Results 31 to 40 of about 3,651 (206)

Comparison of neuroprotective properties of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor on the model oxidative stress in vitro

Фармакокинетика и Фармакодинамика, 2019
Resume. The purpose of this study was to compare neuroprotective properties of the dimeric dipeptide mimetics of the 1st, 2nd and 4th Loops of BDNF - GSB-214 (heptamethylenediamide bis-monosuccinyl-methionyl-serine), GTS-201 (hexamethylenediamide bis ...
I. O. Logvinov, A. V. Tarasiuk, N. M. Sazonova, P. I. Antipov, T. A. Antipova, T. A. Gudasheva   +5 more
doaj   +1 more source

Introduction to protein folding for physicists [PDF]

, 2007
The prediction of the three-dimensional native structure of proteins from the knowledge of their amino acid sequence, known as the protein folding problem, is one of the most important yet unsolved issues of modern science.
Abagyan R. A., Arnold V. I., Calera C. Gómez-Moreno, Chothia C., Creighton T. E., Dawkins R., Dawkins R., Drenth J., Dubrovin B. A., Fersht A., Gibson G., Goldstein H., Greiner W., Halgren T. A., Haltia T., Head-Gordon T., Lesk A. M., Levinthal C., Pablo Echenique, Plotkin S. S., Smith C., van Kampen N. G.   +21 more
core   +3 more sources

Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials [PDF]

, 2012
A series of cinnamic acid/4-aminoquinoline conjugates conceived to link, through a proper retro-enantio dipeptide, a heterocyclic core known to prevent hemozoin formation, to a trans-cinnamic acid motif capable of inhibiting enzyme catalytic Cys residues,
Bianca C Perez, Cada Teixeira, Jiri Gut, Jose R B Gomes, Marta Figueiras, Paula Gomes, Philip J Rosenthal   +6 more
core   +1 more source

High resolution structures define divergent and convergent mechanisms of archaeal proteasome activation

Communications Biology, 2023
Considering the link between neurodegenerative diseases and impaired proteasome function, and the neuro-protective impact of enhanced proteasome activity in animal models, it’s crucial to understand proteasome activation mechanisms.
Janelle J. Y. Chuah, Matthew S. Rexroad, David M. Smith   +2 more
doaj   +1 more source

GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN [PDF]

, 2008
The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e.
Stridh, Malin
core   +1 more source

Combination of Innate Immune Modulators as Vaccine Adjuvants in Mice

Vaccines, 2020
The development of new, effective, and safe vaccines necessarily requires the identification of new adjuvant(s) to enhance the potency and longevity of antigen-specific immune responses.
Azita Haddadi, Alyssa Chaffey, Siew Hon Ng, Damayanthi Yalamati, Heather L. Wilson   +4 more
doaj   +1 more source

New CHARMM force field parameters for dehydrated amino acid residues, the key to lantibiotic molecular dynamics simulations [PDF]

, 2014
Lantibiotics are an important class of naturally occurring antimicrobial peptides containing unusual dehydrated amino acid residues. In order to enable molecular dynamics simulations of lantibiotics, we have developed empirical force field parameters for
Aidas, Alagona, Aleman, Asaduzzaman, Bierbaum, Bonev, Bonev, Breukink, Breukink, Brooks, Brooks, Case, Chan, Chan, Chan, Chugunov, Darden, Dischinger, Feller, Foloppe, Giffard, Gut, Guvench, Hasper, Hsu, Hsu, Hutchinson, Hyde, Jensen, Jia, Jo, Jo, Jorgensen, Karpen, Keal, Klauda, Kuipers, Lian, MacKerell Jr, Mackerell Jr, Mackerell Jr, Mathur, Parisot, Phillips, Rauk, Ryckaert, Shao, Siodłak, Slijper, Turpin, Ulrich, Van de Kamp, van de Ven, van den Hooven, Van Den Hooven, Van den Hooven, Van der Meer, Vanommeslaeghe, Vanommeslaeghe, Wiedemann, Willey   +60 more
core   +3 more sources

Cyclic RGD peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands [PDF]

, 2012
The synthesis of eight bifunctional diketopiperazine (DKP) scaffolds is described; these were formally derived from 2,3-diaminopropionic acid and aspartic acid (DKP-1-DKP-7) or glutamic acid (DKP-8) and feature an amine and a carboxylic acid functional ...
Arosio D., Belvisi L., Colombo R., Gennari C., Guzzetti I., Marchini M., Mingozzi M., Piarulli U., Potenza D., Vasile F.   +9 more
core   +1 more source

Dimeric dipeptide mimetics of BDNF loop 4 are potential antidepressants with novel mechanisms of action

Фармакокинетика и Фармакодинамика
This review covers original research focused on the design, synthesis, and pharmacological evaluation of an innovative dimeric dipeptide mimetic of brain-derived neurotrophic factor (BDNF) loop 4 bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide
T. A. Gudasheva, P. Yu. Povarnina, A. V. Tarasyuk, V. P. Zherdev, A. D. Durnev   +4 more
doaj   +1 more source

Bio-Memristor Based on Peptide and Peptide Composite with Gold Nanoparticles [PDF]

EPJ Web of Conferences, 2019
The structure, morphology and electrical properties of thin dipeptide hexamethylenediamide bis (N-monosuccinylglutamlysin) (DPT) layers and a DPT composite with gold nanoparticles deposited on gold and HOPG substrates were studied by probe microscopy and
Loskutov Alexander
doaj   +1 more source