Results 31 to 40 of about 2,828 (161)

Co-Encapsulation of Curcumin and Diosmetin in Nanoparticles Formed by Plant-Food-Protein Interaction Using a pH-Driven Method

Foods, 2023
In this work, a pH-driven method was used to prepare zein–soy protein isolate (SPI) composite nanoparticles (NPs). The mass ratio of SPI to zein influenced the Z-average size (Z-ave).
Chong Yu, Jingyu Shan, Ze Fu, Hao Ju, Xiao Chen, Guangsen Xu, Yang Liu, Huijing Li, Yanchao Wu   +8 more
doaj   +1 more source

Flavonoids and fibrate modulate apoE4-induced processing of amyloid precursor protein in neuroblastoma cells

Frontiers in Neuroscience, 2023
IntroductionApolipoprotein (apo) E4, being a major genetic risk factor for Alzheimer’s disease (AD), is actively involved in the proteolytic processing of amyloid precursor protein (APP) to amyloid β (Aβ) peptide, the principle constituent of amyloid ...
Viralkumar Davra, Kenza E. Benzeroual
doaj   +1 more source

Physicochemical Properties of Diosmetin and Lecithin Complex

Tropical Journal of Pharmaceutical Research, 2013
Purpose: To improve the hydrophobicity of diosmetin, the complex of diosmetin and lecithin was prepared and its physicochemical properties were characterized in this study.Methods: The complex of diosmetin and lecithin was prepared by solvent method. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry(UV ...
Brad, Korbanjhon, Chen, Chungang
openaire   +3 more sources

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum. [PDF]

Plant Biotechnol J
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Zhang Q, Wu Q, Shi W, Deng Y, Zhan R, Ma D.   +5 more
europepmc   +2 more sources

Effect of diosmetin on airway remodeling in a murine model of chronic asthma [PDF]

Acta Biochimica et Biophysica Sinica, 2015
Bronchial asthma, one of the most common allergic diseases, is characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. The anti-oxidant flavone aglycone diosmetin ameliorates the inflammation in pancreatitis, but little is known about its impact on asthma.
Ai, Ge, Yanan, Liu, Xiaoning, Zeng, Hui, Kong, Yuan, Ma, Jiaxiang, Zhang, Fangfang, Bai, Mao, Huang   +7 more
openaire   +2 more sources

Diosmetin Exerts Synergistic Effects in Combination with 5-Fluorouracil in Colorectal Cancer Cells

Biomedicines, 2022
5-Fluorouracil (5-FU) is a chemotherapeutic medication commonly used to treat colorectal cancer (CRC); however, the drug-associated adverse effects and toxicity have greatly affected its clinical use.
Sareh Kamran, Ajantha Sinniah, Zamri Chik, Mohammed Abdullah Alshawsh   +3 more
doaj   +1 more source

Effect of diosmetin on proliferation, apoptosis and migration of colorectal cancer cells by regulating STX17-AS1/miR-383-5p axis

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect of diosmetin on the proliferation, apoptosis and migration of colorectal cancer cells, and further to analyze whether its mechanism is related to the regulation of STX17-AS1/miR-383-5p axis.
WU Yuan, LIU Jiyu, ZHANG Qin
doaj   +1 more source

Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells.

PLoS ONE, 2016
This study aimed to determine the reaction kinetics of the regioselective glucuronidation of diosmetin and chrysoeriol, two important methylated metabolites of luteolin, by human liver microsomes (HLMs) and uridine-5'-diphosphate glucuronosyltransferase (
Xuejun Zeng, Jian Shi, Min Zhao, Qingwei Chen, Liping Wang, Huangyu Jiang, Feifei Luo, Lijun Zhu, Linlin Lu, Xinchun Wang, Zhongqiu Liu   +10 more
doaj   +1 more source

Design of an Herbal Preparation Composed by a Combination of Ruscus aculeatus L. and Vitis vinifera L. Extracts, Magnolol and Diosmetin to Address Chronic Venous Diseases through an Anti-Inflammatory Effect and AP-1 Modulation

Plants, 2023
Chronic venous disease (CVD) is an often underestimated inflammatory pathological condition that can have a serious impact on quality of life. Many therapies have been proposed to deal with CVD, but unfortunately the symptoms recur with increasing ...
Raffaella Nocera, Daniela Eletto, Valentina Santoro, Valentina Parisi, Maria Laura Bellone, Marcello Izzo, Alessandra Tosco, Fabrizio Dal Piaz, Giuliana Donadio, Nunziatina De Tommasi   +9 more
doaj   +1 more source

Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide

Molecules, 2022
Diosmin is widely used as a venoactive drug in the pharmacological treatment of chronic venous disorders. It exerts a strong protective effect on blood vessels via an increase in the elasticity of vessel walls and reduces the permeability of capillary ...
Marcin Feldo, Magdalena Wójciak, Aleksandra Ziemlewska, Sławomir Dresler, Ireneusz Sowa   +4 more
doaj   +1 more source