The Contribution of Plant Dioxygenases to Hypoxia Signaling
Frontiers in Plant Science, 2020 Dioxygenases catalyze the incorporation of one or two oxygen atoms into target organic substrates. Besides their metabolic role, these enzymes are involved in plant signaling pathways as this reaction is in several instances required for hormone ...
Sergio Iacopino +5 more
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Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness. [PDF]
, 2014 Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1α, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).
Huang, Lan +5 more
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Further studies on the substrate spectrum of phytanoyl-CoA hydroxylase
Journal of Lipid Research, 2003 Refsum disease is a peroxisomal disorder characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy, ataxia, and an accumulation of phytanic acid in plasma and tissues.
Veerle Foulon +5 more
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Structure and function prediction of human homologue hABH5 of _E. coli_ ALKB5 using in silico approach [PDF]
, 2011 Newly discovered human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Little is known about the structure and function of hABH5, one of the members of this superfamily.
Ambarish Sharan Vidyarthi +2 more
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Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB
BMC Genomics, 2003 Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz +3 more
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Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases
Nature Communications, 2022 Kleiner and co-workers profile RNA 5-methylcytidine (m5C) dioxygenase enzymes using an activity-based metabolic probing strategy. They reveal ALKBH1 as the major 5-formylcytidine (f5C) writer and characterize modification sites across mRNA and tRNA.
A. Emilia Arguello +5 more
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Dioxygen Reactivity of Biomimetic Fe(II) Complexes with Noninnocent Catecholate, \u3cem\u3eo\u3c/em\u3e-Aminophenolate, and \u3cem\u3eo\u3c/em\u3e-Phenylenediamine Ligands [PDF]
, 2014 This study describes the O2 reactivity of a series of high-spin mononuclear Fe(II) complexes each containing the facially coordinating tris(4,5-diphenyl-1-methylimidazol-2-yl)phosphine (Ph2TIP) ligand and one of the following bidentate, redox-active ...
Bittner, Michael M. +3 more
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Bioengineering, 2018 Selective oxidative functionalization of molecules is a highly relevant and often demanding reaction in organic chemistry. The use of biocatalysts allows the stereo- and regioselective introduction of oxygen molecules in organic compounds at milder ...
Ana C. Fernandes +5 more
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Inhibition of DNA methyltransferase leads to increased genomic 5-hydroxymethylcytosine levels in hematopoietic cells. [PDF]
, 2018 5-Hydroxymethylcytosine (5hmC) is produced from 5-methylcytosine (5mC) by Ten-eleven translocation (TET) dioxygenases. The epigenetic modification 5hmC has crucial roles in both cellular development and differentiation.
Apró, Anna +9 more
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2-oxoglutarate-dependent dioxygenases: A renaissance in attention for ascorbic acid in plants.
PLoS ONE, 2020 L-Ascorbic acid (ascorbate, Vitamin C) is an essential human micronutrient that is predominantly obtained from plants. It is known to work as the major antioxidant in plants, and it underpins several environmentally induced stresses due to its use as a ...
Asaad M Mahmood, Jim M Dunwell
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