Results 21 to 30 of about 25,696 (256)
Cancer Cell, 2011 SUMMARY IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and 2-hydroxyglutarate (2-HG), respectively.
W. Xu +21 more
semanticscholar +1 more source
Cofactor Generation Cascade for α-Ketoglutarate and Fe(II)-Dependent Dioxygenases
ACS Sustainable Chemistry and Engineering, 2020 Fe(II)- and α-ketoglutarate dependent dioxygenases have emerged as important catalysts for the preparation of non-natural amino acids. The stoichiometric supply of the cosubstrate α-ketoglutarate (αKG) is an important cost factor.
F. Busch +4 more
semanticscholar +1 more source
Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB
BMC Genomics, 2003 Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz +3 more
doaj +1 more source
Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases
Nature Communications, 2022 Kleiner and co-workers profile RNA 5-methylcytidine (m5C) dioxygenase enzymes using an activity-based metabolic probing strategy. They reveal ALKBH1 as the major 5-formylcytidine (f5C) writer and characterize modification sites across mRNA and tRNA.
A. Emilia Arguello +5 more
doaj +1 more source
Bioengineering, 2018 Selective oxidative functionalization of molecules is a highly relevant and often demanding reaction in organic chemistry. The use of biocatalysts allows the stereo- and regioselective introduction of oxygen molecules in organic compounds at milder ...
Ana C. Fernandes +5 more
doaj +1 more source
Nonheme Iron- and 2-Oxoglutarate-Dependent Dioxygenases in Fungal Meroterpenoid Biosynthesis.
Chemical and pharmaceutical bulletin, 2020 This review summarizes the recent progress in research on the non-heme Fe(II)- and 2-oxoglutarate-dependent dioxygenases, which are involved in the biosynthesis of pharmaceutically important fungal meroterpenoids.
I. Abe
semanticscholar +1 more source
2-oxoglutarate-dependent dioxygenases: A renaissance in attention for ascorbic acid in plants.
PLoS ONE, 2020 L-Ascorbic acid (ascorbate, Vitamin C) is an essential human micronutrient that is predominantly obtained from plants. It is known to work as the major antioxidant in plants, and it underpins several environmentally induced stresses due to its use as a ...
Asaad M Mahmood, Jim M Dunwell
doaj +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases.
DNA Repair, 2020 Iron-dependent dioxygenases of the AlkB protein family found in most organisms throughout the tree of life play a major role in oxidative dealkylation processes.
V. van Deuren, S. Plessers, J. Robben
semanticscholar +1 more source
Nature Communications, 2022 Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.
Romain O. Georges +8 more
doaj +1 more source