Medicinal Chemistry Letters, 2008
An expedient synthesis of both axially and equatorially C35 methyl substituted spiroketals representing the C28-C38 domain of the potent and selective protein serine/threonine phosphatase inhibitor dinophysistoxin-2 (DTX-2) was developed to enable comparative stereochemical analyses and a stereochemically correct total synthesis of DTX-2. Comparison of
Craig J, Forsyth, Ce, Wang
openaire +2 more sources
An expedient synthesis of both axially and equatorially C35 methyl substituted spiroketals representing the C28-C38 domain of the potent and selective protein serine/threonine phosphatase inhibitor dinophysistoxin-2 (DTX-2) was developed to enable comparative stereochemical analyses and a stereochemically correct total synthesis of DTX-2. Comparison of
Craig J, Forsyth, Ce, Wang
openaire +2 more sources
Toxicon, 1998
The cross-reactivity of the 6/50 monoclonal anti-okadaic acid antibody (mAb) to the recently discovered diarrhetic shellfish poisoning (DSP) metabolites dinophysistoxin-4 (DTX-4), dinophysistoxin-5 (DTX-5), and an okadaic acid (OA) diol ester was determined using a competitive indirect enzyme-linked immunosorbent assay (ELISA).
J E, Lawrence +3 more
openaire +2 more sources
The cross-reactivity of the 6/50 monoclonal anti-okadaic acid antibody (mAb) to the recently discovered diarrhetic shellfish poisoning (DSP) metabolites dinophysistoxin-4 (DTX-4), dinophysistoxin-5 (DTX-5), and an okadaic acid (OA) diol ester was determined using a competitive indirect enzyme-linked immunosorbent assay (ELISA).
J E, Lawrence +3 more
openaire +2 more sources
Esters of okadaic acid and dinophysistoxin-2 in Portuguese bivalves related to human poisonings
Toxicon, 1999Liquid chromatography (HPLC) was used to search for esters of DSP toxins in Portuguese bivalves. Hexane-soluble derivatives of okadaic acid (OA) and dinophysistoxin-2 (DTX-2) were found. Presumably they are acyl derivatives, globally known as 'dinophysistoxin-3' (DTX-3). In certain instances DTX-3 content surpassed 50% of the total amount of DSP toxins.
Paulo Vale, Maria Antónia, M. Sampayo
openaire +2 more sources
Food and Chemical Toxicology, 2017
Ingestion of shellfish with dinophysistoxin-2 (DTX2) can lead to diarrheic shellfish poisoning (DSP). The official control method of DSP toxins in seafood is the liquid chromatography-mass spectrometry analysis (LC-MS). However in order to calculate the total toxicity of shellfish, the concentration of each compound must be multiplied by individual ...
Natalia Vilariño +2 more
exaly +3 more sources
Ingestion of shellfish with dinophysistoxin-2 (DTX2) can lead to diarrheic shellfish poisoning (DSP). The official control method of DSP toxins in seafood is the liquid chromatography-mass spectrometry analysis (LC-MS). However in order to calculate the total toxicity of shellfish, the concentration of each compound must be multiplied by individual ...
Natalia Vilariño +2 more
exaly +3 more sources
Harmful Algae, 2009
Abstract The production of diarrhetic shellfish poisoning toxins (okadaic acid analogues and other lipophilic toxins) by a culture of Dinophysis acuminata, fed with the autotrophic ciliate Myrionecta rubra, was confirmed by LC–MS analysis, and the toxin profile compared with that in the field assemblage of the same species.
Takashi Kamiyama, Toshiyuki Suzuki
openaire +1 more source
Abstract The production of diarrhetic shellfish poisoning toxins (okadaic acid analogues and other lipophilic toxins) by a culture of Dinophysis acuminata, fed with the autotrophic ciliate Myrionecta rubra, was confirmed by LC–MS analysis, and the toxin profile compared with that in the field assemblage of the same species.
Takashi Kamiyama, Toshiyuki Suzuki
openaire +1 more source
Studies on the biosynthesis of the polyether marine toxin dinophysistoxin-1 (DTX-1)
Tetrahedron Letters, 1994Abstract The biosynthetic origin of DTX-1 is establish on the basis of the NMR spectral data of samples obtained by addition of labelled [1- 13 C 1 ], [2- 13 C 1 ] and [1,2- 13 C 2 ] sodium acetate to artificial cultures of the dinoflagellate Prorocentrum lima.
Manuel Norte +2 more
openaire +1 more source
Journal of Chromatography A, 1996
The reagent 9-chloromethylanthracene was evaluated for derivatization of the diarrhetic shellfish poisons, okadaic acid and dinophysistoxin-1 (DTX-1), to form fluorescent products separable by liquid chromatography. The toxins were reacted with the reagent in acetonitrile in the presence of tetramethylammonium hydroxide for 1 h at 90 degrees C.
J F, Lawrence, S, Roussel, C, Ménard
openaire +2 more sources
The reagent 9-chloromethylanthracene was evaluated for derivatization of the diarrhetic shellfish poisons, okadaic acid and dinophysistoxin-1 (DTX-1), to form fluorescent products separable by liquid chromatography. The toxins were reacted with the reagent in acetonitrile in the presence of tetramethylammonium hydroxide for 1 h at 90 degrees C.
J F, Lawrence, S, Roussel, C, Ménard
openaire +2 more sources
Science of The Total Environment, 2020
Diarrhetic shellfish poisoning (DSP) toxins are a class of natural organic contaminants that pose a serious threat not only to marine ecosystems and fisheries but also to human health. They are widely distributed in coastal and offshore waters around the world.
Lei Pan +4 more
openaire +2 more sources
Diarrhetic shellfish poisoning (DSP) toxins are a class of natural organic contaminants that pose a serious threat not only to marine ecosystems and fisheries but also to human health. They are widely distributed in coastal and offshore waters around the world.
Lei Pan +4 more
openaire +2 more sources
Toxicon, 1999
The rare diarrhoeic shellfish poisoning (DSP) toxin, dinophysistoxin-2 (DTX-2), which is an okadaic acid (OA) isomer, has been isolated from a marine phytoplankton biomass that consisted mainly of Dinophysis acuta. Using a large double plankton net (length 5.9 m), bulk phytoplankton samples were collected off the south-west coast of Ireland and ...
K J, James +8 more
openaire +2 more sources
The rare diarrhoeic shellfish poisoning (DSP) toxin, dinophysistoxin-2 (DTX-2), which is an okadaic acid (OA) isomer, has been isolated from a marine phytoplankton biomass that consisted mainly of Dinophysis acuta. Using a large double plankton net (length 5.9 m), bulk phytoplankton samples were collected off the south-west coast of Ireland and ...
K J, James +8 more
openaire +2 more sources
Differential dynamics of dinophysistoxins and pectenotoxins, part II: Offshore bivalve species
Toxicon, 2006Different dinophysistoxin's profiles have been found repeatedly amongst some offshore bivalve molluscs. Species such as the clam, Spisula solida, esterify dinophysistoxins to a great extent, and contain always more okadaic acid (OA) than dinophysistoxin-2 (DTX2).
openaire +2 more sources