Results 161 to 170 of about 3,651 (206)

Design and synthesis of dipeptide mimetics of the brain-derived neurotrophic factor

Russian Journal of Bioorganic Chemistry, 2012
Low-molecular mimetics of brain-derived neurotrophic factor (BDNF) loops 1 and 4 representing to monomeric and dimeric amides of N-acyldipeptides were constructed and synthesized. The sequence of these dipeptides coinside with the central regions of beta-turns of corresponding loops of neurotrophine sequence, and acyl groups are bioisosters of ...
T A, Gudasheva, A V, Tarasiuk, S V, Pomogaĭbo, I O, Logvinov, P Iu, Povarnina, T A, Antipova, S B, Seredenin   +6 more
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Synthesis of bicyclic dipeptide mimetics for the cholecystokinin and opioid receptors

Tetrahedron Letters, 2004
Abstract The cholecystokinin C-terminal octapeptide analogue H-Asp-Tyr-D-Phe-Gly-Trp-(N-Me)-Nle-Asp-Phe-NH2 (SNF 9007) is a potent and selective ligand for both the CCK-B and δ-opioid receptors. To constrain the peptide into the biologically active conformation(s), bicyclic dipeptide mimetics for Nle-Gly and homoPhe-Gly were designed and synthesized ...
John M. Ndungu, Xuyuan Gu, Dustin E. Gross, James P. Cain, Michael D. Carducci, Victor J. Hruby   +5 more
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Immunologically active mimetics of muramyl dipeptide

2005
N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide, MDP) is the minimal immunologically active component of the bacterial cell wall peptidoglycan [1]. In last 20 years many research groups have been concerned with the synthesis and immunological studies of derivatives of this highly active glycopeptide in order to obtain molecules with improved
Danijel Kikelj, Alenka Rutar, Irena Merslavič, Lučka Povšič, Anton Štalc   +4 more
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Synthesis of dipeptide secondary structure mimetics

2005
Masakatsu Eguchi, Hwa-Ok Kim, Benjamin S. Gardner, P. Douglas Boatman, Min S. Lee, Hiroshi Nakanishi and Michael Kahn Molecumetics Ltd., 2023 120th Ave. N.E., Suite 400, Bellevue, WA 98005, USA and Department of Pathobiology, University of Washington, Seattle, WA, 98195, USA Secondary structures in proteins and peptides play an important role in ...
Masakatsu Eguchi, Hwa-Ok Kim, Benjamin S. Gardner, P. Douglas Boatman, Min S. Lee, Hiroshi Nakanishi, Michael Kahn   +6 more
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A simple and efficient synthesis of an Asp-Gly dipeptide mimetic

Tetrahedron Letters, 2004
Abstract Alkylation of N α -Boc protected aspartic acid with allyl bromide in the presence of lithium bis(trimethylsilyl)amide (LHMDS) and hexamethylphosphoramide (HMPA) afforded chiral β-allyl substituted aspartic acid in good yields. After deprotection of the N α -Boc group and reprotection as a trifluoroacetamide, the terminal alkene was oxidized ...
John M. Ndungu, Xuyuan Gu, Dustin E. Gross, Jinfa Ying, Victor J. Hruby   +4 more
openaire   +1 more source

ChemInform Abstract: Synthesis of Constrained Bicyclic Dipeptide Mimetics.

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. A. SIDDIQUI, P. PREVILLE, M. TARAZI, S. E. WARDER, P. EBY, E. GORSETH, K. PUUMALA, J. DIMAIO   +7 more
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Stereoselective Synthesis of Aza‐ and Diazabicyclo[X.Y.0]alkane Dipeptide Mimetics

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Wolfgang Maison, Alexander H. Prenzel
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Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics

Journal of Medicinal Chemistry, 1991
A series of renin inhibitors containing lactam-bridged P1-P1' dipeptide mimetics based on the ACHPA (4(S)-amino-5-cyclohexyl-3(S)-hydroxypentanoic acid) design was studied. The inhibitors were obtained by aldol addition of various lactams with N alpha-Boc-L-cyclohexylalaninal, followed by Boc group removal and acylation with Boc-Phe-His.
P D, Williams, D S, Perlow, L S, Payne, M K, Holloway, P K, Siegl, T W, Schorn, R J, Lynch, J J, Doyle, J F, Strouse, G P, Vlasuk   +9 more
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Synthesis of new β-turn dipeptide mimetic based on tetrahydroisoquinoline moiety

Tetrahedron Letters, 2002
Abstract A new β-turn dipeptide mimetic was performed by a Pictet–Spengler condensation, starting from L-DOPA and the corresponding aldehyde derived from Fmoc-L-Ala-OH.
GRIECO, PAOLO, CAMPIGLIA P., GOMEZ MONTERREY, ISABEL MARIA, NOVELLINO E.   +3 more
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Stereoselective Synthesis of (Z)-Alkene-Containing Proline Dipeptide Mimetics

The Journal of Organic Chemistry, 2006
In peptides and proteins, the peptide bond between an amino acid and proline exists as an equilibrium mixture of the cis-imide and trans-imide due to the low energy barrier in their interconversion. This feature greatly influences the structure and function of the proline-containing peptides and proteins.
Yoshikazu, Sasaki, Ayumu, Niida, Takashi, Tsuji, Akira, Shigenaga, Nobutaka, Fujii, Akira, Otaka   +5 more
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