Results 21 to 30 of about 4,688 (209)

Characterisation, development and validation of UV Spectrophotometric technique for determining Diosmetin in bulk and nanoformulations

Results in Chemistry, 2023
Background: From ancient times, India and many other countries have utilised natural products to manage various illnesses. Because they are abundantly available and have fewer adverse effects than synthetic medications, flavonoids are secondary ...
Sumit Sheoran, Swati Arora, Himanshu Singh, Anupam Kumar, Sugunakar Vuree, Harish Vancha, Smita C Pawar   +6 more
doaj   +1 more source

Binding and antiplatelet activity of quercetin, rutin, diosmetin, and diosmin flavonoids

Biomedicine & Pharmacotherapy, 2021
Platelets exert an essential role in vascular inflammation and thrombosis. Flavonoids are natural compounds employed for the clinical management of vascular disorders preventing capillary permeability, working as phlebotonics and improving the blood rheology, although their mechanism of action remains partially unknown. The effects of quercetin, rutin,
Zaragozá Arnáez, Cristina, Álvarez de Mon Soto, Melchor, Monserrat Sanz, Jorge, Mantecón Ramiro, Carolina, Villaescusa Castillo, Lucinda, Álvarez de Mon González, Miguel Ángel, Zaragoza García, Francisco   +6 more
openaire   +2 more sources

Diosmetin attenuate experimental ulcerative colitis in rats via suppression of NF-κB, TNF-α and IL-6 signalling pathways correlated with down-regulation of apoptotic events

European Journal of Inflammation, 2021
Introduction Ulcerative colitis (UC) is a chronic inflammation of colon in which the innermost tissue of colon and rectum develops deep-rooted inflammation.
Xiaoyan Yu, Yang Liu
doaj   +1 more source

Investigation into the in vivo mechanism of diosmetin in patients with breast cancer and COVID-19 using bioinformatics

Frontiers in Pharmacology, 2022
Patients with breast cancer are prone to SARS-CoV-2 infection [the causative virus of coronavirus disease (COVID-19)] due to their lack of immunity.
Jin Wang, Shanbo Ma, Long Li, Yuhan Chen, Yuhan Chen, Qian Yang, Feiyan Wang, Feiyan Wang, Meiling Zheng, Meiling Zheng, Shan Miao, Xiaopeng Shi   +11 more
doaj   +1 more source

Effect of Date Palm (Phoenix dactylifera) Phytochemicals on Aβ1−40 Amyloid Formation: An in-silico Analysis

Frontiers in Neuroscience, 2022
Alzheimer's disease (AD) is a neurodegenerative disease and the most prevalent form of dementia. The generation of oxygen free radicals and oxidative damage is believed to be involved in the pathogenesis of AD.
Qamar Zia, Qamar Zia, Md Tabish Rehman, Md Amiruddin Hashmi, Sahabjada Siddiqui, Abdulaziz Bin Dukhyil, Mohammad Z. Ahmed, Azfar Jamal, Azfar Jamal, Saeed Banawas, Saeed Banawas, Saeed Banawas, Sami G. Almalki, Mohammad Owais, Hamad Qasem Aldhafeeri, Ibrahim M. Ibrahim, Wael Alturaiki, Mohamed F. AlAjmi, Mohammed Alsieni, Yaser E. Alqurashi   +19 more
doaj   +1 more source

The Antioxidative Effects of Flavones in Hypertensive Disease

Biomedicines, 2023
Hypertension is the leading remediable risk factor for cardiovascular morbidity and mortality in the United States. Excess dietary salt consumption, which is a catalyst of hypertension, initiates an inflammatory cascade via activation of antigen ...
Alexandria Porcia Haynes, Selam Desta, Taseer Ahmad, Kit Neikirk, Antentor Hinton, Nathaniel Bloodworth, Annet Kirabo   +6 more
doaj   +1 more source

Diosmetin Affects Gene Expression on Human Lung Adenocarcinoma Cells

Journal of Oncology, 2022
Objective. This study was aimed at investigating the effects of diosmetin (a natural flavonoid) on the gene expression of human lung adenocarcinoma (LUAD) cells. Methods. HCC827 and A549 cells were used. MTT and colony formation assay were used to investigate the effects of diosmetin on cell proliferation and colony forming activity.
Changshan Song, Shunfu Deng, Hui Hu, Zheng Zheng, Bairu Shen, Xuhui Wu, Minqian Huang, Jiaqing Wang, Zhenyu Wang   +8 more
openaire   +2 more sources

Anti-Inflammatory and Antioxidant Effects of Diosmetin-3-O-β-d-Glucuronide, the Main Metabolite of Diosmin: Evidence from Ex Vivo Human Skin Models

Molecules, 2023
Diosmin is used to relieve chronic venous disease (CVD) symptoms. This study aimed to investigate the anti-inflammatory and antioxidant effects of diosmetin-3-O-β-d-glucuronide, the major metabolite of diosmin, using human skin explants.
Sylvie Boisnic, Marie-Christine Branchet, Barbara Quioc-Salomon, Julie Doan, Catherine Delva, Célia Gendron   +5 more
doaj   +1 more source

Antioxidant Flavonoid Diosmetin Is Cardioprotective in a Rat Model of Myocardial Infarction Induced by Beta 1-Adrenergic Receptors Activation

Current Issues in Molecular Biology, 2023
Myocardial infarction (MI) is a common and life-threatening manifestation of ischemic heart diseases (IHD). The most important risk factor for MI is hypertension.
Taseer Ahmad, Taous Khan, Annet Kirabo, Abdul Jabbar Shah   +3 more
doaj   +1 more source

Co-Encapsulation of Curcumin and Diosmetin in Nanoparticles Formed by Plant-Food-Protein Interaction Using a pH-Driven Method

Foods, 2023
In this work, a pH-driven method was used to prepare zein–soy protein isolate (SPI) composite nanoparticles (NPs). The mass ratio of SPI to zein influenced the Z-average size (Z-ave).
Chong Yu, Jingyu Shan, Ze Fu, Hao Ju, Xiao Chen, Guangsen Xu, Yang Liu, Huijing Li, Yanchao Wu   +8 more
doaj   +1 more source