Results 11 to 20 of about 25,696 (256)

2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins

Frontiers in Plant Science, 2014
Coumarins are natural plant products that have been the subject of extensive phytochemical and pharmacological research studies in the past few decades.
Bun-Ichi eShimizu
doaj   +2 more sources

Itaconate Inhibits TET DNA Dioxygenases to Dampen Inflammatory Responses

Nature Cell Biology, 2021
As one of the most induced genes in activated macrophages, immune-responsive gene 1 (IRG1) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid (ITA).
Lei-lei Chen, Carmen Morcelle, Zhou-Li Cheng, Xiufei Chen, Yan-ping Xu, Yajing Gao, Junbin Song, Zhijun Li, Matthew D. Smith, Miao Shi, Yezhang Zhu, Neng Zhou, Meng Cheng, Chenxi He, Kwei‐Yan Liu, Guo-xiong Lu, Lei Zhang, Cheng Zhang, Jinye Zhang, Yiping Sun, Tuan Qi, Yingying Lyu, Zhizhong Ren, Xiankui Tan, Jiayong Yin, F. Lan, Ying Liu, Hui Yang, Maoxiang Qian, C. Duan, X. Chang, Yufeng Zhou, Liguo Shen, A. Baldwin, K. Guan, Y. Xiong, D. Ye   +36 more
semanticscholar   +1 more source

Seeing the cis-Dihydroxylating Intermediate: A Mononuclear Nonheme Iron-Peroxo Complex in cis-Dihydroxylation Reactions Modeling Rieske Dioxygenases

Journal of the American Chemical Society, 2023
The nature of reactive intermediates and the mechanism of the cis-dihydroxylation of arenes and olefins by Rieske dioxygenases and synthetic nonheme iron catalysts have been the topic of intense research over the past several decades.
Wenjuan Zhu, Akhilesh Kumar, Jin Xiong, Macon J. Abernathy, Xiao‐Xi Li, M. Seo, Yong‐Min Lee, R. Sarangi, Yisong Guo, W. Nam   +9 more
semanticscholar   +1 more source

Comprehensive Analysis of Carotenoid Cleavage Dioxygenases Gene Family and Its Expression in Response to Abiotic Stress in Poplar

International Journal of Molecular Sciences, 2022
Carotenoid cleavage dioxygenases (CCDs) catalyzes the cleavage of various carotenoids into smaller apocarotenoids which are essential for plant growth and development and response to abiotic stresses.
Hui Wei, A. Movahedi, Guoyuan Liu, Yixin Li, Shiwei Liu, Chunmei Yu, Yanhong Chen, Fei Zhong, Jian Zhang   +8 more
semanticscholar   +1 more source

Substrate-Specific Coupling of O2 Activation to Hydroxylations of Aromatic Compounds by Rieske Non-heme Iron Dioxygenases

ACS Catalysis, 2022
Rieske dioxygenases catalyze the initial steps in the hydroxylation of aromatic compounds and are critical for the metabolism of xenobiotic substances. Because substrates do not bind to the mononuclear non-heme FeII center, elementary steps leading to O2
Sarah G. Pati, Charlotte E Bopp, H. Kohler, T. Hofstetter   +3 more
semanticscholar   +1 more source

Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper(II).

ACS Medicinal Chemistry Letters, 2022
Ten eleven translocation (TET) dioxygenases 1-3 are non-heme Fe(II) and α-ketoglutarate dependent enzymes that catalyze oxidation of 5-methylcytosine (5mC) in DNA to hydroxymethyl-C, formyl-C, and carboxy-C.
Nicholas A Weirath, Alexander K. Hurben, Christopher Chao, Suresh S Pujari, Tao Cheng, Shujun Liu, N. Tretyakova   +6 more
semanticscholar   +1 more source

Identification of New Dioxygenases Able to Recognize Polycyclic Aromatic Hydrocarbons with High Aromaticity

Catalysts, 2022
Polycyclic aromatic hydrocarbons (PAHs), products from the incomplete combustion of crude oil, are pollutants present in nature. Ring hydroxylating dioxygenase enzymes are able to catalyze polycyclic aromatic hydrocarbons in the biodegradation process ...
Apolonia Rodríguez, Sandra G. Zárate, Á. Bastida   +2 more
semanticscholar   +1 more source

Emerging roles for thiol dioxygenases as oxygen sensors

The FEBS Journal, 2021
Cysteine dioxygenases, 3‐mercaptopropionate dioxygenases and mercaptosuccinate dioxygenases are all thiol dioxygenases (TDOs) that catalyse oxidation of thiol molecules to sulphinates.
D. M. Gunawardana, Karen C Heathcote, E. Flashman   +2 more
semanticscholar   +1 more source

DNA Demethylation in the Processes of Repair and Epigenetic Regulation Performed by 2-Ketoglutarate-Dependent DNA Dioxygenases

International Journal of Molecular Sciences, 2021
Site-specific DNA methylation plays an important role in epigenetic regulation of gene expression. Chemical methylation of DNA, including the formation of various methylated nitrogenous bases, leads to the formation of genotoxic modifications that impair
N. Kuznetsov, L. Y. Kanazhevskaya, O. Fedorova   +2 more
semanticscholar   +1 more source

TET-family dioxygenases and the TET activator Vitamin C in immune responses and cancer.

Blood, 2020
Vitamin C serves as a cofactor for Fe (II) and 2-oxoglutarate (2OG)-dependent dioxygenases including TET family enzymes, which catalyze the oxidation of 5-methylcytosine into 5-hydroxymethylcytosine and further oxidized methylcytosines.
Xiaojing Yue, A. Rao
semanticscholar   +1 more source