Synergistic combinatorial anticancer potential of Tamoxifen with Naringin and Diosmetin in MCF-7 breast cancer cells and their liposomal delivery [PDF]
Scientific ReportsBreast cancer continues to remain a significant issue due to resistance to endocrine therapies, including tamoxifen. Naringin and Diosmetin (natural flavonoids) have anticancer effects that may synergistically enhance therapeutic efficacy when used with ...
Priyanka Uniyal +9 more
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Dunaliella salina-Loaded Diosmetin Carriers Alleviate Oxidative Stress and Inflammation in Cisplatin-Induced Acute Kidney Injury via PI3K/AKT Pathway [PDF]
PharmaceuticsBackground: As a widely used chemotherapeutic agent, cisplatin frequently induces acute kidney injury (AKI), which severely compromises patient survival and limits its clinical use.
Yujing Huangfu +9 more
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Antioxidant Potential of Diosmin and Diosmetin against Oxidative Stress in Endothelial Cells
Molecules, 2022 Phlebotropic flavonoids, including diosmin and its aglycone diosmetin, are natural polyphenols widely used in the prevention and treatment of chronic venous insufficiency (CVI).
Magdalena Wójciak +5 more
doaj +4 more sources
Frontiers in Molecular BiosciencesDiosmin, a flavonoid with documented vascular-protective properties, together with the closely related compounds diosmetin and diosmetin-7-O-glucoside, has not previously been subjected to a systematic comparative biophysical characterization.
Teresa Kaźmierczak +5 more
doaj +3 more sources
Inhibition of Cytochrome P450 2C8-mediated Drug Metabolism by the Flavonoid Diosmetin
Drug Metabolism and Pharmacokinetics, 2011 The aim of this study was to assess the effects of diosmetin and hesperetin, two flavonoids present in various medicinal products, on CYP2C8 activity of human liver microsomes using paclitaxel oxidation to 6α-hydroxy-paclitaxel as a probe reaction. Diosmetin and hesperetin inhibited 6α-hydroxy-paclitaxel production in a concentration-dependent manner ...
Luigi Quintieri +2 more
exaly +3 more sources
The Molecular Pathways of Diosmetin: A Flavonoid’s Role in Preventing Chronic Diseases
Allied Medical Research JournalDiosmetin is a flavonoid predominantly found in citrus fruits that has recently attracted research interest as a potential candidate for preventing chronic diseases such as diabetes, cardiovascular diseases, neurodegeneration, and inflammation.
Saviya Kashif, Abdul Hameed
doaj +2 more sources
Flavonoid Inhibition of Bacillus licheniformis LP-8 Lipase: In Vitro and In Silico Insights Into Anti-Obesity Potential. [PDF]
ChemistryOpenBacillus licheniformis LP‐8, isolated from hot spring, produced lipase using waste frying oil. Flavonoids inhibited enzyme activity, confirmed by reduced activity assays. Molecular docking revealed hydrogen‐bond interactions within the lipase active site.
Bayrak S, Omeroglu MA, Senol H.
europepmc +2 more sources
Potential pharmacological mechanism of Colitis treatment by diosmetin [PDF]
, 2020 BACKGROUND AND PURPOSE Diosmetin exhibits a series of therapeutic efficacy but little is known of its effects on colitis. EXPERIMENTAL APPROACH In this study, two mouse models of DSS (the concentration of 3% and 5%)-induced colitis and Caco2 and IEC-6 cells were employed.
hailong Li +11 more
openaire +2 more sources
Dermatologica Sinica, 2022 Background: Psoriasis is a common skin inflammatory disease. Dysregulated growth and differentiation of keratinocytes are the main characteristics of psoriasis.
Jinyan Yang +6 more
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Biological Research, 2021 Background Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical treatment, remained unknown.
Rende Ning +5 more
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