Results 151 to 160 of about 3,363 (198)
Diosmin mitigates dexamethasone-induced osteoporosis in vivo: Role of Runx2, RANKL/OPG, and oxidative stress [PDF]
Biomedicine and Pharmacotherapy, 2023 Secondary osteoporosis is commonly caused by long-term intake of glucocorticoids (GCs), such as dexamethasone (DEX). Diosmin, a natural substance with potent antioxidant and anti-inflammatory properties, is clinically used for treating some vascular ...
Eglal A Abdelaleem +2 more
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Nutrients, 2017 Diosmin is a nutrient that is widely contained in citrus and that has been indicated to improve glucose metabolism in diabetic disorders. Recently, we demonstrated that diosmin induces β-endorphin to lower hyperglycemia in diabetic rats.
Juei-Tang Cheng +2 more
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Spectroscopic and structural studies of the diosmin monohydrate and anhydrous diosmin
International Journal of Pharmaceutics, 2017Diosmin, a flavone glycoside frequently used in therapy of various veins diseases in monohydrate form, exhibits poor solubility in water and low bioavailability. Due to the fact that the anhydrous forms of drugs generally have better bioavailability than the corresponding hydrates, the aim of this study was to analyze the conversion of diosmin ...
Łukasz Szeleszczuk +3 more
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Diosmin for the prevention of ovarian hyperstimulation syndrome
International Journal of Gynecology & Obstetrics, 2020AbstractObjectiveTo evaluate the effect of oral diosmin on the incidence and severity of ovarian hyperstimulation syndrome (OHSS) and explore the value of diosmin in preventing and treating OHSS.MethodA retrospective study of women attending a reproductive center in Guangzhou, China, between September and December 2016.
Tingting, Li +4 more
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Diosmin pretreatment affects bioavailability of metronidazole
European Journal of Clinical Pharmacology, 2003To screen for inhibitory effects of diosmin on cytochrome P(450)-mediated metabolism of metronidazole in healthy volunteers.Before/after non-blinded investigation conducted in healthy male volunteers.After an overnight fast, metronidazole (two 400-mg tablets) was administered to 12 volunteers, either alone or after a 9-day pretreatment period with a ...
K, Rajnarayana +2 more
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Diosmin-containing phlebotropic drugs in varicose eczema
Angiology and vascular surgery, 2019The purpose of the study was to examine the effect of diosmine-based phlebotropic drugs on dynamics of regress of varicose eczema in patients with chronic venous diseases, to compare their objective complaints and subjective symptoms before and after treatment, to determine the time of improvement.The study enrolled a total of 80 patients presenting ...
D V, Rodnyansky, A A, Fokin
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A pharmacokinetic study of 3H-diosmine.
Arzneimittel-Forschung, 1977A pharmacokinetic study of 3H-labelled 7-rhamnoglycoside of 5,7,3'-trihydroxy-4'-methoxyflavone (3H-diosmine) administered both i.v. and orally, shows the great ease with which it is absorbed in digestion. A very sharp difference in elimination between the two modes of treatment must be associated with a difference in metabolism.
J, Oustrin, M J, Fauran, L, Commanay
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[Studies on pharmacokinetics of diosmin in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008To establish a HPLC method for the determination of diosmin in Rats plasma and to study the pharmacokinetics of diosmin in Rats.Rats were given diosmin with 3 doses as 225, 325, 425 mg x kg(-1). Blood samples were collected at different times after oral administration. The plasma concentration of diosmin was determined by HPLC, and the pharmacokinetics
Ying-Li, Ma, Chao, Ma
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Diosmin: A potential natural drug
Global Journal of Basic ScienceDiosmin is of potential interest for its possible role in human health. Diosmin is a flavone glycoside that is a member of the class of flavonoids, which are secondary metabolites found in large quantities in plants and vegetables. Diosmin is specifically the glycoside of the aglycon diosmetin (3′, 5, 7-trihydroxy-4′-methoxyflavone), which is found ...
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