Results 81 to 90 of about 3,651 (206)
Фармакокинетика и Фармакодинамика, 2016 Pharmacological activity of dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4, correspondingly GTS-115 and GK-2, was studied in a model of ischemic stroke, induced by transient middle cerebral artery occlusion in rats.
P. Y. Povarnina +2 more
doaj
PLoS ONE, 2019 Interactive relationships among metabolism, mitochondrial dysfunction and inflammation at skeletal muscle level play a key role in the pathogenesis of disorders related to oxidative stress.
Rita Rezzani +4 more
doaj +1 more source
Functional and structural mimics of superoxide dismutase enzymes [PDF]
, 2008 Superoxide dismutase (SOD) enzymes form important defence line in living organisms. Through a dismutation reaction they transform the highly reactive superoxide radical ion to oxygen and hydrogen peroxide.
Pálinkó, István
core
Structure-activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S [PDF]
, 2011 A new series of organotelluranes were synthesized and investigated, and the structure-activity relationships in cysteine proteases inhibition were determinated.
Alves, Marcio Fernando +5 more
core +1 more source
Stimuli‐responsive hydrogels: An intelligent tool for wound management
Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.For chronic and complex wounds, this review focuses on intelligent hydrogels capable of responding to wound microenvironmental cues (e.g., pH, enzymes) or external stimuli (e.g., light, electricity). These advanced materials enable the dynamic regulation of drug release and real‐time monitoring of healing progression, thereby offering innovative ...
Debin Zheng +10 more
wiley +1 more source
Complex Systems Analysis of Arrested Neural Cell Differentiation during Development and Analogous Cell Cycling Models in Carcinogenesis [PDF]
, 2004 A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell cycling network transformations involved in ...
Baianu, Professor I.C. +1 more
core
A user-friendly Matlab program and GUI for the pseudorotation analysis of saturated five-membered ring systems based on scalar coupling constants [PDF]
, 2008 Background: The advent of combinatorial chemistry has revived the interest in five-membered heterocyclic rings as scaffolds in pharmaceutical research. They are also the target of modifications in nucleic acid chemistry.
Pieter MS Hendrickx, José C Martins
core +3 more sources
Small, Volume 22, Issue 16, 17 March 2026.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Peptide based amphiphiles [PDF]
, 2004 Contains fulltext : 13849.pdf (publisher's version ) (Open ...
Ariga +45 more
core +2 more sources
A Review of Current Computational Tools for Peptide–Protein Docking
Journal of Computational Chemistry, Volume 47, Issue 5, 15 February 2026.In this review, we compare 14 specialized peptide‐protein docking programs, adaptable small‐molecule docking tools, and emerging AI‐driven approaches. By clarifying how each method works, we offer researchers an accessible guide to selecting the most suitable tools for biochemical studies and peptide‐focused drug discovery.
Fábio G. Martins +2 more
wiley +1 more source