Results 71 to 80 of about 3,651 (206)

Synthesis and the antidepressant-like activity investigation of bis-(N-monosuccinyl-D-seryl-D-lysine) hexamethylenediamide, the DD-enantiomer of the BDNF dipeptide mimetic, compound GSB-106

Фармакокинетика и Фармакодинамика
Previously, based on the β-turn of the fourth loop of the brain-derived neurotrophic factor, we obtained GSB-106 (bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide), that has pronounced neuroprotective and antidepressant activities in doses of 0.
N. M. Sazonova, A. V. Tarasyuk, M. Yu. Filippova, M. V. Melnikova, D. M. Nikiforov, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev   +7 more
doaj   +1 more source

Research of neuroprotective properties of TrkA-receptor agonist GK-2 on model of oxidative stress in human vascular endothelial cells (HUVEC)

Фармакокинетика и Фармакодинамика, 2019
Oxidative stress resulted to decrease in cells viability compared to the control (78 ± 5 % and 100 ± 6 %, respectively, р < 0,05). GK-2 and NGF prevented H2O2-induced HUVEC cells damages (95 ± 3 % for HA-2 and 97 ± 4 % for NGF vs.
T. A. Antipova, S. V. Nikolaev, S. A. Kryzhanovsky, E. S. Pekeldina   +3 more
doaj   +1 more source

All‐atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone‐binding element [PDF]

, 2013
Insulin regulates blood glucose levels in higher organisms by binding to and activating insulin receptor (IR), a constitutively homodimeric glycoprotein of the receptor tyrosine kinase (RTK) superfamily. Therapeutic efforts in treating diabetes have been
Abrams, Cameron F., Vashisth, Harish
core   +1 more source

Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF

Фармакокинетика и Фармакодинамика, 2016
On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (
T. A. Antipova, I. O. Logvinov, S. V. Nikolaev, S. V. Kruglov, A. V. Tarasiuk, P. I. Antipov, T. A. Gudasheva, S. B. Seredenin   +7 more
doaj  

Peptide and Protein Hydrogels [PDF]

, 2012
Proteins are a fascinating class of macromolecules from both functional and structural perspectives. They catalyze the reactions that sustain life, bind ligands with high affinity and specificity, and mediate interactions among biomolecules in complex ...
Dooling, Lawrence J., Tirrell, David A.
core   +1 more source

In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22

Фармакокинетика и Фармакодинамика, 2017
In the present work, the neuroprotective effect stereospecificity of dimeric dipeptide mimetic of the 4th loop of BDNF-GSB-106 is studied. Activity of its diastereomers GT-106DL (hexamethylenediamide bis-monosuccinyl-D-seryl-L-lysine) and GT-106LD ...
I. O. Logvinov, A. V. Tarasiuk, P. I. Antipov, T. A. Antipova   +3 more
doaj  

Synthesis and Characterization of Mussel Adhesive Peptides [PDF]

, 2005
Mussels, marine organisms, attach to underwater surfaces by making a byssus, which is an extra-corporeal bundle of tiny tendons attached distally to a foreign surface and proximally by insertion of the root into the byssal retractor muscles.
Deshmukh Manjeet Vinayakrao, Geyer, Armin Prof. Dr.   +1 more
core   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Ruthenium-catalyzed azide alkyne cycloaddition reaction: scope, mechanism and applications [PDF]

, 2016
The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1,5-disubstituted 1,2,3-triazoles in one step and complements the more established copper-catalyzed reaction providing the 1,4-isomer.
Akimova G., Akimova G., Akimova G., Anna Said Stålsmeden, Bader R. F. W., Chandrasekaran S., Das R., Fan W.-Q., Fokin V. V., Gruchlik A., Huisgen R., Johan R. Johansson, Keicher T., Levin J. I., Murahashi S.-I., Neumajer G., Nina Kann, Palaniraja J., Parsons J. G., Schilling C., Tamás Beke-Somfai, Trabocchi A., Yubo J., Zhou Y. B.   +23 more
core   +2 more sources