Results 171 to 180 of about 4,688 (209)
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Phytotherapy Research
AbstractDiosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other plants. Diosmetin demonstrates a variety of pharmacological activities, including anticancer, antioxidant, anti‐inflammatory, antibacterial, metabolic regulation, cardiovascular function improvement, estrogenic effects, and others.
Xiaofang Li, Jijiao Wu, Zihao Sun
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AbstractDiosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other plants. Diosmetin demonstrates a variety of pharmacological activities, including anticancer, antioxidant, anti‐inflammatory, antibacterial, metabolic regulation, cardiovascular function improvement, estrogenic effects, and others.
Xiaofang Li, Jijiao Wu, Zihao Sun
exaly +3 more sources
Bioactivation of the phytoestrogen diosmetin by CYP1 cytochromes P450
Cancer Letters, 2009Breast cancer is a major cause of death worldwide. Amongst the various forms of treatment chemoprevention is favoured and natural products such as the dietary flavonoids have been examined for their cancer preventative activity. In this study we investigated the anticancer activity of the flavonoid diosmetin, as a result of cytochrome P450 CYP1 ...
Vasilis, Androutsopoulos +3 more
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Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver
Xenobiotica, 19931. The kinetics and metabolism of diosmin and diosmetin were investigated in the isolated perfused rat liver in order to assess the role of the liver. 2. Diosmetin and especially diosmin disappeared quickly from the perfusion medium. 3. Both flavonoids were rapidly metabolized and diosmetin was partly excreted in bile as the glucuronide and sulphate ...
R, Perego +4 more
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Diosmetin inhibits the expression of alpha-hemolysin in Staphylococcus aureus
Antonie van Leeuwenhoek, 2015Staphylococcus aureus is a significant human pathogen that causes a wide range of diseases. Alpha-hemolysin (Hla), a pore-forming cytotoxin that is produced by most S. aureus strains, can cause tissue injury and plays a critical role in the virulence of this pathogen.
Liu, Shui +8 more
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Journal of Food Biochemistry, 2020
The interaction between adipocytes and macrophages in obese tissues plays a critical role in the onset of metabolic syndromes. This study aimed to evaluate the modulatory effect of diosmetin on anti-inflammatory and anti-lipolytic activities in the coculture of macrophages and adipocytes. The secretion of inflammatory mediators increased in a coculture
Hana Lee +4 more
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The interaction between adipocytes and macrophages in obese tissues plays a critical role in the onset of metabolic syndromes. This study aimed to evaluate the modulatory effect of diosmetin on anti-inflammatory and anti-lipolytic activities in the coculture of macrophages and adipocytes. The secretion of inflammatory mediators increased in a coculture
Hana Lee +4 more
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In vivo and in vitro glucuronidation of the flavonoid diosmetin in rats.
Drug Metabolism and Disposition, 1993Flavonoids form an important family of compounds widely present in plants and therefore in food, sometimes as substitutes for synthetic antioxidants. Although the excretion routes of flavonoids in animals has been explored, little is known about the details of their conjugation in the xenobiotic metabolism pathway.
J A, Boutin +6 more
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Vietnam Journal of Chemistry
AbstractThe Diosmetin Phytosome (Dt‐Ph) was developed to enhance the complex's aqueous solubility and in vitro drug release compared to pure Diosmetin (Dt). The process variables such as the reactants’ molar ratio, reaction time, stirring speed, and reaction temperature were varied to identify the most appropriate conditions for synthesis.
Thi‐Kim‐Chi Huynh +11 more
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AbstractThe Diosmetin Phytosome (Dt‐Ph) was developed to enhance the complex's aqueous solubility and in vitro drug release compared to pure Diosmetin (Dt). The process variables such as the reactants’ molar ratio, reaction time, stirring speed, and reaction temperature were varied to identify the most appropriate conditions for synthesis.
Thi‐Kim‐Chi Huynh +11 more
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A validated HPLC determination of the flavone aglycone diosmetin in human plasma
Biomedical Chromatography, 2004AbstractDiosmetin, 3′,5,7‐trihydroxy‐4′‐methoxyflavone, is the aglycone of the flavonoid glycoside diosmin that occurs naturally in foods of plant origin. Diosmin exhibits antioxidant and anti‐inflammatory activities, improves venous tone and it is used for the treatment of chronic venous insufficiency.
Feras Imad, Kanaze +2 more
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Recent Advances in Diosmetin: Pharmacological, Pharmacokinetic, and Toxicological Profile
Current Topics in Medicinal ChemistryDiosmetin, also known as 3´, 5, 7-trihydroxy-4´-methoxyflavone, is a bioflavonoid that can be found in several food sources. These include mainly citrus fruits and plants, such as Rosmarinus officinalis, Citrus sinensis, Galium verum, and Rosa agrestis.
Bhoopendra Singh +2 more
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A toxicological evaluation for safety assessment of ruthenium-based diosmetin complex in rats
Regulatory Toxicology and Pharmacology, 2023The flavonoid-based organometallic complexes have been identified as novel bioactive compounds with enhanced pharmacological and therapeutic activity. In this study, the ruthenium-p-cymene diosmetin complex was synthesized, characterized, and investigated for toxicological profiling through different toxicological and genotoxicological studies which ...
Sidhanta Sil +4 more
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