Results 11 to 20 of about 3,651 (206)
Peptide-Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries. [PDF]
Adv Sci (Weinh)Peptide‐incorporated biomaterials provide precise, tunable biological cues that mimic functional protein domains to regulate behaviors of neurons, Schwann cells, immune cells, and endothelial cells, thereby enhancing axon elongation, Schwann cell support, inflammatory microenvironment modulation, and vascularization, offering a promising alternative to
Zhao Z +5 more
europepmc +2 more sources
Isolation, Purification, Identification, and In Vitro ACE Inhibitory Activity of Tyrosine‐Arginine Dipeptide From Red Millet Huangjiu [PDF]
Food Sci NutrThis study identified a novel ACE inhibitory dipeptide, Tyr‐Arg (YR), from red millet Huangjiu using multi‐step purification and ESI‐MS/MS. Tyr‐Arg exhibited effective inhibitory activity with an IC50 of 158.93 ± 0.39 μM. Molecular docking and 100‐ns molecular dynamics (MD) simulations revealed a non‐competitive inhibition mechanism, where Tyr‐Arg ...
Li J, Zhong J, Zhang X.
europepmc +2 more sources
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites [PDF]
, 2014 N-Myristoyltransferase (NMT) has been shown to be essential in Leishmania and subsequently validated as a drug target in Plasmodium. Herein, we discuss the use of antifungal NMT inhibitors as a basis for inhibitor development resulting in the first sub ...
Brannigan, JA +5 more
core +4 more sources
Фармакокинетика и Фармакодинамика, 2023 To assess the pharmacological safety of the dipeptide mimetic of the 2nd loop of BDNF (compound GTS-201) when co-administered with ethanol, its effect on the alteration in motor activity induced by ethanol during acute and subchronic administration in ...
A. V. Nadorova +4 more
doaj +1 more source
Фармакокинетика и Фармакодинамика, 2022 Earlier, in experiments in vitro and in vivo, it was shown that the TrkA receptor agonist compound GK-2, which was a low molecular weight NGF mimetic, had pronounced angiogenic and antiischemic activity. However, it remained unclear whether this activity
E. S. Pekeldina +5 more
doaj +1 more source
Sum frequency generation spectroscopy of the attachment disc of a spider [PDF]
, 2021 The pyriform silk of the attachment disc of a spider was studied using infrared-visible vibrational sum frequency generation (SFG) spectroscopy. The spider can attach dragline and radial lines to many kinds of substrates in nature (concrete, alloy, metal,
Hien, Khuat Thi Thu +5 more
core +2 more sources
Фармакокинетика и Фармакодинамика, 2023 The pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GC-2 in the rat blood plasma after different routes of administration was studied. The drug was administered at dose of 150 mg/kg by single and repeatedly.
O. Yu. Kravtsova +6 more
doaj +1 more source
, 2011 Biomaterials are often soft materials. There is now growing interest in designing, synthesizing and characterising soft materials that mimic the properties of biological materials such as tissue, proteins, DNA or cells. Research on biomimetic soft matter
Hamley, Ian
core +1 more source
Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]
, 2005 MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga +6 more
core +1 more source
Фармакокинетика и Фармакодинамика, 2021 The purpose of the study. In experiments on a hind limb ischemia model in rats, the effect of the TrkA-receptor agonist of the NGF 4th loop dimeric dipeptide mimetic compound GK-2 has been studied on microcirculation in ischemic skeletal muscle.Methods ...
I. B. Tsorin +4 more
doaj +1 more source