Results 151 to 160 of about 3,651 (206)
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Antidiabetic Effect of a New Original NT-3 Dipeptide Mimetic
Doklady Biochemistry and Biophysics, 2023It was previously established that the original dipeptide mimetic of the 4th loop of NT-3, hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301), has a pronounced neuroprotective effect in vitro at concentrations of 10–5–10–12 М.
S S, Yagubova +4 more
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Antiangiogenic Effects of Nerve Growth Factor Loop 4 Monomeric Dipeptide Mimetic
Bulletin of Experimental Biology and Medicine, 2017The effects of GK-1, a monomeric dipeptide mimetic of nerve growth factor (NGF) loop 4, on angiogenesis were studied in vitro and in vivo. Experiments on human umbilical vein endothelial cells HUVEC showed that the test compound did not affect tubulogenesis (initial stage of angiogenesis) and prevented realization of the angiogenic effect of NGF and ...
Sergei V Nikolaev, Irina A Miroshkina
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An Achiral Dipeptide Mimetic That Promotes .beta.-Hairpin Formation
Journal of the American Chemical Society, 1995Robb R. Gardner +2 more
exaly +2 more sources
Synthesis of constrained bicyclic dipeptide mimetics
Tetrahedron Letters, 1997Abstract An efficient synthesis of constrained bicyclic peptidomimetics of (R)-Phe-Pro dipeptide is described. Such mimetics may provide an opportunity to develop inhibitors of thrombin possessing the desired pharmacological features.
M.Arshad Siddiqui +7 more
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Conformational analysis of dipeptide mimetics
Biopolymers, 1997A compendium of compounds designed as dipeptide mimetics was collected from the literature. Conformational space available to these molecules was evaluated to obtain distance and torsion angle parameters to aid in selection of mimetics for specific target peptides or to explore diversity strategies.
Paul Gillespie +2 more
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The design of polar β-turn dipeptide mimetics
Bioorganic & Medicinal Chemistry Letters, 1995Abstract The design and synthesis of conformationally constrained, non-peptide templates (3-substituted pyrrolidines) which allow the incorporation of two adjacent amino acid side-chains in an orientation similar to that found in the i+1 and i+1 positions of a β-turn are reported.
David C. Horwell +3 more
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Bradykinin antagonists modified with dipeptide mimetic β-turn inducers
Bioorganic & Medicinal Chemistry Letters, 2006Bradykinin (BK) is involved in a wide variety of pathophysiological processes. Potent BK peptide antagonists can be developed introducing constrained unnatural amino acids, necessary to force the secondary structure of the molecule. In this paper, we report a structure-activity relationship study of two peptide analogues of the potent B2 antagonist HOE
M. C. ALCARO +9 more
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Antidiabetic activity of a novel dipeptide mimetic of nerve growth factor
Doklady Biological Sciences, 201376 An antidiabetic effect of the new nerve growth fac tor (NGF) dipeptide mimetic GK 2 has been shown in rats with streptozotocininduced diabetes. The pep tide has a significant antihyperglycemic effect in the course of treatment: intraperitoneal injection at a dose of 0.5 mg/kg for two weeks before and four weeks after the toxin injection. GK 2 also
P Yu, Povarnina +4 more
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Synthesis of an Optically Active, Bicyclic 2-Pyridone Dipeptide Mimetic
The Journal of Organic Chemistry, 2002The eleven-step preparation of the bicyclic 2-pyridone dipeptide mimetic 1 [(3S)-6-(benzyloxycarbonylamino)-5-oxo-1,2,3,5-tetrahydroindolizine-3-carboxylic acid] in optically active form (60% ee) is described. Key steps in the synthesis of 1 include the osmium-catalyzed asymmetric dihydroxylation of olefin 13 [(6-but-3-enyl-2-methoxypyridin-3-yl ...
Peter S, Dragovich +2 more
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Dipeptide Mimetics of Different NGF and BDNF Loops Activate PLC-γ1
Doklady Biochemistry and Biophysics, 2020Previously, we designed and synthesized dipeptide mimetics of individual loops of the nerve growth factor (NGF) and the brain-derived neurotrophic factor (BDNF). It was shown that these mimetics activate the corresponding tyrosine kinase (Trk) receptors and have different patterns of activation of the PI3K/AKT and MAPK/ERK postreceptor signaling ...
T A, Gudasheva +5 more
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