Results 11 to 20 of about 14,709 (260)
Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation
IUCrJ, 2014 Iron(II) and 2-oxoglutarate (2OG)-dependent dioxygenases involved in histone and DNA/RNA demethylation convert the cosubstrate 2OG and oxygen to succinate and carbon dioxide, resulting in hydroxylation of the methyl group of the substrates and subsequent
Cheng Dong +4 more
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Structure of an aromatic-ring-hydroxylating dioxygenase – naphthalene 1,2-dioxygenase [PDF]
Structure, 1998 Pseudomonas sp. NCIB 9816-4 utilizes a multicomponent enzyme system to oxidize naphthalene to (+)-cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The enzyme component catalyzing this reaction, naphthalene 1,2-dioxygenase (NDO), belongs to a family of aromatic-ring-hydroxylating dioxygenases that oxidize aromatic hydrocarbons and related compounds to cis ...
Kauppi, Björn +6 more
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Further studies on the substrate spectrum of phytanoyl-CoA hydroxylase
Journal of Lipid Research, 2003 Refsum disease is a peroxisomal disorder characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy, ataxia, and an accumulation of phytanic acid in plasma and tissues.
Veerle Foulon +5 more
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Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB
BMC Genomics, 2003 Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz +3 more
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The Contribution of Plant Dioxygenases to Hypoxia Signaling
Frontiers in Plant Science, 2020 Dioxygenases catalyze the incorporation of one or two oxygen atoms into target organic substrates. Besides their metabolic role, these enzymes are involved in plant signaling pathways as this reaction is in several instances required for hormone ...
Sergio Iacopino +5 more
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Bioengineering, 2018 Selective oxidative functionalization of molecules is a highly relevant and often demanding reaction in organic chemistry. The use of biocatalysts allows the stereo- and regioselective introduction of oxygen molecules in organic compounds at milder ...
Ana C. Fernandes +5 more
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Frontiers in Microbiology, 2018 While most studies using RNA-stable isotope probing (SIP) to date have focused on ribosomal RNA, the detection of 13C-labeled mRNA has rarely been demonstrated.
Lauren M. Bradford +6 more
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Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases
Nature Communications, 2022 Kleiner and co-workers profile RNA 5-methylcytidine (m5C) dioxygenase enzymes using an activity-based metabolic probing strategy. They reveal ALKBH1 as the major 5-formylcytidine (f5C) writer and characterize modification sites across mRNA and tRNA.
A. Emilia Arguello +5 more
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2-oxoglutarate-dependent dioxygenases: A renaissance in attention for ascorbic acid in plants.
PLoS ONE, 2020 L-Ascorbic acid (ascorbate, Vitamin C) is an essential human micronutrient that is predominantly obtained from plants. It is known to work as the major antioxidant in plants, and it underpins several environmentally induced stresses due to its use as a ...
Asaad M Mahmood, Jim M Dunwell
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Nature Communications, 2022 Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.
Romain O. Georges +8 more
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