Results 51 to 60 of about 3,651 (206)

Multicomponent Dipeptide Supramolecular Hydrogels as Fibronectin-Mimetic Biomaterials

Peptides 2015, Proceedings of the 24th American Peptide Symposium, 2015
Self-assembled supramolecular peptide hydrogels are important biomaterials that have been designed as matrices for tissue engineering and regenerative medicine [1-4]. Hydrogels derived from low molecular weight dipeptides or functionalized amino acids are a subset of self-assembled peptide hydrogels that have garnered significant recent interest [5-7].
Wathsala Liyanage, Bradley L. Nilsson
openaire   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

The study of the acute and chronic toxicity dipeptide mimetic of brain-derived neurotrophic factor GSB-106 finished dosage form

Фармакокинетика и Фармакодинамика, 2019
Resume. The study of acute and chronic toxicity of the finished dosage form (SFF) GSB-106, the active substance of which is the substituted dimeric peptide, hexamethylenediamine bis (N-monosuccinyl-L-seryl-L-lysine), which has antidepressant and ...
S. V. Alekseeva, A. V. Sorokina, A. V. Volkova, V. V. Zabrodina, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zaharov, P. Yu. Povarnina, A. D. Durnev   +9 more
doaj   +1 more source

Self-assembly of peptide bioconjugates: selected recent research highlights [PDF]

, 2017
This Topical Review briefly discusses selected highlights of recent research on self-assembling peptide amphiphiles (PAs) and polymer–peptide conjugates. Subjects covered include new polymer chemistries used to prepare polymer–peptide conjugates, PA self-
Castelletto, Valeria, Hamley, Ian W.
core   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Dimeric dipeptide mimetic the 1st loop of nerve growth factor of GK-6, which activates PI3K/AKT and MEK/MAPK/ERK, causes a neuronal type differentiation of PC12 cells

Фармакокинетика и Фармакодинамика, 2017
Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric
T. A. Antipova, S. V. Nikolaev, A. V. Revishchin, E. A. Savchenko, G. V. Pavlova, T. A. Gudasheva   +5 more
doaj  

Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water [PDF]

, 2019
Self-assembling peptides have the ability to spontaneously aggregate into large ordered structures. The reversibility of the peptide hydrogen bonded supramolecular assembly make them tunable to a host of different applications, although it leaves them ...
Brendel, Johannes C., Cox, Henry, Ellacott, Sean H., Hartlieb, Matthias, Mansfield, Edward D. H., Peltier, Raoul, Perrier, Sébastien, Rho, Julia Y., Waigh, Thomas A.   +8 more
core   +1 more source

Shear‐Induced Anisotropic Supramolecular Gel Noodles for Improved Cell Guidance in Polarized Tissue Engineering

Small, Volume 22, Issue 26, 8 May 2026.
A simple two‐stage extrusion aligns supramolecular fibrils into 1D gel noodles. The residual pressure in the viscous pre‐gel drives the formation of a thin filament that is locked by Ca2+ cross‐linker into a highly anisotropic segment. The aligned noodles show enhanced tensile strength and guide myoblast elongation along the fiber, mimicking aligned ...
Dipankar Ghosh, Matthew Walker, Lauren Matthews, Charlie Patterson, Oana Dobre, Massimo Vassalli, Dave J. Adams   +6 more
wiley   +1 more source

Study of acute toxicity of dimeric dipeptide mimetic of neurotrophin-3 in mice

Фармакокинетика и Фармакодинамика
Introduction. Low-molecular-weight mimetics of neurotrophin-3 (NT-3) are considered promising compounds for the development of novel drugs. One of the first stages in the preclinical studies of candidate drugs is the assessment of acute toxicity. The aim
I. V. Alekseev, I. A. Miroshkina, A. V. Sorokina, S. V. Alekseeva, A. V. Volkova, A. D. Zakharov, K. S. Kachalov, I. B. Tsorin, L. G. Kolik, A. D. Durnev   +9 more
doaj   +1 more source

Design of decorated self-assembling peptide hydrogels as architecture for mesenchymal stem cells [PDF]

, 2016
Hydrogels from self-assembling ionic complementary peptides have been receiving a lot of interest from the scientific community as mimetic of the extracellular matrix that can offer three-dimensional supports for cell growth or can become vehicles for ...
Cavo, Marta, Dettin, Monica, Gloria, Antonio, Marletta, Giovanni, Messina, Grazia Maria Lucia, Russo, Teresa, Scaglione, Silvia, Zamuner, Annj   +7 more
core   +2 more sources