Results 41 to 50 of about 34,889 (336)

Subsurface hydrocarbon degradation strategies in low- and high-sulfate coal seam communities identified with activity-based metagenomics

npj Biofilms and Microbiomes, 2022
Environmentally relevant metagenomes and BONCAT-FACS derived translationally active metagenomes from Powder River Basin coal seams were investigated to elucidate potential genes and functional groups involved in hydrocarbon degradation to methane in coal
Hannah D. Schweitzer, Heidi J. Smith, Elliott P. Barnhart, Luke J. McKay, Robin Gerlach, Alfred B. Cunningham, Rex R. Malmstrom, Danielle Goudeau, Matthew W. Fields   +8 more
doaj   +1 more source

Discovery and Characterization of a Second Mammalian Thiol Dioxygenase, Cysteamine Dioxygenase [PDF]

Journal of Biological Chemistry, 2007
There are only two known thiol dioxygenase activities in mammals, and they are ascribed to the enzymes cysteine dioxygenase (CDO) and cysteamine (2-aminoethanethiol) dioxygenase (ADO). Although many studies have been dedicated to CDO, resulting in the identification of its gene and even characterization of the tertiary structure of the protein ...
John E, Dominy, Chad R, Simmons, Lawrence L, Hirschberger, Jesse, Hwang, Relicardo M, Coloso, Martha H, Stipanuk   +5 more
openaire   +2 more sources

Degradation of Chloroaromatics: Purification and Characterization of a Novel Type of Chlorocatechol 2,3-Dioxygenase of Pseudomonas putida GJ31 [PDF]

, 1998
A purification procedure for a new kind of extradiol dioxygenase, termed chlorocatechol 2,3-dioxygenase, that converts 3-chlorocatechol productively was developed.
Janssen, Dick B.,, Kasberg, Thomas,, Kaschabek, Stefan R.,, Mars, Astrid E.,, Müller, Dagmar,, Reineke, Walter,   +5 more
core   +2 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Enrichment and Identification of Askarel oil (PCB blend) degrading bacteria enriched from landfill sites in Edo State, Nigeria. [PDF]

, 2011
Microbial degradation following aerobic biodegradation is one of the means used by microorganisms for the removal of persistent organic pollutants from the soil. Bacterial species namely: Pseudomonas, Micrococcus Arthrobacter and Acinetobacter capable of
Nwinyi, Obinna
core   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Genome Sequence and Metabolic Analysis of a Fluoranthene-Degrading Strain Pseudomonas aeruginosa DN1

Frontiers in Microbiology, 2018
Pseudomonas aeruginosa DN1, isolated from petroleum-contaminated soil, showed excellent degradation ability toward diverse polycyclic aromatic hydrocarbons (PAHs). Many studies have been done to improve its degradation ability.
Chunqiu He, Yanpeng Li, Chao Huang, Fulin Chen, Yanling Ma   +4 more
doaj   +1 more source

Characterization of novel PAH dioxygenases from the bacterial metagenomic DNA of a contaminated soil. [PDF]

, 2014
International audienceRing hydroxylating dioxygenases (RHDs) play a crucial role in the biodegradation of a range of aromatic hydrocarbons found on polluted sites, including polycyclic aromatic hydrocarbons (PAHs).
Chemerys, Angelina, Cruaud, Corinne, Jouanneau, Yves, Martin, Florence, Pelletier, Eric, Violet, Fabien   +5 more
core   +3 more sources

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Oncometabolites: tailoring our genes [PDF]

, 2015
Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core   +1 more source