Results 121 to 130 of about 83,323 (258)

Enantiopurity‐Dependent Peptide Coacervates and Asymmetric Organocatalysis

Small, EarlyView.
Enantiopure peptide LLLPFF‐OCH3 forms liquid–liquid phase‐separated (LLPS) droplets that act as chiral microreactors for enantioselective aldol catalysis. Racemic mixtures fail to undergo LLPS, showing spontaneous enantiomeric self‐disproportionation (SDE).
Alice Vetrano, Nico di Fonte, Olivier Monasson, Federico Perrella, Martina Porco, Ferdinando Mercuri, Gianluca Dell'Orletta, Francesco Petragnano, Alessio Carioscia, Davide Deodato, Damiano Calcagno, Giovanna Salvitti, Samantha Reale, Fabio Pesciaioli, Carino Ferrante, Davide Tedeschi, Giuseppe Grasso, Paola Benassi, Elisa Peroni, Armando Carlone, Isabella Daidone, Claudio Iacobucci   +21 more
wiley   +1 more source

Amino acids – Guidelines on Parenteral Nutrition, Chapter 4

GMS German Medical Science, 2009
Protein catabolism should be reduced and protein synthesis promoted with parenteral nutrion (PN). Amino acid (AA) solutions should always be infused with PN. Standard AA solutions are generally used, whereas specially adapted AA solutions may be required
Working group for developing the guidelines for parenteral nutrition of The German Association for Nutritional Medicine, Goeters, C., Schulz, R., Blumenstein, I., Boehles, H. J., Stein, J.   +5 more
doaj  

Molecular characterization of transformer, transformer‐2, and doublesex genes in the carambola fruit fly, Bactrocera carambolae, revealing potential for genetic pest management

Insect Science, EarlyView.
Abstract Globalization and climate change may be driving the spread of the quarantine fruit fly, Bactrocera carambolae, highlighting the need for ecofriendly control methods like the Sterile Insect Technique (SIT), which relies on releasing sterile males to reduce wild populations.
Kamoltip Laohakieat, Thanalai Poonsiri, Nidchaya Aketarawong   +2 more
wiley   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201

Allergy, EarlyView.
Graphical The crystal structure of a major peanut allergen Ara h 2.0201 in a complex with a human‐derived IgE Fab fragment has been determined. The immunocomplex shows the trivalent binding of Fabs, creating a cross‐linked structure effective in the formation of large complexes on the surface of effector cells. Hydroxylation of proline has implications
Tarja Parkkinen, Heidi Heiniluoto, Janne Jänis, Kristiina Takkinen, Juha Rouvinen   +4 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Crystal structures of the isomeric dipeptides l-glycyl-l-methionine and l-methionyl-l-glycine

Acta Crystallographica Section E: Crystallographic Communications
The oxidation of methionyl peptides can contribute to increased biological (oxidative) stress and development of various inflammatory diseases. The conformation of peptides has an important role in the mechanism of oxidation and the intermediates formed ...
Sainath Babu, Frank R. Fronczek, Rao M. Uppu, Michelle O. Claville   +3 more
doaj   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat

The FEBS Journal, EarlyView.
Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Pd(II)–Prolinate Prolinium and Pd(II)–LysGly Complexes Catalyzed the Enantioselective Aldol, Morita–Baylis–Hillman and Heck Reactions

Molecules
The induction of chirality to obtain enantiopure products of high synthetic value is of great importance across various scientific fields, particularly in the medical area, as it has been demonstrated that the different enantiomers of drugs interact ...
Juan Carlos Jiménez-Cruz, Ramón Guzmán-Mejía, Verónica Cortés-Muñoz, Manuel Solís-Hernández, Hugo A. García-Gutiérrez, Julio C. Ontiveros-Rodríguez, Stephanie García-Zavala, Judit A. Aviña-Verduzco   +7 more
doaj   +1 more source