Results 91 to 100 of about 3,651 (206)

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Analysis of the haptoglobin binding region on the apolipoprotein A-I-derived P2a peptide [PDF]

, 2013
Apolipoprotein A-I (ApoA-I) is the main protein component of the high density lipoproteins and it plays an important role in the reverse cholesterol transport.
Alayash, Balestrieri, Bradford, Braeckman, Bucci, Chen, Cigliano, Cigliano, Cigliano, Davidson, De Bacquer, DeGrado, Giblett, Gutteridge, Huang, Kristiansen, Langlois, Luo, Matuszek, Mei, Nagel, Porta, Rohl, Salvatore, Sevugan Chetty, Sorci-Thomas, Sorci-Thomas, Spagnuolo, Spagnuolo, Thomas, Vuilleumier, Wu, Wu   +32 more
core   +1 more source

Design and synthesis of amidine-type peptide bond isosteres: application of nitrile oxide derivatives as active ester equivalents in peptide and peptidomimetics synthesis. [PDF]

, 2011
Amidine-type peptide bond isosteres were designed based on the substitution of the peptide bond carbonyl (C=O) group with an imino (C=NH) group. The positively-charged property of the isosteric part resembles a reduced amide-type peptidomimetic.
Fujii, Nobutaka, Hozumi, Kentaro, Inokuchi, Eriko, Nomizu, Motoyoshi, Ohno, Hiroaki, Oishi, Shinya, Tomita, Kenji, Yamada, Ai   +7 more
core   +1 more source

Pharmacokinetics of dimeric dipeptide mimetic of nerve growth factor GK-2 in rats. Part 2. Kinetics of distribution in organs and tissues

Фармакокинетика и Фармакодинамика
Relevance. To introduce the GK-2 compound into clinical practice, it is necessary to conduct a preclinical study of its pharmacokinetics, in particular, the distribution of the studied drug in organs and tissues.
G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, O. Yu. Kravtsova, O. G. Gribakina, P. Yu. Povarnina, V. P. Zherdev   +6 more
doaj   +1 more source

Peptidergic control in a fruit crop pest: The spotted-wing drosophila, Drosophila suzukii [PDF]

, 2017
Neuropeptides play an important role in the regulation of feeding in insects and offer potential targets for the development of new chemicals to control insect pests.
A Duttlinger, A Hariton, A Liscia, AB Lange, AC Chen, AG Cuthbertson, AT Haselton, Caroline S. Gough, CR Peller, D Mazzi, DJ Bruck, EC Johnson, EH Beers, EP Masler, Erik C. Johnson, G Cazzamali, G De Ros, G Gade, Grace M. Fairlamb, J Mccormick, JE Casida, JG Stoffolano, K Egerod, LM Diepenbrock, M Altstein, M Depra, M Mispelon, MK Asplen, MP Bolda, N Audsley, N Audsley, N Audsley, Neil Audsley, Petra Bell, QR Zhang, R Barney, R. Elwyn Isaac, RE Goodhue, RJ Nachman, RJ Nachman, Ronald J. Nachman, S Kaminski, S Richer, S Van Timmeren, T Meeusen, VR Chintapalli, WG Bendena   +46 more
core   +2 more sources

The natriuretic peptides system in the pathophysiology of heart failure. From molecular basis to treatment [PDF]

, 2016
After its discovery in the early 1980s, the natriuretic peptide (NP) system has been extensively characterized and its potential influence in the development and progression of heart failure (HF) has been investigated.
Carnovali, Marino, MASTROMARINO, VITTORIA, VOLPE, Massimo   +2 more
core   +1 more source

Targeted Drug Delivery Across the Blood Brain Barrier in Alzheimer's Disease [PDF]

, 2013
The discovery of drugs for Alzheimer's disease (AD) therapy that can also permeate the blood brain barrier (BBB) is very difficult owing to its specificity and restrictive nature.
Rocha, Sandra
core   +1 more source

Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

Drug Design, Development and Therapy, 2016
Tatyana A Gudasheva,1 Polina Povarnina,1 Ilya O Logvinov,2 Tatyana A Antipova,2 Sergey B Seredenin3 1Department of Medicinal Chemistry, 2Department of Neuroprotective Pharmacology, 3Department of Pharmacogenetics, VV Zakusov Institute of Pharmacology ...
Gudasheva TA, Povarnina P, Logvinov IO, Antipova TA, Seredenin SB   +4 more
doaj  

β-Barrel scaffolds for the grafting of extracellular loops from G-protein-coupled receptors [PDF]

, 2017
Owing to the difficulties in production and purification of G-protein-coupled receptors (GPCRs), relatively little structural information is available about this class of receptors.
Kleinschmidt, Jörg H., Skerra, Arne, Walser, Reto, Zerbe, Oliver   +3 more
core   +1 more source

The protein epitope mimetic approach to protein-protein interaction inhibitors [PDF]

, 2011
Moehle, K, Robinson, J A
core   +1 more source