Results 11 to 20 of about 14,175 (245)

Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases

Nature Communications, 2022
Kleiner and co-workers profile RNA 5-methylcytidine (m5C) dioxygenase enzymes using an activity-based metabolic probing strategy. They reveal ALKBH1 as the major 5-formylcytidine (f5C) writer and characterize modification sites across mRNA and tRNA.
A. Emilia Arguello, Ang Li, Xuemeng Sun, Tanner W. Eggert, Elisabeth Mairhofer, Ralph E. Kleiner   +5 more
doaj   +1 more source

Biocatalyst Screening with a Twist: Application of Oxygen Sensors Integrated in Microchannels for Screening Whole Cell Biocatalyst Variants

Bioengineering, 2018
Selective oxidative functionalization of molecules is a highly relevant and often demanding reaction in organic chemistry. The use of biocatalysts allows the stereo- and regioselective introduction of oxygen molecules in organic compounds at milder ...
Ana C. Fernandes, Julia M. Halder, Bettina M. Nestl, Bernhard Hauer, Krist V. Gernaey, Ulrich Krühne   +5 more
doaj   +1 more source

2-oxoglutarate-dependent dioxygenases: A renaissance in attention for ascorbic acid in plants.

PLoS ONE, 2020
L-Ascorbic acid (ascorbate, Vitamin C) is an essential human micronutrient that is predominantly obtained from plants. It is known to work as the major antioxidant in plants, and it underpins several environmentally induced stresses due to its use as a ...
Asaad M Mahmood, Jim M Dunwell
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Indoleamine 2,3-dioxygenase vaccination [PDF]

OncoImmunology, 2015
Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. Remarkably, we discovered IDO-specific T cells that can influence adaptive immune reactions in patients with cancer. Further, a recent phase I clinical trial demonstrated long-lasting disease stabilization without toxicity in patients with non-small-cell lung cancer (NSCLC) who were ...
Andersen, Mads Hald, Svane, Inge Marie
openaire   +3 more sources

Hydroperoxylation by Hydroxyethylphosphonate Dioxygenase [PDF]

Journal of the American Chemical Society, 2009
Hydroxyethylphosphonate dioxygenase (HEPD) catalyzes the O(2)-dependent cleavage of the carbon-carbon bond of 2-hydroxyethylphosphonate (2-HEP) to afford hydroxymethylphosphonate (HMP) and formate without input of electrons or use of any organic cofactors. Two mechanisms have been proposed to account for this reaction.
Whitteck, John T., Cicchillo, Robert M., Donk, Wilfred A. van der   +2 more
openaire   +2 more sources

Genome-wide identification and in-silico expression analysis of carotenoid cleavage oxygenases gene family in Oryza sativa (rice) in response to abiotic stress

Frontiers in Plant Science, 2023
Rice constitutes a foundational cereal and plays a vital role in the culinary sector. However, the detriments of abiotic stress on rice quality and productivity are noteworthy. Carotenoid cleavage oxygenases (CCO) hold vital importance as they enable the
Muhammad Zeshan Haider, Adnan Sami, Muhammad Shafiq, Waheed Anwar, Sajid Ali, Qurban Ali, Sher Muhammad, Irfan Manzoor, Muhammad Adnan Shahid, Daoud Ali, Saud Alarifi   +10 more
doaj   +1 more source

Substrate stereo‐specificity in tryptophan dioxygenase and indoleamine 2,3‐dioxygenase [PDF]

Proteins: Structure, Function, and Bioinformatics, 2010
AbstractThe first and rate‐limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to N‐formylkynurenine is catalyzed by two heme‐containing proteins, Indoleamine 2,3‐dioxygenase (IDO), and Tryptophan 2,3‐dioxygenase (TDO). In mammals, TDO is found exclusively in liver tissue, IDO is found ubiquitously in all tissues.
Luciana, Capece, Mehrnoosh, Arrar, Adrian E, Roitberg, Syun-Ru, Yeh, Marcelo A, Marti, Dario A, Estrin   +5 more
openaire   +2 more sources

Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3

Nature Communications, 2022
Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.
Romain O. Georges, Hugo Sepulveda, J. Carlos Angel, Eric Johnson, Susan Palomino, Roberta B. Nowak, Arshad Desai, Isaac F. López-Moyado, Anjana Rao   +8 more
doaj   +1 more source

Structure of an aromatic-ring-hydroxylating dioxygenase – naphthalene 1,2-dioxygenase [PDF]

Structure, 1998
Pseudomonas sp. NCIB 9816-4 utilizes a multicomponent enzyme system to oxidize naphthalene to (+)-cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The enzyme component catalyzing this reaction, naphthalene 1,2-dioxygenase (NDO), belongs to a family of aromatic-ring-hydroxylating dioxygenases that oxidize aromatic hydrocarbons and related compounds to cis ...
Kauppi, Björn, Lee, Kyoung, Carredano, Enrique, Parales, Rebecca E, Gibson, David T, Eklund, Hans, Ramaswamy, S   +6 more
openaire   +2 more sources