Results 21 to 30 of about 14,175 (245)

Sufficiency of hypoxia-inducible 2-oxoglutarate dioxygenases to block chemical oxidative stress-induced differentiation of human embryonic stem cells

Stem Cell Research, 2019
Hypoxia benefits undifferentiated pluripotent stem cell renewal, and 2-oxoglutarate (2OG) dioxygenases have been implicated in pluripotent stem cell induction and renewal.
Eirini Koutsouraki, Steve Pells, Paul A. De Sousa   +2 more
doaj   +1 more source

Diversity of aromatic hydroxylating dioxygenase genes in mangrove microbiome and their biogeographic patterns across global sites

MicrobiologyOpen, 2017
Aromatic hydrocarbons (AH), such as polycyclic aromatic hydrocarbons, are compounds largely found in nature. Aromatic‐ring‐hydroxylating dioxygenases (ARHD) are proteins involved in AH degradation pathways.
Sanderson T. P. deSousa, Lucélia Cabral, Gileno Vieira Lacerda Júnior, Valéria M. Oliveira   +3 more
doaj   +1 more source

Functional diversity of bacterial genes associated with aromatic hydrocarbon degradation in anthropogenic dark earth of Amazonia

Pesquisa Agropecuária Brasileira, 2012
The objective of this work was to evaluate the catabolic gene diversity for the bacterial degradation of aromatic hydrocarbons in anthropogenic dark earth of Amazonia (ADE) and their biochar (BC).
Mariana Gomes Germano, Fabiana de Souza Cannavan, Lucas William Mendes, Amanda Barbosa Lima, Wenceslau Geraldes Teixeira, Vivian Helena Pellizari, Siu Mui Tsai   +6 more
doaj   +1 more source

Oxygen concentration controls epigenetic effects in models of familial paraganglioma. [PDF]

PLoS ONE, 2015
Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the genes encoding the subunits of succinate dehydrogenase (SDH), a tricarboxylic acid (TCA) cycle enzyme.
Yeng F Her, Molly Nelson-Holte, Louis James Maher   +2 more
doaj   +1 more source

2-Oxoglutarate: linking TCA cycle function with amino acid, glucosinolate, flavonoid, alkaloid and gibberellin biosynthesis

Frontiers in Plant Science, 2014
The tricarboxylic acid (TCA) cycle intermediate 2-oxoglutarate (2-OG) is used as an obligatory substrate in a range of oxidative reactions catalyzed by 2-OG-dependent dioxygenases.
Wagner L. Araújo, Wagner L. Araújo, Auxiliadora O Martins, Alisdair eFernie, Takayuki eTohge   +4 more
doaj   +1 more source

Discovery and Characterization of a Second Mammalian Thiol Dioxygenase, Cysteamine Dioxygenase [PDF]

Journal of Biological Chemistry, 2007
There are only two known thiol dioxygenase activities in mammals, and they are ascribed to the enzymes cysteine dioxygenase (CDO) and cysteamine (2-aminoethanethiol) dioxygenase (ADO). Although many studies have been dedicated to CDO, resulting in the identification of its gene and even characterization of the tertiary structure of the protein ...
John E, Dominy, Chad R, Simmons, Lawrence L, Hirschberger, Jesse, Hwang, Relicardo M, Coloso, Martha H, Stipanuk   +5 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Biochemistry and occurrence of O-demethylation in plant metabolism

Frontiers in Physiology, 2010
Demethylases play a pivitol role in numerous biological processes from covalent histone modification and DNA repair to specialized metabolism in plants and microorganisms.
Jillian Hagel, Peter Facchini
doaj   +1 more source

Subsurface hydrocarbon degradation strategies in low- and high-sulfate coal seam communities identified with activity-based metagenomics

npj Biofilms and Microbiomes, 2022
Environmentally relevant metagenomes and BONCAT-FACS derived translationally active metagenomes from Powder River Basin coal seams were investigated to elucidate potential genes and functional groups involved in hydrocarbon degradation to methane in coal
Hannah D. Schweitzer, Heidi J. Smith, Elliott P. Barnhart, Luke J. McKay, Robin Gerlach, Alfred B. Cunningham, Rex R. Malmstrom, Danielle Goudeau, Matthew W. Fields   +8 more
doaj   +1 more source

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source