Results 1 to 10 of about 2,828 (161)

Antihypertensive Effects of Diosmetin in Hypertension-Induced Cardiovascular Abnormalities in Rats [PDF]

Journal of Experimental Pharmacology
Banyaphon Jan-O,1 Metee Iampanichakul,1 Prapassorn Potue,1 Juthamas Khamseekaew,1 Poungrat Pakdeechote,1 Piman Pocasap,2 Parichat Prachaney,3 Anuson Poasakate,4 Putcharawipa Maneesai1 1Department of Physiology, Faculty of Medicine, Khon Kaen University ...
Jan-O B, Iampanichakul M, Potue P, Khamseekaew J, Pakdeechote P, Pocasap P, Prachaney P, Poasakate A, Maneesai P   +8 more
doaj   +4 more sources

Diosmetin Inhibits NETs Formation in Neutrophils Through Regulating Nrf2 Signaling [PDF]

Thoracic Cancer
Background Neutrophil extracellular traps (NETs) are important pieces of equipment for neutrophils. Excess NETs play promoting roles in cancer‐associated thrombosis (CAT).
Lijuan Guo, Hongyang Luo, Yuxin Lei, Leiyan Gu, Yaohui Wang, Siyuan Wang, Zihan Lian, Yuhao Li, Yanlan Xiang, Guanhua Du, Rui Shao, Xiaoxuan Tian, Han Zhang, Linjie Shen, Junli Chen, Yi Wang, Ning Huang, Xiaoyu Niu, Jingyu Li   +18 more
doaj   +4 more sources

Comprehensive review on therapeutic and phytochemical exploration of diosmetin: A promising moiety

Phytomedicine Plus, 2022
Background: Diosmetin is a biologically active flavonoid present mainly in various citrus plants and is known to exhibit wide range of potential in the treatment of various disorders.
Nidhi Garg, Prerna Sarup, Sapna Kumari   +2 more
exaly   +4 more sources

RETRACTED ARTICLE: Identifying therapeutic target for prostate cancer: exploring Diosmetin as a CYP inhibitor

Discover Oncology
Prostate cancer is a prevalent and highly heterogeneous malignancy that affects men globally. Despite the availability of various treatment targets, Cytochrome P450 (CYP) enzymes have gained significant attention due to their crucial role in metabolizing
Mohammad Habibur Rahman Molla, Mohammed Othman Aljahdali   +1 more
doaj   +4 more sources

Investigation into the Antihypertensive Effects of Diosmetin and Its Underlying Vascular Mechanisms Using Rat Model

Pharmaceuticals, 2022
Objective: Diosmetin is a flavonoid that is found in many important medicinal plants that have antihypertensive therapeutic potential. Diosmetin has been shown to have antiplatelet, anti-inflammatory and antioxidant properties, which suggests that it ...
Abdul Jabbar Shāh, Taous Khan, Yusuf S Althobaiti   +2 more
exaly   +3 more sources

Diosmetin Ameliorates Vascular Dysfunction and Remodeling by Modulation of Nrf2/HO-1 and p-JNK/p-NF-κB Expression in Hypertensive Rats

Antioxidants, 2021
Diosmetin is a citrus flavonoid that has antioxidant and anti-inflammatory effects. This study examined the effect of diosmetin on blood pressure and vascular alterations and its underlying mechanisms in experimentally hypertensive rats.
Poungrat Pakdeechote, Sarawoot Bunbupha, Putcharawipa Maneesai   +2 more
exaly   +3 more sources

Diosmetin Alleviates MRSA-Induced Pneumonia in Mice by Inhibiting NLRP3 Inflammasome Activation and NF-κB Signaling Pathway [PDF]

Pharmaceuticals
Background/Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant pathogen that poses a major public health concern.
Chenxi Wu, Huiguo Xie, Xiaofei Liang, Lujie Yang, Zhengxiao Ren, Ping Wu, Yingying Zhang   +6 more
doaj   +2 more sources

Can We Improve Diosmetin Activity? The State-of-the-Art and Promising Research Directions

Molecules, 2023
Diosmetin is a natural substance widely distributed in nature, with documented multidirectional biological effects. The wide spectrum of biological activity of diosmetin gives hope that derivatives of this flavonoid may also be used as drugs or dietary ...
Marcin Feldo, Monika Wujec, Feldo Marcin   +2 more
exaly   +3 more sources

Study on the effect of modified diosmetin for ulcerative colitis. [PDF]

J Mater Sci Mater Med
In recent years, the incidence of ulcerative colitis (UC) has been steadily rising in our country. As a type of inflammatory bowel disease (IBD), UC is primarily characterized by bloody diarrhea, abdominal pain, hematochezia, weight loss, and acute or post-traumatic stress responses.
Liu Y, Wang T, Huang Y, Wang S, Zhou H, He J, Zhang Y, Zhang C, Yang Q, Wang K, Wen X.   +10 more
europepmc   +4 more sources

Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer

Biomedicine and Pharmacotherapy, 2019
Diosmetin is a natural flavonoid obtained from citrus fruits and some medicinal herbs. Previous studies have reported the anti-cancer activity of diosmetin in some types of tumors. However, it is still unclear whether diosmetin exerts anti-cancer effects, particularly anti-angiogenic effects, in skin cancer. In this study, we used B16F10 melanoma cells
Sang-Youel Park
exaly   +3 more sources