Results 11 to 20 of about 4,688 (209)

Dunaliella salina-Loaded Diosmetin Carriers Alleviate Oxidative Stress and Inflammation in Cisplatin-Induced Acute Kidney Injury via PI3K/AKT Pathway [PDF]

Pharmaceutics
Background: As a widely used chemotherapeutic agent, cisplatin frequently induces acute kidney injury (AKI), which severely compromises patient survival and limits its clinical use.
Yujing Huangfu, Wei Chen, Dandan Guo, Peiyao Wang, Aifang Li, Yi Yang, Shuxuan Li, Qianfang Wang, Baiyan Wang, Shuying Feng   +9 more
doaj   +2 more sources

Synergistic combinatorial anticancer potential of Tamoxifen with Naringin and Diosmetin in MCF-7 breast cancer cells and their liposomal delivery [PDF]

Scientific Reports
Breast cancer continues to remain a significant issue due to resistance to endocrine therapies, including tamoxifen. Naringin and Diosmetin (natural flavonoids) have anticancer effects that may synergistically enhance therapeutic efficacy when used with ...
Priyanka Uniyal, Siddhartha Das Pramanik, Swadha Pandey, Prashant Shukla, Partha Roy, Deepak Parashar, Saurabh Gupta, Ravi Rawat, Anand Gaurav, Vannajan Sanghiran Lee   +9 more
doaj   +2 more sources

Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer

Biomedicine and Pharmacotherapy, 2019
Diosmetin is a natural flavonoid obtained from citrus fruits and some medicinal herbs. Previous studies have reported the anti-cancer activity of diosmetin in some types of tumors. However, it is still unclear whether diosmetin exerts anti-cancer effects, particularly anti-angiogenic effects, in skin cancer. In this study, we used B16F10 melanoma cells
Jawun Choi, Sang-Youel Park
exaly   +3 more sources

Tailored biosynthesis of diosmin through reconstitution of the flavonoid pathway in Nicotiana benthamiana [PDF]

Frontiers in Plant Science
The flavonoid diosmin (diosmetin 7-O-rutinoside) is used as a therapeutic agent for disorders of the blood vessels such as hemorrhoids and varicose veins. Diosmin is commercially produced using semi-synthetic methods involving the oxidation of hesperidin,
Hyo Lee, Sangkyu Park, Saet Buyl Lee, Jaeeun Song, Tae-Hwan Kim, Beom-Gi Kim   +5 more
doaj   +2 more sources

The Molecular Pathways of Diosmetin: A Flavonoid’s Role in Preventing Chronic Diseases

Allied Medical Research Journal
Diosmetin is a flavonoid predominantly found in citrus fruits that has recently attracted research interest as a potential candidate for preventing chronic diseases such as diabetes, cardiovascular diseases, neurodegeneration, and inflammation.
Saviya Kashif, Abdul Hameed
doaj   +2 more sources

Immunomodulatory Mechanism of Baiyaojian Decoction on Periodontitis: Network Pharmacology, Single-Cell RNA Sequencing and Molecular Docking. [PDF]

J Cell Mol Med
ABSTRACT Periodontitis is one of the most common oral inflammatory diseases. Baiyaojian decoction, known for its prominent immunomodulatory and anti‐inflammatory properties, shows significant potential in treating periodontitis, though its molecular mechanisms remain unknown. The active ingredients and therapeutic targets were determined by integrating
Chen BJ, Li MM, Zheng ZY, Jin WQ, Jin Z, Zuo YL.   +5 more
europepmc   +2 more sources

Diosmetin ameliorates imiquimod-induced psoriasis by regulating apoptosis and inflammation via toll-like receptor 4/nuclear factor kappa B pathway

Dermatologica Sinica, 2022
Background: Psoriasis is a common skin inflammatory disease. Dysregulated growth and differentiation of keratinocytes are the main characteristics of psoriasis.
Jinyan Yang, Mingfeng Zhan, Zhaohui Chen, Lihua Li, Juan Lu, Min Yang, Xuewen Gao   +6 more
doaj   +1 more source

Chemical Constituents and Biological Potentials of Teucrium scordium subsp. scordioides Extracts: In Vitro Experimental and In Silico Perspectives. [PDF]

ChemistryOpen
T. scordium subsp. scordioides may represent a natural source of antioxidants and enzyme inhibitors for use in different health‐promoting formulations. This study was undertaken to examine, for the first time, the antioxidant and enzyme inhibitory properties of several extracts obtained from the aerial parts of Teucrium scordium subsp.
Akgul BH, Yagi S, Cetiz MV, Saka E, Zengin G, Llorent-Martínez EJ, Gómez-Torres M, Yapıcı I, Gulcin I, Yıldıztugay E.   +9 more
europepmc   +2 more sources

Potential pharmacological mechanism of Colitis treatment by diosmetin [PDF]

, 2020
BACKGROUND AND PURPOSE Diosmetin exhibits a series of therapeutic efficacy but little is known of its effects on colitis. EXPERIMENTAL APPROACH In this study, two mouse models of DSS (the concentration of 3% and 5%)-induced colitis and Caco2 and IEC-6 cells were employed.
hailong Li, Yiying Wei, Xiaohe Li, Shanshan Zhang, Ruotong Zhang, jinhe Li, Bowei Ma, Shuaibo Shao, Ziwei Lv, hao Ruan, Honggang Zhou, Cheng Yang   +11 more
openaire   +2 more sources

Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc signaling pathway in human osteosarcoma cells

Biological Research, 2021
Background Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical treatment, remained unknown.
Rende Ning, Guang Chen, Run Fang, Yanhui Zhang, Wenjuan Zhao, Feng Qian   +5 more
doaj   +1 more source