Results 41 to 50 of about 2,828 (161)

Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer [PDF]

Cell Cycle, 2020
Radiotherapy is an essential treatment for endometrial cancer (EC), especially in advanced, metastatic, and recurrent cases. Combining radiotherapy, which mainly causes DNA double-strand breaks (DSBs), with small molecules targeting aberrantly activated homologous recombination (HR) repair pathways holds great potential for treating ECs in advanced ...
Zhiyi, Hu, Bailian, Cai, Mengfei, Wang, Xiaoli, Wen, Anke, Geng, Xiang, Hu, Renhao, Xue, Zhiyong, Mao, Ying, Jiang, Xiaoping, Wan   +9 more
openaire   +2 more sources

Diosmetin inhibits apoptosis and activates AMPK‐induced autophagy in myocardial damage under hypoxia environment

Kaohsiung Journal of Medical Sciences, 2022
Inhibition of hypoxia‐induced cardiomyocyte apoptosis is considered as an important treatment method for ischemic heart diseases, but related drugs are still insufficient. The present study aims to explore the protective function and mechanism of the key
Wen‐Shuai He, Yun Wu, Mao‐Jia Ren, Zhong‐Yu Yu, Xing‐Sheng Zhao   +4 more
doaj   +1 more source

Inhibition of TGF-β Signaling in Gliomas by the Flavonoid Diosmetin Isolated from Dracocephalum peregrinum L.

Molecules, 2020
Background: Dracocephalum peregrinum L., a traditional Kazakh medicine, has good expectorant, anti-cough, and to some degree, anti-asthmatic effects. Diosmetin (3′,5,7-trihydroxy-4′-methoxyflavone), a natural flavonoid found in traditional ...
Yuli Yan, Xingyu Liu, Jie Gao, Yin Wu, Yuxin Li   +4 more
doaj   +1 more source

Impact of Yarrow Phenolic Compounds on the Composition, Structure, and Thermal Properties of Lupin Protein‐Stabilized Oil‐in‐Water Nanoemulsions

Sustainable Food Proteins, Volume 4, Issue 3, September 2026.
Yarrow phenolics modulate the interfacial and thermal behavior of lupin protein‐stabilized nanoemulsions through noncovalent interactions, altering droplet size, viscoelastic properties, and protein structure. ABSTRACT The effect of phenolic compounds extracted from yarrow (Achillea millefolium L.) in the interfacial stabilization of oil–water ...
María de las Nieves Siles‐Sánchez, Laura Jaime, Susana Santoyo, Milena Corredig   +3 more
wiley   +1 more source

Inhibition of c-Kit signaling by diosmetin isolated from Chrysanthemum morifolium [PDF]

Archives of Pharmacal Research, 2013
The interaction of stem cell factor (SCF) with its cognate receptor c-Kit is closely associated with the survival and maturation of melanocytes. To investigate novel depigmentation agents, we screened 2,000 plant extracts for c-Kit inhibitors to identify active small molecules by using time-resolved fluorescence enzyme assays.
Lee, Seong Jin, Jung, Tae-Hoon, Kim, Hojeong, Jeong, Daeyoung, Choi, Gildon, Park, Woo-Kyu, Kong, Jae Yang, Jin, Mu-Hyun, Cho, Heeyeong   +8 more
openaire   +2 more sources

From Metabolites to Mechanisms: Scorzonera parviflora Aerial Parts and Roots Extracts Profiled by UPLC‐ESI‐MS/MS, In Vitro/In Silico Tests, and Network Analysis

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Scorzonera parviflora is considered a promising candidate for applications in the pharmaceutical, nutraceutical, and natural product industries. ABSTRACT In the present study, the extraction of Scorzonera parviflora aerial parts and roots was performed using four solvents, namely ethyl acetate (EA), ethanol, ethanol/water, and water. The total phenolic
Gokhan Zengin, Nilofar Nilofar, Gunes Ak, Eliana Fernandes, Luísa Custódio, Maria João Rodrigues, Shaza Aly, Omayma A. Eldahshan, Abdel Nasser Singab, Evren Yildiztugay, Milena Terzic, Meng‐Yao Li   +11 more
wiley   +1 more source

Role and possible mechanism of diosmetin in alleviating nephritis response in MRL/lpr lupus nephritis mice

陆军军医大学学报, 2022
Objective To investigate the protective effect of diosmetin on lupus nephritis and its possible mechanism. Methods Ten C57BL/6 mice were used as control group, and 50 MRL/lpr lupus mice were randomly divided into MRL/lpr group, dexamethasone group, and 3
XU Mengxia, HUANG Zhongming, TANG Hongying, TANG Ling, YANG Haiyan   +4 more
doaj   +1 more source

Microbiota‐Targeted Chitooligosaccharides Intervention Restores Glucose Homeostasis After Islet Cell Transplantation in Rapamycin‐Treated Mice

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Gut microbiota from islet cell transplantation patients treated with rapamycin significantly elevated blood glucose levels in recipient mice. Chitooligosaccharides improved rapamycin‐induced gut dysbiosis and islet dysfunction in human microbiota‐associated T2DM mice.
Kunlin Chang, Duowen He, Junfeng Dong, Yayu Zhang, Shuxin Deng, Mengyao Zhao, Jiayang Jin, Xiaoguo Ji, Hao Yin, Liming Zhao   +9 more
wiley   +1 more source

Diosmetin ameliorates osteoarthritic inflammation in vivo and ECM macromolecules degradation in interleukin-1β-stimulated murine chondrocytes through the Nrf2/NF-κB pathway

Folia Histochemica et Cytobiologica
INTRODUCTION: Osteoarthritis (OA) is a prevailing degenerative disease in elderly population and can lead to severe joint dysfunction. Studies have revealed various pharmacological activities of diosmetin, including the anti-OA efficacy.
Liang Qian, Chuang Li, Hong Liu, Hui Zhou, Tao Tan   +4 more
doaj   +1 more source

Recent Advances in the Use of Natural Deep Eutectic Solvents for Natural Product Sample Preparation: Focus on Purification, Characterization, and Sustainability

Journal of Separation Science, Volume 49, Issue 7, July 2026.
ABSTRACT This review examines recent advances in the use of natural deep eutectic solvents (NaDES) for natural product sample preparation, with emphasis on extraction, purification, analytical compatibility, and sustainability. NaDES emerge as versatile, tunable, and biocompatible media that enhance the recovery and stability of diverse phytochemicals ...
Valeria Cedeño‐Fierro, Juan Felipe Grisales‐Mejía, Harlen Gerardo Torres Castañeda, Jose A. Mendiola   +3 more
wiley   +1 more source