Discovery and Characterization of a Second Mammalian Thiol Dioxygenase, Cysteamine Dioxygenase [PDF]
Journal of Biological Chemistry, 2007 There are only two known thiol dioxygenase activities in mammals, and they are ascribed to the enzymes cysteine dioxygenase (CDO) and cysteamine (2-aminoethanethiol) dioxygenase (ADO). Although many studies have been dedicated to CDO, resulting in the identification of its gene and even characterization of the tertiary structure of the protein ...
Chad R. Simmons +5 more
openaire +3 more sources
TET-family dioxygenases and the TET activator Vitamin C in immune responses and cancer.
Blood, 2020 Vitamin C serves as a cofactor for Fe (II) and 2-oxoglutarate (2OG)-dependent dioxygenases including TET family enzymes, which catalyze the oxidation of 5-methylcytosine into 5-hydroxymethylcytosine and further oxidized methylcytosines.
Xiaojing Yue, A. Rao
semanticscholar +1 more source
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones. [PDF]
PLoS ONE, 2011 2-Oxoglutarate (2OG) dependent dioxygenases are ubiquitous iron containing enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide.
Hanne Korvald +6 more
doaj +1 more source
Application of nitroarene dioxygenases in the design of novel strains that degrade chloronitrobenzenes. [PDF]
, 2009 Widespread application of chloronitrobenzenes as feedstocks for the production of industrial chemicals and pharmaceuticals has resulted in extensive environmental contamination with these toxic compounds, where they pose significant risks to the health ...
Ju, Kou-San, Parales, Rebecca E
core +1 more source
Structure and function prediction of human homologue hABH5 of _E. coli_ ALKB5 using in silico approach [PDF]
, 2011 Newly discovered human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Little is known about the structure and function of hABH5, one of the members of this superfamily.
Ambarish Sharan Vidyarthi +2 more
core +5 more sources
The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus [PDF]
, 2019 Aims: Quinone compounds are electron carriers and have antimicrobial and toxic properties due to their mode of actions as electrophiles and oxidants.
Fritsch, Verena Nadin +9 more
core +1 more source
Synthetic, Spectroscopic and DFT Studies of Iron Complexes with Iminobenzo(semi)quinone Ligands: Implications for o-Aminophenol Dioxygenases [PDF]
, 2013 The oxidative CC bond cleavage of o-aminophenols by nonheme Fe dioxygenases is a critical step in both human metabolism (the kynurenine pathway) and the microbial degradation of nitroaromatic pollutants. The catalytic cycle of o-aminophenol dioxygenases (
Bittner, Michael M. +4 more
core +2 more sources
Cofactor Generation Cascade for α-Ketoglutarate and Fe(II)-Dependent Dioxygenases
ACS Sustainable Chemistry and Engineering, 2020 Fe(II)- and α-ketoglutarate dependent dioxygenases have emerged as important catalysts for the preparation of non-natural amino acids. The stoichiometric supply of the cosubstrate α-ketoglutarate (αKG) is an important cost factor.
F. Busch +4 more
semanticscholar +1 more source
Isolation and characterization of Alicycliphilus denitrificans strain BC, which grows on benzene with chlorate as the electron acceptor [PDF]
, 2008 A bacterium, strain BC, was isolated from a benzene-degrading chlorate-reducing enrichment culture. Strain BC degrades benzene in conjunction with chlorate reduction.
Broeke, H., ten +8 more
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Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB
BMC Genomics, 2003 Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz +3 more
doaj +1 more source